[Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the deve...

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Autores: Ricarte, Marina, Tagkalidou, Niki, Bellot, Marina, Bedrossiantz, Juliette, Prats, Eva, Gomez-Canela, Cristian, Garcia-Reyero, Natalia, Raldúa, Demetrio
Tipo de recurso: conjunto de datos
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/385395
Acceso en línea:http://hdl.handle.net/10261/385395
https://digital.csic.es/handle/10261/365134
Access Level:acceso abierto
Palabra clave:Zebrafish
Animal model
Autism spectrum disorder
Neurotransmitter
Social behavior
Valproic acid
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/6
Ensure healthy lives and promote well-being for all at all ages
Ensure availability and sustainable management of water and sanitation for all
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network_name_str España
repository_id_str
spelling [Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in ZebrafishRicarte, MarinaTagkalidou, NikiBellot, MarinaBedrossiantz, JuliettePrats, EvaGomez-Canela, CristianGarcia-Reyero, NataliaRaldúa, DemetrioZebrafishAnimal modelAutism spectrum disorderNeurotransmitterSocial behaviorValproic acidhttp://metadata.un.org/sdg/3http://metadata.un.org/sdg/6Ensure healthy lives and promote well-being for all at all agesEnsure availability and sustainable management of water and sanitation for allAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the development of ASD. Animal models can serve as crucial tools for understanding the complexity of ASD. In this study, a chemical model of ASD has been developed in zebrafish by exposing embryos to valproic acid (VPA) from 4 to 48 h post-fertilization, rearing them to the adult stage in fish water. For the first time, an integrative approach combining behavioral analysis and neurotransmitters profile has been used for determining the effects of early-life exposure to VPA both in the larval and adult stages. Larvae from VPA-treated embryos showed hyperactivity and decreased visual and vibrational escape responses, as well as an altered neurotransmitters profile, with increased glutamate and decreased acetylcholine and norepinephrine levels. Adults from VPA-treated embryos exhibited impaired social behavior characterized by larger shoal sizes and a decreased interest for their conspecifics. A neurotransmitter analysis revealed a significant decrease in dopamine and GABA levels in the brain. These results support the potential predictive validity of this model for ASD research.Peer reviewedMultidisciplinary Digital Publishing Institute0009-0006-5915-79790000-0001-7838-20270000-0002-9073-63070000-0002-1667-52940000-0001-5256-1641Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1http://hdl.handle.net/10261/385395https://digital.csic.es/handle/10261/365134reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésInternational journal of molecular sciencesShort- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in ZebrafishSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3853952026-05-22T06:33:51Z
dc.title.none.fl_str_mv [Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title [Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
spellingShingle [Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
Ricarte, Marina
Zebrafish
Animal model
Autism spectrum disorder
Neurotransmitter
Social behavior
Valproic acid
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/6
Ensure healthy lives and promote well-being for all at all ages
Ensure availability and sustainable management of water and sanitation for all
title_short [Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_full [Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_fullStr [Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_full_unstemmed [Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_sort [Dataset] Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
dc.creator.none.fl_str_mv Ricarte, Marina
Tagkalidou, Niki
Bellot, Marina
Bedrossiantz, Juliette
Prats, Eva
Gomez-Canela, Cristian
Garcia-Reyero, Natalia
Raldúa, Demetrio
author Ricarte, Marina
author_facet Ricarte, Marina
Tagkalidou, Niki
Bellot, Marina
Bedrossiantz, Juliette
Prats, Eva
Gomez-Canela, Cristian
Garcia-Reyero, Natalia
Raldúa, Demetrio
author_role author
author2 Tagkalidou, Niki
Bellot, Marina
Bedrossiantz, Juliette
Prats, Eva
Gomez-Canela, Cristian
Garcia-Reyero, Natalia
Raldúa, Demetrio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv 0009-0006-5915-7979
0000-0001-7838-2027
0000-0002-9073-6307
0000-0002-1667-5294
0000-0001-5256-1641
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Zebrafish
Animal model
Autism spectrum disorder
Neurotransmitter
Social behavior
Valproic acid
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/6
Ensure healthy lives and promote well-being for all at all ages
Ensure availability and sustainable management of water and sanitation for all
topic Zebrafish
Animal model
Autism spectrum disorder
Neurotransmitter
Social behavior
Valproic acid
http://metadata.un.org/sdg/3
http://metadata.un.org/sdg/6
Ensure healthy lives and promote well-being for all at all ages
Ensure availability and sustainable management of water and sanitation for all
description Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the development of ASD. Animal models can serve as crucial tools for understanding the complexity of ASD. In this study, a chemical model of ASD has been developed in zebrafish by exposing embryos to valproic acid (VPA) from 4 to 48 h post-fertilization, rearing them to the adult stage in fish water. For the first time, an integrative approach combining behavioral analysis and neurotransmitters profile has been used for determining the effects of early-life exposure to VPA both in the larval and adult stages. Larvae from VPA-treated embryos showed hyperactivity and decreased visual and vibrational escape responses, as well as an altered neurotransmitters profile, with increased glutamate and decreased acetylcholine and norepinephrine levels. Adults from VPA-treated embryos exhibited impaired social behavior characterized by larger shoal sizes and a decreased interest for their conspecifics. A neurotransmitter analysis revealed a significant decrease in dopamine and GABA levels in the brain. These results support the potential predictive validity of this model for ASD research.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/385395
https://digital.csic.es/handle/10261/365134
url http://hdl.handle.net/10261/385395
https://digital.csic.es/handle/10261/365134
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International journal of molecular sciences
Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869412299017551872
score 15,812429

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