State of art of cancer pharmacogenomics in Latin American populations

Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads...

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Authors: López-Cortés, Andrés, Guerrero, Santiago, 1957-, Redal, María Ana, Alvarado, Angel Tito, Quiñones, Luis
Format: article
Status:Published version
Publication Date:2017
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/59168
Online Access:http://hdl.handle.net/10230/59168
http://dx.doi.org/10.3390/ijms18060639
Access Level:Open access
Keyword:Cancer
Single nucleotide polymorphism
Precision medicine
Latin America
Pharmacogenetics
Pharmacogenomics
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spelling State of art of cancer pharmacogenomics in Latin American populationsLópez-Cortés, AndrésGuerrero, Santiago, 1957-Redal, María AnaAlvarado, Angel TitoQuiñones, LuisCancerSingle nucleotide polymorphismPrecision medicineLatin AmericaPharmacogeneticsPharmacogenomicsOver the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.MDPI202420242017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/59168http://dx.doi.org/10.3390/ijms18060639reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésInternational Journal of Molecular Sciences. 2017 Jun;18(6):639© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/591682026-06-12T07:21:37Z
dc.title.none.fl_str_mv State of art of cancer pharmacogenomics in Latin American populations
title State of art of cancer pharmacogenomics in Latin American populations
spellingShingle State of art of cancer pharmacogenomics in Latin American populations
López-Cortés, Andrés
Cancer
Single nucleotide polymorphism
Precision medicine
Latin America
Pharmacogenetics
Pharmacogenomics
title_short State of art of cancer pharmacogenomics in Latin American populations
title_full State of art of cancer pharmacogenomics in Latin American populations
title_fullStr State of art of cancer pharmacogenomics in Latin American populations
title_full_unstemmed State of art of cancer pharmacogenomics in Latin American populations
title_sort State of art of cancer pharmacogenomics in Latin American populations
dc.creator.none.fl_str_mv López-Cortés, Andrés
Guerrero, Santiago, 1957-
Redal, María Ana
Alvarado, Angel Tito
Quiñones, Luis
author López-Cortés, Andrés
author_facet López-Cortés, Andrés
Guerrero, Santiago, 1957-
Redal, María Ana
Alvarado, Angel Tito
Quiñones, Luis
author_role author
author2 Guerrero, Santiago, 1957-
Redal, María Ana
Alvarado, Angel Tito
Quiñones, Luis
author2_role author
author
author
author
dc.subject.none.fl_str_mv Cancer
Single nucleotide polymorphism
Precision medicine
Latin America
Pharmacogenetics
Pharmacogenomics
topic Cancer
Single nucleotide polymorphism
Precision medicine
Latin America
Pharmacogenetics
Pharmacogenomics
description Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.
publishDate 2017
dc.date.none.fl_str_mv 2017
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/59168
http://dx.doi.org/10.3390/ijms18060639
url http://hdl.handle.net/10230/59168
http://dx.doi.org/10.3390/ijms18060639
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences. 2017 Jun;18(6):639
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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