Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age
In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) and magnetic resonance imaging data. WMH were measured...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/56298 |
| Acceso en línea: | http://hdl.handle.net/10230/56298 http://dx.doi.org/10.3390/biology12010033 |
| Access Level: | acceso abierto |
| Palabra clave: | White matter hyperintensities Cerebral small vessel disease Epigenetics DNA methylation Biological age Epigenetic clock |
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Epigenetic clock explains white matter hyperintensity burden irrespective of chronological ageJiménez-Balado, JoanGiralt-Steinhauer, EvaFernández-Pérez, IsabelRey, LucíaCuadrado-Godia, ElisaOis Santiago, Angel JavierRodríguez-Campello, AnaSoriano Tarraga, CarolinaLazcano, UxueMacias-Gómez, AdriàSuárez-Pérez, AntoniRevert-Barberá, AnnaEstragués-Gázquez, IsabelBeltrán Mármol, Marlyn BriggithMedrano-Martorell, SantiagoCapellades, JaumeRoquer, JaumeJiménez Conde, JordiWhite matter hyperintensitiesCerebral small vessel diseaseEpigeneticsDNA methylationBiological ageEpigenetic clockIn this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) and magnetic resonance imaging data. WMH were measured using a semi-automated method. B-age was calculated using two widely used methods: the Hannum and Horvath formulas. We used multiple linear regression models to interrogate the role of B-age on WMH volume after adjusting for chronological age (C-age) and other covariables. Average C-age of the sample was 68.4 (±11.8) and we observed a relatively high median WMH volume (median = 8.8 cm3, Q1–Q3 = 4.05–18.8). After adjusting for potential confounders, we observed a significant effect of B-ageHannum on WMH volume (βHannum = 0.023, p-value = 0.029) independently of C-age, which remained significant (βC-age = 0.021, p-value = 0.036). Finally, we performed a mediation analysis, which allowed us to discover that 42.7% of the effect of C-age on WMH is mediated by B-ageHannum. On the other hand, B-ageHoarvath showed no significant associations with WMH after being adjusted for C-age. In conclusion, we show for the first time that biological age, measured through DNA methylation, contributes substantially to explain WMH volumetric burden irrespective of chronological age.MDPI202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/56298http://dx.doi.org/10.3390/biology12010033reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBiology. 2023 Jan;12(1):33© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/562982026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age |
| title |
Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age |
| spellingShingle |
Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age Jiménez-Balado, Joan White matter hyperintensities Cerebral small vessel disease Epigenetics DNA methylation Biological age Epigenetic clock |
| title_short |
Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age |
| title_full |
Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age |
| title_fullStr |
Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age |
| title_full_unstemmed |
Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age |
| title_sort |
Epigenetic clock explains white matter hyperintensity burden irrespective of chronological age |
| dc.creator.none.fl_str_mv |
Jiménez-Balado, Joan Giralt-Steinhauer, Eva Fernández-Pérez, Isabel Rey, Lucía Cuadrado-Godia, Elisa Ois Santiago, Angel Javier Rodríguez-Campello, Ana Soriano Tarraga, Carolina Lazcano, Uxue Macias-Gómez, Adrià Suárez-Pérez, Antoni Revert-Barberá, Anna Estragués-Gázquez, Isabel Beltrán Mármol, Marlyn Briggith Medrano-Martorell, Santiago Capellades, Jaume Roquer, Jaume Jiménez Conde, Jordi |
| author |
Jiménez-Balado, Joan |
| author_facet |
Jiménez-Balado, Joan Giralt-Steinhauer, Eva Fernández-Pérez, Isabel Rey, Lucía Cuadrado-Godia, Elisa Ois Santiago, Angel Javier Rodríguez-Campello, Ana Soriano Tarraga, Carolina Lazcano, Uxue Macias-Gómez, Adrià Suárez-Pérez, Antoni Revert-Barberá, Anna Estragués-Gázquez, Isabel Beltrán Mármol, Marlyn Briggith Medrano-Martorell, Santiago Capellades, Jaume Roquer, Jaume Jiménez Conde, Jordi |
| author_role |
author |
| author2 |
Giralt-Steinhauer, Eva Fernández-Pérez, Isabel Rey, Lucía Cuadrado-Godia, Elisa Ois Santiago, Angel Javier Rodríguez-Campello, Ana Soriano Tarraga, Carolina Lazcano, Uxue Macias-Gómez, Adrià Suárez-Pérez, Antoni Revert-Barberá, Anna Estragués-Gázquez, Isabel Beltrán Mármol, Marlyn Briggith Medrano-Martorell, Santiago Capellades, Jaume Roquer, Jaume Jiménez Conde, Jordi |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
White matter hyperintensities Cerebral small vessel disease Epigenetics DNA methylation Biological age Epigenetic clock |
| topic |
White matter hyperintensities Cerebral small vessel disease Epigenetics DNA methylation Biological age Epigenetic clock |
| description |
In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included in this study 247 patients with acute stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) and magnetic resonance imaging data. WMH were measured using a semi-automated method. B-age was calculated using two widely used methods: the Hannum and Horvath formulas. We used multiple linear regression models to interrogate the role of B-age on WMH volume after adjusting for chronological age (C-age) and other covariables. Average C-age of the sample was 68.4 (±11.8) and we observed a relatively high median WMH volume (median = 8.8 cm3, Q1–Q3 = 4.05–18.8). After adjusting for potential confounders, we observed a significant effect of B-ageHannum on WMH volume (βHannum = 0.023, p-value = 0.029) independently of C-age, which remained significant (βC-age = 0.021, p-value = 0.036). Finally, we performed a mediation analysis, which allowed us to discover that 42.7% of the effect of C-age on WMH is mediated by B-ageHannum. On the other hand, B-ageHoarvath showed no significant associations with WMH after being adjusted for C-age. In conclusion, we show for the first time that biological age, measured through DNA methylation, contributes substantially to explain WMH volumetric burden irrespective of chronological age. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/56298 http://dx.doi.org/10.3390/biology12010033 |
| url |
http://hdl.handle.net/10230/56298 http://dx.doi.org/10.3390/biology12010033 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Biology. 2023 Jan;12(1):33 |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
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application/pdf application/pdf |
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MDPI |
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MDPI |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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