Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effects

This article belongs to the Special Issue Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition.

Bibliographic Details
Authors: Quero, Javier, Paesa, Mónica, Morales, Carmen, Mendoza, Gracia, Osada, Jesús, Teixeira, José António, Ferreira-Santos, Pedro, Rodríguez-Yoldi, María Jesús
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/380633
Online Access:http://hdl.handle.net/10261/380633
Access Level:Open access
Keyword:Boletus edulis
Anti-cancer
Caco-2 cells
Anti-inflammatory
Antioxidant
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spelling Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effectsQuero, JavierPaesa, MónicaMorales, CarmenMendoza, GraciaOsada, JesúsTeixeira, José AntónioFerreira-Santos, PedroRodríguez-Yoldi, María Jesús Boletus edulisAnti-cancerCaco-2 cellsAnti-inflammatoryAntioxidantThis article belongs to the Special Issue Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition.Boletus edulis (BE) is a mushroom well known for its taste, nutritional value, and medicinal properties. The objective of this work was to study the biological effects of BE extracts on human colon carcinoma cells (Caco-2), evaluating parameters related to oxidative stress and inflammation. In this study, a hydroethanolic extract of BE was obtained by ohmic heating green technology. The obtained BE extracts are mainly composed of sugars (mainly trehalose), phenolic compounds (taxifolin, rutin, and ellagic acid), and minerals (K, P, Mg, Na, Ca, Zn, Se, etc.). The results showed that BE extracts were able to reduce cancer cell proliferation by the induction of cell cycle arrest at the G0/G1 stage, as well as cell death by autophagy and apoptosis, the alteration of mitochondrial membrane potential, and caspase-3 activation. The extracts modified the redox balance of the cell by increasing the ROS levels associated with a decrease in the thioredoxin reductase activity. Similarly, BE extracts attenuated Caco-2 inflammation by reducing both iNOS and COX-2 mRNA expression and COX-2 protein expression. In addition, BE extracts protected the intestine from the oxidative stress induced by H2O2. Therefore, this study provides information on the potential use of BE bioactive compounds as anticancer therapeutic agents and as functional ingredients to prevent oxidative stress in the intestinal barrier.The authors would like to acknowledge the Ministerio de Ciencia e Innovación-Fondo Europeo de Desarrollo Regional (PID2022-136414OB-I00), Fondo Social Europeo-Gobierno de Aragón (B16_23R), Fondo Social Europeo de Desarrollo Rural-Gobierno de Aragón a través de un Contrato de Asistencia Técnica y Desarroll0 Experimental entre la Universidad de Zaragoza y Gardeniers S.L.U. (GCP2021002300), Interreg Sudoe Program (NEWPOWER, S1/1.1/E01116), and CIBER Fisiopatología de la Obesidad y la Nutrición as an initiative of FEDER-ICCIII (CIBEROBN, CB06/03/1012) for their financial support. Javier Quero was the recipient of a contract from the Universidad de Zaragoza within the Investigo Program subsidized by the European Union (Plan Nacional de Recuperación, Transformación y Resiliencia). P. Ferreira-Santos is grateful to the Spanish Ministry of Science, Innovation and Universities, and the European Union—NextGenerationEU/PRTR—for their postdoctoral grant (FJC2021-046978-I). G.M. gratefully acknowledges the support from the Miguel Servet Program (MS19/00092; ISCIII).Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionGobierno de AragónInstituto de Salud Carlos IIIUniversidad de ZaragozaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/380633reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136414OB-I00info:eu-repo/grantAgreement/AEI//FJC2021-046978-IThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/antiox13080908/s1https://doi.org/10.3390/antiox13080908Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3806332026-05-22T06:33:51Z
dc.title.none.fl_str_mv Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effects
title Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effects
spellingShingle Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effects
Quero, Javier
Boletus edulis
Anti-cancer
Caco-2 cells
Anti-inflammatory
Antioxidant
title_short Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effects
title_full Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effects
title_fullStr Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effects
title_full_unstemmed Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effects
title_sort Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-Inflammatory effects
dc.creator.none.fl_str_mv Quero, Javier
Paesa, Mónica
Morales, Carmen
Mendoza, Gracia
Osada, Jesús
Teixeira, José António
Ferreira-Santos, Pedro
Rodríguez-Yoldi, María Jesús
author Quero, Javier
author_facet Quero, Javier
Paesa, Mónica
Morales, Carmen
Mendoza, Gracia
Osada, Jesús
Teixeira, José António
Ferreira-Santos, Pedro
Rodríguez-Yoldi, María Jesús
author_role author
author2 Paesa, Mónica
Morales, Carmen
Mendoza, Gracia
Osada, Jesús
Teixeira, José António
Ferreira-Santos, Pedro
Rodríguez-Yoldi, María Jesús
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Gobierno de Aragón
Instituto de Salud Carlos III
Universidad de Zaragoza
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Boletus edulis
Anti-cancer
Caco-2 cells
Anti-inflammatory
Antioxidant
topic Boletus edulis
Anti-cancer
Caco-2 cells
Anti-inflammatory
Antioxidant
description This article belongs to the Special Issue Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose—2nd Edition.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/380633
url http://hdl.handle.net/10261/380633
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136414OB-I00
info:eu-repo/grantAgreement/AEI//FJC2021-046978-I
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.3390/antiox13080908/s1
https://doi.org/10.3390/antiox13080908
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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