Distribution of cholinergic nerve terminals in the aged human brain measured with [18F]FEOBV PET and its correlation with histological data

[Introduction] [18F]fluoroetoxybenzovesamicol ([18F]FEOBV) is a positron emission topography (PET) tracer for the vesicular acetylcholine transporter (VAChT), a protein located predominantly in synaptic vesicles in cholinergic nerve terminals. We aimed to use [18F]FEOBV PET to study the cholinergic...

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Detalles Bibliográficos
Autores: Okkels, Niels, Horsager, Jacob, Labrador, Miguel Ángel, Hansen, Frederik O., Andersen, Katrine B., Just, Mie Kristine, Fedorova, Tatyana D., Skjærbæk, Casper, Munk, Ole L., Hansen, Kim V., Gottrup, Hanne, Hansen, Allan K., Grothe, Michel J., Borghammer, Per
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/337995
Acceso en línea:http://hdl.handle.net/10261/337995
https://api.elsevier.com/content/abstract/scopus_id/85149178525
Access Level:acceso abierto
Palabra clave:mRNA
Brain
Cholinergic Neurons
Healthy Volunteer
PET-CT
VAChT Proteins
Descripción
Sumario:[Introduction] [18F]fluoroetoxybenzovesamicol ([18F]FEOBV) is a positron emission topography (PET) tracer for the vesicular acetylcholine transporter (VAChT), a protein located predominantly in synaptic vesicles in cholinergic nerve terminals. We aimed to use [18F]FEOBV PET to study the cholinergic topography of the healthy human brain.

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