Characterization of white matter hyperintensities in Down syndrome

INTRODUCTION: In Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer's disease (AD) biomarkers remain largely unexplored. METHODS: In 261 DS adults and 131 euploid controls, fluid-attenuated...

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Detalles Bibliográficos
Autores: Morcillo-Nieto, AO, Zsadanyi, SE, Arriola-Infante, JE, Carmona-Iragui, M, Montal, V, Pegueroles, J, Aranha, MR, Vaque-Alcazar, L, Padilla, C, Benejam, B, Videla, L, Barroeta, I, Fernandez, S, Altuna, M, Gimenez, S, Gonzalez-Ortiz, S, Bargallo, N, Ribas, L, Arranz, J, Torres, S, Iulita, MF, Belbin, O, Camacho, V, Alcolea, D, Lleo, A, Fortea, J, Bejanin, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p17972
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17972
http://ddd.uab.cat/record/308074
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Down syndrome
magnetic resonance imaging
neuroimaging
small vessel disease
white matter hyperintensities
Descripción
Sumario:INTRODUCTION: In Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer's disease (AD) biomarkers remain largely unexplored. METHODS: In 261 DS adults and 131 euploid controls, fluid-attenuated inversion recovery magnetic resonance imaging scans were segmented and WMHs were extracted in concentric white matter layers and lobar regions. We tested associations with AD clinical stages, sociodemographic data, cerebrospinal fluid (CSF) AD biomarkers, and gray matter (GM) volume. RESULTS: In DS, total WMHs arose at age 43 and showed stronger associations with age than in controls. WMH volume increased along the AD continuum, particularly in periventricular regions, and frontal, parietal, and occipital lobes. Associations were found with CSF biomarkers and temporo-parietal GM volumes. DISCUSSION: WMHs increase 10 years before AD symptom onset in DS and are closely linked with AD biomarkers and neurodegeneration. This suggests a direct connection to AD pathophysiology, independent of vascular risks.

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