Maintaining kidney health in aging societies

Ortiz, Alberto|||0000-0002-9805-9523; Kramer, A.|||0000-0002-7560-2669; Rychlík, Ivan|||0000-0002-4245-5949; Nangaku, Masaomi|||0000-0001-7401-2934; Yanagita, Motoko|||0000-0002-0339-9008; Jager, Kitty|||0000-0003-0444-8569; Caskey, Fergus; Stel, Vianda S.; Kuragano, Takahiro|||0000-0001-6453-3824; Yokoi, Hideki|||0000-0001-8343-9737; Fliser, Danilo; Torra Balcells, Roser|||0000-0001-8714-2332; Wanner, Christoph|||0000-0001-9507-5301; Kashihara, Naoki; Suzuki, Yusuke; Takemoto, Yoshiaki; Palladino, Giuseppe

Maintaining kidney health in aging societies

Chronic kidney disease (CKD) is the fastest growing cause of death, expected to become the fifth global cause of death and the third in some countries with long life expectancy, such as Japan and Spain, by 2050. This reflects societal aging, as advancing kidney age is the main risk factor for CKD. T...

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Autores:	Ortiz, Alberto\|\|\|0000-0002-9805-9523, Kramer, A.\|\|\|0000-0002-7560-2669, Rychlík, Ivan\|\|\|0000-0002-4245-5949, Nangaku, Masaomi\|\|\|0000-0001-7401-2934, Yanagita, Motoko\|\|\|0000-0002-0339-9008, Jager, Kitty\|\|\|0000-0003-0444-8569, Caskey, Fergus, Stel, Vianda S., Kuragano, Takahiro\|\|\|0000-0001-6453-3824, Yokoi, Hideki\|\|\|0000-0001-8343-9737, Fliser, Danilo, Torra Balcells, Roser\|\|\|0000-0001-8714-2332, Wanner, Christoph\|\|\|0000-0001-9507-5301, Kashihara, Naoki, Suzuki, Yusuke, Takemoto, Yoshiaki, Palladino, Giuseppe
Formato:	artículo
Fecha de publicación:	2025
País:	España
Recursos:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:dnet:uabarcelona_::f59d5ff71fc9fd0bdac2ee1ec6e0ec50
Acesso em linha:	https://ddd.uab.cat/record/328504 https://dx.doi.org/urn:doi:10.1093/ndt/gfaf068
Access Level:	acceso abierto
Palavra-chave:	Aging Chronic kidney disease Gerosuppression Kidney aging Kidney replacement therapy

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spelling	Maintaining kidney health in aging societiesa JSN and ERA call to actionOrtiz, Alberto\|\|\|0000-0002-9805-9523Kramer, A.\|\|\|0000-0002-7560-2669Rychlík, Ivan\|\|\|0000-0002-4245-5949Nangaku, Masaomi\|\|\|0000-0001-7401-2934Yanagita, Motoko\|\|\|0000-0002-0339-9008Jager, Kitty\|\|\|0000-0003-0444-8569Caskey, FergusStel, Vianda S.Kuragano, Takahiro\|\|\|0000-0001-6453-3824Yokoi, Hideki\|\|\|0000-0001-8343-9737Fliser, DaniloTorra Balcells, Roser\|\|\|0000-0001-8714-2332Wanner, Christoph\|\|\|0000-0001-9507-5301Kashihara, NaokiSuzuki, YusukeTakemoto, YoshiakiPalladino, GiuseppeAgingChronic kidney diseaseGerosuppressionKidney agingKidney replacement therapyChronic kidney disease (CKD) is the fastest growing cause of death, expected to become the fifth global cause of death and the third in some countries with long life expectancy, such as Japan and Spain, by 2050. This reflects societal aging, as advancing kidney age is the main risk factor for CKD. The forecasted 140% increase in the death rate from CKD by 2050 is reduced to 33% when adjusted for age. The increasing mortality burden is paralleled by higher personal, healthcare, socio-economic and environmental burdens and the need for kidney replacement therapy to treat kidney failure. To some extent, the higher CKD burden represents the price of success in prolonging longevity by decreasing other causes of death. Now is the time to act to minimize the negative impact of CKD on aging societies through primary prevention and early diagnosis and treatment of CKD. Action aimed at maintaining kidney health and delaying biological kidney aging will contribute to healthy aging, as the kidneys have gerosuppressor functions and CKD has the highest negative impact on body aging among chronic non-communicable diseases. This action should be part of a move towards novel holistic approaches to healthy longevity represented by concepts such as cardiovascular-kidney-metabolic health, geromedicine, gerosuppressors and organ rejuvenation. We discuss a conceptual framework for the present and future of kidney aging and kidney health in the elderly, emphasizing opportunities for intervention that underlie the Japanese Society of Nephrology and European Renal Association call to action on Achieving Kidney Health in Aging/Aged Societies.Universitat Autònoma de Barcelona. Departament de Medicina 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/328504https://dx.doi.org/urn:doi:10.1093/ndt/gfaf068reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00469Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00050Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00251Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 AC22/00027open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:dnet:uabarcelona_::f59d5ff71fc9fd0bdac2ee1ec6e0ec502026-06-06T12:50:31Z
dc.title.none.fl_str_mv	Maintaining kidney health in aging societies a JSN and ERA call to action
title	Maintaining kidney health in aging societies
spellingShingle	Maintaining kidney health in aging societies Ortiz, Alberto\|\|\|0000-0002-9805-9523 Aging Chronic kidney disease Gerosuppression Kidney aging Kidney replacement therapy
title_short	Maintaining kidney health in aging societies
title_full	Maintaining kidney health in aging societies
title_fullStr	Maintaining kidney health in aging societies
title_full_unstemmed	Maintaining kidney health in aging societies
title_sort	Maintaining kidney health in aging societies
dc.creator.none.fl_str_mv	Ortiz, Alberto\|\|\|0000-0002-9805-9523 Kramer, A.\|\|\|0000-0002-7560-2669 Rychlík, Ivan\|\|\|0000-0002-4245-5949 Nangaku, Masaomi\|\|\|0000-0001-7401-2934 Yanagita, Motoko\|\|\|0000-0002-0339-9008 Jager, Kitty\|\|\|0000-0003-0444-8569 Caskey, Fergus Stel, Vianda S. Kuragano, Takahiro\|\|\|0000-0001-6453-3824 Yokoi, Hideki\|\|\|0000-0001-8343-9737 Fliser, Danilo Torra Balcells, Roser\|\|\|0000-0001-8714-2332 Wanner, Christoph\|\|\|0000-0001-9507-5301 Kashihara, Naoki Suzuki, Yusuke Takemoto, Yoshiaki Palladino, Giuseppe
author	Ortiz, Alberto\|\|\|0000-0002-9805-9523
author_facet	Ortiz, Alberto\|\|\|0000-0002-9805-9523 Kramer, A.\|\|\|0000-0002-7560-2669 Rychlík, Ivan\|\|\|0000-0002-4245-5949 Nangaku, Masaomi\|\|\|0000-0001-7401-2934 Yanagita, Motoko\|\|\|0000-0002-0339-9008 Jager, Kitty\|\|\|0000-0003-0444-8569 Caskey, Fergus Stel, Vianda S. Kuragano, Takahiro\|\|\|0000-0001-6453-3824 Yokoi, Hideki\|\|\|0000-0001-8343-9737 Fliser, Danilo Torra Balcells, Roser\|\|\|0000-0001-8714-2332 Wanner, Christoph\|\|\|0000-0001-9507-5301 Kashihara, Naoki Suzuki, Yusuke Takemoto, Yoshiaki Palladino, Giuseppe
author_role	author
author2	Kramer, A.\|\|\|0000-0002-7560-2669 Rychlík, Ivan\|\|\|0000-0002-4245-5949 Nangaku, Masaomi\|\|\|0000-0001-7401-2934 Yanagita, Motoko\|\|\|0000-0002-0339-9008 Jager, Kitty\|\|\|0000-0003-0444-8569 Caskey, Fergus Stel, Vianda S. Kuragano, Takahiro\|\|\|0000-0001-6453-3824 Yokoi, Hideki\|\|\|0000-0001-8343-9737 Fliser, Danilo Torra Balcells, Roser\|\|\|0000-0001-8714-2332 Wanner, Christoph\|\|\|0000-0001-9507-5301 Kashihara, Naoki Suzuki, Yusuke Takemoto, Yoshiaki Palladino, Giuseppe
author2_role	author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Universitat Autònoma de Barcelona. Departament de Medicina
dc.subject.none.fl_str_mv	Aging Chronic kidney disease Gerosuppression Kidney aging Kidney replacement therapy
topic	Aging Chronic kidney disease Gerosuppression Kidney aging Kidney replacement therapy
description	Chronic kidney disease (CKD) is the fastest growing cause of death, expected to become the fifth global cause of death and the third in some countries with long life expectancy, such as Japan and Spain, by 2050. This reflects societal aging, as advancing kidney age is the main risk factor for CKD. The forecasted 140% increase in the death rate from CKD by 2050 is reduced to 33% when adjusted for age. The increasing mortality burden is paralleled by higher personal, healthcare, socio-economic and environmental burdens and the need for kidney replacement therapy to treat kidney failure. To some extent, the higher CKD burden represents the price of success in prolonging longevity by decreasing other causes of death. Now is the time to act to minimize the negative impact of CKD on aging societies through primary prevention and early diagnosis and treatment of CKD. Action aimed at maintaining kidney health and delaying biological kidney aging will contribute to healthy aging, as the kidneys have gerosuppressor functions and CKD has the highest negative impact on body aging among chronic non-communicable diseases. This action should be part of a move towards novel holistic approaches to healthy longevity represented by concepts such as cardiovascular-kidney-metabolic health, geromedicine, gerosuppressors and organ rejuvenation. We discuss a conceptual framework for the present and future of kidney aging and kidney health in the elderly, emphasizing opportunities for intervention that underlie the Japanese Society of Nephrology and European Renal Association call to action on Achieving Kidney Health in Aging/Aged Societies.
publishDate	2025
dc.date.none.fl_str_mv	2 2025-01-01 2025 2025-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/328504 https://dx.doi.org/urn:doi:10.1093/ndt/gfaf068
url	https://ddd.uab.cat/record/328504 https://dx.doi.org/urn:doi:10.1093/ndt/gfaf068
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00469 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/00050 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00251 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 AC22/00027
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
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Maintaining kidney health in aging societies

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