Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study

Background It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic dis...

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Autores: Cordova, Reynalda, Viallon, Vivian, Fontvieille, Emma, Peruchet-Noray, Laia, Jansana-Riera, Anna, Wagner, Karl-Heinz, Kyrø, Cecilie, Tjønneland, Anne, Katzke, Verena Andrea, Bajracharya, Rashmita, Schulze, Matthias B., Masala, Giovanna, Sieri, Sabina, Panico, Salvatore, Ricceri, Fulvio, Tumino, Rosario, Boer, Jolanda M.A., Verschuren, Monique, van der Schouw, Yvonne T., Jakszyn, Paula, Redondo‑Sánchez, Daniel, Amiano, Pilar, Huerta, José María, Guevara, Marcela, Borné, Yan, Sonestedt, Emily, Tsilidis, Konstantinos K., Millett, Christopher J., Heath, Alicia K., Aglago, Elom K, Aune, Dagfnn, Gunter, Marc J., Ferrari, Pietro, Huybrechts, Inge, Freisling, Heinz
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/5231
Acceso en línea:http://hdl.handle.net/20.500.14342/5231
https://doi.org/10.1016/j.lanepe.2023.100771
Access Level:acceso abierto
Palabra clave:Aliments processats
Alimentació
Multimorbiditat
Sistema cardiovascular -- Malalties
Diabetis
Càncer
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spelling Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort studyCordova, ReynaldaViallon, VivianFontvieille, EmmaPeruchet-Noray, LaiaJansana-Riera, AnnaWagner, Karl-HeinzKyrø, CecilieTjønneland, AnneKatzke, Verena AndreaBajracharya, RashmitaSchulze, Matthias B.Masala, GiovannaSieri, SabinaPanico, SalvatoreRicceri, FulvioTumino, RosarioBoer, Jolanda M.A.Verschuren, Moniquevan der Schouw, Yvonne T.Jakszyn, PaulaRedondo‑Sánchez, DanielAmiano, PilarHuerta, José MaríaGuevara, MarcelaBorné, YanSonestedt, EmilyTsilidis, Konstantinos K.Millett, Christopher J.Heath, Alicia K.Aglago, Elom KAune, DagfnnGunter, Marc J.Ferrari, PietroHuybrechts, IngeFreisling, HeinzAliments processatsAlimentacióMultimorbiditatSistema cardiovascular -- MalaltiesDiabetisCàncerBackground It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and type 2 diabetes. Methods This was a prospective cohort study including 266,666 participants (60% women) free of cancer, cardiovascular disease, and type 2 diabetes at recruitment from seven European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Foods and drinks consumed over the previous 12 months were assessed at baseline by food-frequency questionnaires and classified according to their degree of processing using Nova classification. We used multistate modelling based on Cox regression to estimate cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations of total and subgroups of UPFs with the risk of multimorbidity of cancer and cardiometabolic diseases. Findings After a median of 11.2 years of follow-up, 4461 participants (39% women) developed multimorbidity of cancer and cardiometabolic diseases. Higher UPF consumption (per 1 standard deviation increment, ∼260 g/day without alcoholic drinks) was associated with an increased risk of multimorbidity of cancer and cardiometabolic diseases (HR: 1.09, 95% CI: 1.05, 1.12). Among UPF subgroups, associations were most notable for animal-based products (HR: 1.09, 95% CI: 1.05, 1.12), and artificially and sugar-sweetened beverages (HR: 1.09, 95% CI: 1.06, 1.12). Other subgroups such as ultra-processed breads and cereals (HR: 0.97, 95% CI: 0.94, 1.00) or plant-based alternatives (HR: 0.97, 95% CI: 0.91, 1.02) were not associated with risk. Interpretation Our findings suggest that higher consumption of UPFs increases the risk of cancer and cardiometabolic multimorbidity.info:eu-repo/semantics/publishedVersionElsevierUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna2023info:eu-repo/semantics/article13 p.http://hdl.handle.net/20.500.14342/5231https://doi.org/10.1016/j.lanepe.2023.100771reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésThe Lancet Regional Health Europe, 2023, 35: 100771© L'autor/aAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/52312026-05-29T05:05:01Z
dc.title.none.fl_str_mv Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
title Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
spellingShingle Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
Cordova, Reynalda
Aliments processats
Alimentació
Multimorbiditat
Sistema cardiovascular -- Malalties
Diabetis
Càncer
title_short Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
title_full Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
title_fullStr Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
title_full_unstemmed Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
title_sort Consumption of ultra-processed foods and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
dc.creator.none.fl_str_mv Cordova, Reynalda
Viallon, Vivian
Fontvieille, Emma
Peruchet-Noray, Laia
Jansana-Riera, Anna
Wagner, Karl-Heinz
Kyrø, Cecilie
Tjønneland, Anne
Katzke, Verena Andrea
Bajracharya, Rashmita
Schulze, Matthias B.
Masala, Giovanna
Sieri, Sabina
Panico, Salvatore
Ricceri, Fulvio
Tumino, Rosario
Boer, Jolanda M.A.
Verschuren, Monique
van der Schouw, Yvonne T.
Jakszyn, Paula
Redondo‑Sánchez, Daniel
Amiano, Pilar
Huerta, José María
Guevara, Marcela
Borné, Yan
Sonestedt, Emily
Tsilidis, Konstantinos K.
Millett, Christopher J.
Heath, Alicia K.
Aglago, Elom K
Aune, Dagfnn
Gunter, Marc J.
Ferrari, Pietro
Huybrechts, Inge
Freisling, Heinz
author Cordova, Reynalda
author_facet Cordova, Reynalda
Viallon, Vivian
Fontvieille, Emma
Peruchet-Noray, Laia
Jansana-Riera, Anna
Wagner, Karl-Heinz
Kyrø, Cecilie
Tjønneland, Anne
Katzke, Verena Andrea
Bajracharya, Rashmita
Schulze, Matthias B.
Masala, Giovanna
Sieri, Sabina
Panico, Salvatore
Ricceri, Fulvio
Tumino, Rosario
Boer, Jolanda M.A.
Verschuren, Monique
van der Schouw, Yvonne T.
Jakszyn, Paula
Redondo‑Sánchez, Daniel
Amiano, Pilar
Huerta, José María
Guevara, Marcela
Borné, Yan
Sonestedt, Emily
Tsilidis, Konstantinos K.
Millett, Christopher J.
Heath, Alicia K.
Aglago, Elom K
Aune, Dagfnn
Gunter, Marc J.
Ferrari, Pietro
Huybrechts, Inge
Freisling, Heinz
author_role author
author2 Viallon, Vivian
Fontvieille, Emma
Peruchet-Noray, Laia
Jansana-Riera, Anna
Wagner, Karl-Heinz
Kyrø, Cecilie
Tjønneland, Anne
Katzke, Verena Andrea
Bajracharya, Rashmita
Schulze, Matthias B.
Masala, Giovanna
Sieri, Sabina
Panico, Salvatore
Ricceri, Fulvio
Tumino, Rosario
Boer, Jolanda M.A.
Verschuren, Monique
van der Schouw, Yvonne T.
Jakszyn, Paula
Redondo‑Sánchez, Daniel
Amiano, Pilar
Huerta, José María
Guevara, Marcela
Borné, Yan
Sonestedt, Emily
Tsilidis, Konstantinos K.
Millett, Christopher J.
Heath, Alicia K.
Aglago, Elom K
Aune, Dagfnn
Gunter, Marc J.
Ferrari, Pietro
Huybrechts, Inge
Freisling, Heinz
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.subject.none.fl_str_mv Aliments processats
Alimentació
Multimorbiditat
Sistema cardiovascular -- Malalties
Diabetis
Càncer
topic Aliments processats
Alimentació
Multimorbiditat
Sistema cardiovascular -- Malalties
Diabetis
Càncer
description Background It is currently unknown whether ultra-processed foods (UPFs) consumption is associated with a higher incidence of multimorbidity. We examined the relationship of total and subgroup consumption of UPFs with the risk of multimorbidity defined as the co-occurrence of at least two chronic diseases in an individual among first cancer at any site, cardiovascular disease, and type 2 diabetes. Methods This was a prospective cohort study including 266,666 participants (60% women) free of cancer, cardiovascular disease, and type 2 diabetes at recruitment from seven European countries in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Foods and drinks consumed over the previous 12 months were assessed at baseline by food-frequency questionnaires and classified according to their degree of processing using Nova classification. We used multistate modelling based on Cox regression to estimate cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations of total and subgroups of UPFs with the risk of multimorbidity of cancer and cardiometabolic diseases. Findings After a median of 11.2 years of follow-up, 4461 participants (39% women) developed multimorbidity of cancer and cardiometabolic diseases. Higher UPF consumption (per 1 standard deviation increment, ∼260 g/day without alcoholic drinks) was associated with an increased risk of multimorbidity of cancer and cardiometabolic diseases (HR: 1.09, 95% CI: 1.05, 1.12). Among UPF subgroups, associations were most notable for animal-based products (HR: 1.09, 95% CI: 1.05, 1.12), and artificially and sugar-sweetened beverages (HR: 1.09, 95% CI: 1.06, 1.12). Other subgroups such as ultra-processed breads and cereals (HR: 0.97, 95% CI: 0.94, 1.00) or plant-based alternatives (HR: 0.97, 95% CI: 0.91, 1.02) were not associated with risk. Interpretation Our findings suggest that higher consumption of UPFs increases the risk of cancer and cardiometabolic multimorbidity.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/5231
https://doi.org/10.1016/j.lanepe.2023.100771
url http://hdl.handle.net/20.500.14342/5231
https://doi.org/10.1016/j.lanepe.2023.100771
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The Lancet Regional Health Europe, 2023, 35: 100771
dc.rights.none.fl_str_mv © L'autor/a
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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