Cerebral topography of vesicular cholinergic transporter changes in neurologically intact adults: A [18F]FEOBV PET study

Acetylcholine plays a major role in brain cognitive and motor functions with regional cholinergic terminal loss common in several neurodegenerative disorders. We describe age-related declines of regional cholinergic neuron terminal density in vivo using the positron emission tomography (PET) ligand...

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Authors: Kanel, P. (Prabesh)|||/items/59390abb-6e2b-4e7b-ad09-59bbca47afa5, van-der-Zee, S. (Sygrid)|||/items/16e9919a-5169-4995-86b4-9473cbf1bb88, Sanchez-Catasus, C.A. (Carlos A.)|||/items/6fff2519-c3ba-4562-b608-13016b862f31, Koeppe, R.A. (Robert A.)|||/items/7297cf1b-df96-4da5-b050-8e77f675bacd, Scott, P.J.H. (Peter J. H.)|||/items/c2ff488f-e2b7-430d-9330-69aab5e953cf, van-Laar, T. (Teus)|||/items/b0cba7db-5ac4-4f2b-ab47-93a9867f9b29, Albin, R.L. (Roger L.)|||/items/d1b3fdf4-15e6-4b06-a786-4a21a0db476e, Bohnen, N. (Nico)|||/items/4e4d731f-c4dd-4181-9635-6acff28bbefc
Format: article
Publication Date:2022
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/113640
Online Access:https://hdl.handle.net/10171/113640
Access Level:Open access
Keyword:Acetylcholine transporter
Aging
Normal persons
VAChT PET
Description
Summary:Acetylcholine plays a major role in brain cognitive and motor functions with regional cholinergic terminal loss common in several neurodegenerative disorders. We describe age-related declines of regional cholinergic neuron terminal density in vivo using the positron emission tomography (PET) ligand [18F](–)5-Fluoroethoxybenzovesamicol ([18F]FEOBV), a vesamicol analogue selectively binding to the vesicular acetylcholine transporter (VAChT). A total of 42 subjects without clinical evidence of neurologic disease (mean 50.55 [range 20–80] years, 24 Male/18 Female) underwent [18F]FEOBV brain PET imaging. We used SPM based voxel-wise statistical analysis to perform whole brain voxel-based parametric analysis (family-wise error corrected, FWE) and to also extract the most significant clusters of regions correlating with aging with gender as nuisance variable. Age-related VAChT binding reductions were found in primary sensorimotor cortex, visual cortex, caudate nucleus, anterior to mid-cingulum, bilateral insula, para-hippocampus, hippocampus, anterior temporal lobes/amygdala, dorsomedial thalamus, metathalamus, and cerebellum (gender and FWE-corrected, P < 0.05). These findings show a specific topographic pattern of regional vulnerability of cholinergic nerve terminals across multiple cholinergic systems accompanying aging.

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