The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs

The Mangalitza pig breed has suffered strong population reductions due to competition with more productive cosmopolitan breeds. In the current work, we aimed to investigate the effects of this sustained demographic recession on the genomic diversity of Mangalitza pigs. By using the Porcine Single Nu...

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Autores: Bâlteanu, Valentin Adrian, Figueiredo-Cardoso, T., Amills, Marcel, Egerszegi, I., Anton, I., Beja-Pereira, A., Zsolnai, A.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/207248
Acceso en línea:http://hdl.handle.net/10261/207248
Access Level:acceso abierto
Palabra clave:Polymorphisms
Population
Structure
Admixtures
Homozygosity
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spelling The footprint of recent and strong demographic decline in the genomes of Mangalitza pigsBâlteanu, Valentin AdrianFigueiredo-Cardoso, T.Amills, MarcelEgerszegi, I.Anton, I.Beja-Pereira, A.Zsolnai, A.PolymorphismsPopulationStructureAdmixturesHomozygosityThe Mangalitza pig breed has suffered strong population reductions due to competition with more productive cosmopolitan breeds. In the current work, we aimed to investigate the effects of this sustained demographic recession on the genomic diversity of Mangalitza pigs. By using the Porcine Single Nucleotid Polymorphism BeadChip, we have characterized the genome-wide diversity of 350 individuals including 45 Red Mangalitza (number of samples; n=20 from Hungary and n=25 from Romania), 37 Blond Mangalitza, 26 Swallow-belly Mangalitza, 48 Blond Mangalitza × Duroc crossbreds, 5 Bazna swine, 143 pigs from the Hampshire, Duroc, Landrace, Large White and Pietrain breeds and 46 wild boars from Romania (n=18) and Hungary (n=28). Performance of a multidimensional scaling plot showed that Landrace, Large White and Pietrain pigs clustered independently from Mangalitza pigs and Romanian and Hungarian wild boars. The number and total length of ROH (runs of homozygosity), as well as FROH coefficients (proportion of the autosomal genome covered ROH) did not show major differences between Mangalitza pigs and other wild and domestic pig populations. However, Romanian and Hungarian Red Mangalitza pigs displayed an increased frequency of very long ROH (>30 Mb) when compared with other porcine breeds. These results indicate that Red Mangalitza pigs underwent recent and strong inbreeding probably as a consequence of severe reductions in census size.Part of the research presented in this publication was funded by grant AGL2013–48742-C2–1-R awarded by the Spanish Ministry of Economy as well as by projects TKISSE and TGENRE supported by the Hungarian Ministry of Agriculture. The authors also acknowledge the support of the Spanish Ministry of Economy and Competitivity for the Center of Excellence Severo Ochoa 2016-2019 (SEV-2015-0533) grant awarded to the Centre for Research in Agricultural Genomics (CRAG). Tainã Figueiredo Cardoso was funded with a fellowship from the CAPES Foundation-Coordination of Improvement of Higher Education, Ministry of Education of the Federal Government of Brazil. Thanks also to the CERCA Programme of the Generalitat de Catalunya.Peer reviewedCambridge University PressMinisterio de Economía y Competitividad (España)Ministry of Agriculture (Hungary)Ministério da Educação (Brasil)Generalitat de CatalunyaFundaçao Capes (Brasil)Amills, Marcel [0000-0002-8999-0770]Egerszegi, I. [0000-0003-4099-9640]Zsolnai, A. [0000-0002-8382-1503]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/207248reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-48742-C2-1-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2015-0533https://doi.org/10.1017/S1751731119000582Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2072482026-05-22T06:33:51Z
dc.title.none.fl_str_mv The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
title The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
spellingShingle The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
Bâlteanu, Valentin Adrian
Polymorphisms
Population
Structure
Admixtures
Homozygosity
title_short The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
title_full The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
title_fullStr The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
title_full_unstemmed The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
title_sort The footprint of recent and strong demographic decline in the genomes of Mangalitza pigs
dc.creator.none.fl_str_mv Bâlteanu, Valentin Adrian
Figueiredo-Cardoso, T.
Amills, Marcel
Egerszegi, I.
Anton, I.
Beja-Pereira, A.
Zsolnai, A.
author Bâlteanu, Valentin Adrian
author_facet Bâlteanu, Valentin Adrian
Figueiredo-Cardoso, T.
Amills, Marcel
Egerszegi, I.
Anton, I.
Beja-Pereira, A.
Zsolnai, A.
author_role author
author2 Figueiredo-Cardoso, T.
Amills, Marcel
Egerszegi, I.
Anton, I.
Beja-Pereira, A.
Zsolnai, A.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministry of Agriculture (Hungary)
Ministério da Educação (Brasil)
Generalitat de Catalunya
Fundaçao Capes (Brasil)
Amills, Marcel [0000-0002-8999-0770]
Egerszegi, I. [0000-0003-4099-9640]
Zsolnai, A. [0000-0002-8382-1503]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Polymorphisms
Population
Structure
Admixtures
Homozygosity
topic Polymorphisms
Population
Structure
Admixtures
Homozygosity
description The Mangalitza pig breed has suffered strong population reductions due to competition with more productive cosmopolitan breeds. In the current work, we aimed to investigate the effects of this sustained demographic recession on the genomic diversity of Mangalitza pigs. By using the Porcine Single Nucleotid Polymorphism BeadChip, we have characterized the genome-wide diversity of 350 individuals including 45 Red Mangalitza (number of samples; n=20 from Hungary and n=25 from Romania), 37 Blond Mangalitza, 26 Swallow-belly Mangalitza, 48 Blond Mangalitza × Duroc crossbreds, 5 Bazna swine, 143 pigs from the Hampshire, Duroc, Landrace, Large White and Pietrain breeds and 46 wild boars from Romania (n=18) and Hungary (n=28). Performance of a multidimensional scaling plot showed that Landrace, Large White and Pietrain pigs clustered independently from Mangalitza pigs and Romanian and Hungarian wild boars. The number and total length of ROH (runs of homozygosity), as well as FROH coefficients (proportion of the autosomal genome covered ROH) did not show major differences between Mangalitza pigs and other wild and domestic pig populations. However, Romanian and Hungarian Red Mangalitza pigs displayed an increased frequency of very long ROH (>30 Mb) when compared with other porcine breeds. These results indicate that Red Mangalitza pigs underwent recent and strong inbreeding probably as a consequence of severe reductions in census size.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/207248
url http://hdl.handle.net/10261/207248
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2013-48742-C2-1-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2015-0533
https://doi.org/10.1017/S1751731119000582
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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