Teclistamab Improves Patient-Reported Symptoms and Health-Related Quality of Life in Relapsed or Refractory Multiple Myeloma

Introduction: Patients with relapsed or refractory multiple myeloma (RRMM) report significantly lower HRQoL compared with patients with newly diagnosed MM and experience further deterioration in HRQoL with each relapse and subsequent treatment. Therefore, consideration of the impact of treatment on...

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Detalles Bibliográficos
Autores: Martin, Thomas G., Moreau, Philippe|||0000-0003-1780-8746, Usmani, Saad Z., Garfall, Alfred, Mateos, M. V.|||0000-0003-2390-1218, San Miguel, Jesús|||0000-0002-9183-4857, Oriol, Albert|||0000-0001-6804-2221, Nooka, Ajay K.|||0000-0003-4165-6869, Rosiñol, Laura|||0000-0002-2534-9239, Chari, Ajai|||0000-0002-0405-7480, Karlin, Lionel, Krishnan, Amrita, Bahlis, Nizar J.|||0000-0001-7353-7034, Popat, Rakesh|||0000-0001-6553-4618, Besemer, Britta, Martínez-López, Joaquín|||0000-0001-7908-0063, Delforge, Michel, Trancucci, Danielle, Pei, Lixia, Kobos, Rachel, Fastenau, John, Gries, Katharine S., Van De Donk, Niels W.C.J.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:289522
Acceso en línea:https://ddd.uab.cat/record/289522
https://dx.doi.org/urn:doi:10.1016/j.clml.2023.11.001
Access Level:acceso abierto
Descripción
Sumario:Introduction: Patients with relapsed or refractory multiple myeloma (RRMM) report significantly lower HRQoL compared with patients with newly diagnosed MM and experience further deterioration in HRQoL with each relapse and subsequent treatment. Therefore, consideration of the impact of treatment on HRQoL in addition to clinical outcomes is vital. Patients and Methods: In the phase I/II MajesTEC-1 (NCT03145181, NCT04557098) study, patients with RRMM who received teclistamab, an off-the-shelf, T-cell redirecting BCMA × CD3 bispecific antibody, had deep and durable responses with manageable safety. HRQoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30-item and the EuroQol 5 Dimension 5 Level descriptive questionnaire. Changes over time from baseline were measured with a repeated measures mixed-effects model. Proportions of patients with clinically meaningful improvement after starting treatment and time to clinically meaningful worsening were assessed. Results: Compliance was maintained throughout the study. Compared with baseline, positive changes were observed for pain, global health status, and emotional functioning with treatment; other assessments were largely unchanged from baseline. Post hoc analysis showed patients with deeper clinical response generally reported improved HRQoL outcomes. Following an initial decline in HRQoL in some scales, the proportion of patients reporting clinically meaningful improvements increased, while the proportion reporting clinically meaningful worsening decreased over time. Clinically meaningful improvements in pain were reported in ≥40% of patients at most assessment time points. Conclusions: These results complement previously reported clinical benefits and support teclistamab as a promising therapeutic option for patients with RRMM.

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