Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires

[Background] Tradiditional physicochemical approaches for the synthesis of compounds, drugs, and nanostructures developed as potential solutions for antimicrobial resistance or against cancer treatment are, for the most part, facile and straightforward. Nevertheless, these approaches have several li...

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Autores: Vernet Crua, Ada, Medina Cruz, David, Zhang, Bohan, González Sagardoy, María Ujué, Huttel, Yves, García-Martín, José Miguel, Cholula-Díaz, Jorge L., Webster, Thomas J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/187028
Acceso en línea:http://hdl.handle.net/10261/187028
Access Level:acceso abierto
Palabra clave:Nanowires
Tellurium
Biocompatibility
Anticancer
Green chemistry
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spelling Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowiresVernet Crua, AdaMedina Cruz, DavidZhang, BohanGonzález Sagardoy, María UjuéHuttel, YvesGarcía-Martín, José MiguelCholula-Díaz, Jorge L.Webster, Thomas J.NanowiresTelluriumBiocompatibilityAnticancerGreen chemistry[Background] Tradiditional physicochemical approaches for the synthesis of compounds, drugs, and nanostructures developed as potential solutions for antimicrobial resistance or against cancer treatment are, for the most part, facile and straightforward. Nevertheless, these approaches have several limitations, such as the use of toxic chemicals and production of toxic by-products with limited biocompatibility. Therefore, new methods are needed to address these limitations, and green chemistry offers a suitable and novel answer, with the safe and environmentally friendly design, manufacturing, and use of minimally toxic chemicals. Green chemistry approaches are especially useful for the generation of metallic nanoparticles or nanometric structures that can effectively and efficiently address health care concerns.[Objective] Here, tellurium (Te) nanowires were synthesized using a novel green chemistry approach, and their structures and cytocompatibility were evaluated.[Method] An easy and straightforward hydrothermal method was employed, and the Te nanowires were characterized using transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, X-ray powder diffraction, X-ray photoelectron spectroscopy, and optical microscopy for morphology, size, and chemistry. Cytotoxicity tests were performed with human dermal fibroblasts and human melanoma cells (to assess anticancer properties). The results showed that a treatment with Te nanowires at concentrations between 5 and 100 µg/mL improved the proliferation of healthy cells and decreased cancerous cell growth over a 5-day period. Most importantly, the green chemistry -synthesized Te nanowires outperformed those produced by traditional synthetic chemical methods.[Conclusion] This study suggests that green chemistry approaches for producing Te nanostructures may not only reduce adverse environmental effects resulting from traditional synthetic chemistry methods, but also be more effective in numerous health care applications.Dr María Ujué González reports grants from MINECO, MINECO + EU, and the Government of Autonomous Region of Madrid, CM, during the conduct of the study. Dr Yves Huttel reports grants from MINECO during the conduct of the study. Dr José Miguel García-Martín reports grants from MINECO, MECD, and Fulbright Commission, during the conduct of the study.Peer reviewedDove PressMinisterio de Economía y Competitividad (España)European CommissionComunidad de MadridMinisterio de Educación, Cultura y Deporte (España)Fulbright CommissionMedina Cruz, David [0000-0002-7658-583X]Zhang, Bohan [0000-0002-0066-2755]González Sagardoy, María Ujué [0000-0001-7012-0049]Huttel, Yves [0000-0002-3683-9890]García-Martín, José Miguel [0000-0002-5908-8428]Cholula-Díaz, Jorge L. [0000-0002-4457-1572]Webster, Thomas J. [0000-0002-2028-5969]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/187028reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.2147/IJN.S175640Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1870282026-05-22T06:33:51Z
dc.title.none.fl_str_mv Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
spellingShingle Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
Vernet Crua, Ada
Nanowires
Tellurium
Biocompatibility
Anticancer
Green chemistry
title_short Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title_full Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title_fullStr Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title_full_unstemmed Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
title_sort Comparison of cytocompatibility and anticancer properties of traditional and green chemistry-synthesized tellurium nanowires
dc.creator.none.fl_str_mv Vernet Crua, Ada
Medina Cruz, David
Zhang, Bohan
González Sagardoy, María Ujué
Huttel, Yves
García-Martín, José Miguel
Cholula-Díaz, Jorge L.
Webster, Thomas J.
author Vernet Crua, Ada
author_facet Vernet Crua, Ada
Medina Cruz, David
Zhang, Bohan
González Sagardoy, María Ujué
Huttel, Yves
García-Martín, José Miguel
Cholula-Díaz, Jorge L.
Webster, Thomas J.
author_role author
author2 Medina Cruz, David
Zhang, Bohan
González Sagardoy, María Ujué
Huttel, Yves
García-Martín, José Miguel
Cholula-Díaz, Jorge L.
Webster, Thomas J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Comunidad de Madrid
Ministerio de Educación, Cultura y Deporte (España)
Fulbright Commission
Medina Cruz, David [0000-0002-7658-583X]
Zhang, Bohan [0000-0002-0066-2755]
González Sagardoy, María Ujué [0000-0001-7012-0049]
Huttel, Yves [0000-0002-3683-9890]
García-Martín, José Miguel [0000-0002-5908-8428]
Cholula-Díaz, Jorge L. [0000-0002-4457-1572]
Webster, Thomas J. [0000-0002-2028-5969]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Nanowires
Tellurium
Biocompatibility
Anticancer
Green chemistry
topic Nanowires
Tellurium
Biocompatibility
Anticancer
Green chemistry
description [Background] Tradiditional physicochemical approaches for the synthesis of compounds, drugs, and nanostructures developed as potential solutions for antimicrobial resistance or against cancer treatment are, for the most part, facile and straightforward. Nevertheless, these approaches have several limitations, such as the use of toxic chemicals and production of toxic by-products with limited biocompatibility. Therefore, new methods are needed to address these limitations, and green chemistry offers a suitable and novel answer, with the safe and environmentally friendly design, manufacturing, and use of minimally toxic chemicals. Green chemistry approaches are especially useful for the generation of metallic nanoparticles or nanometric structures that can effectively and efficiently address health care concerns.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/187028
url http://hdl.handle.net/10261/187028
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.2147/IJN.S175640
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Dove Press
publisher.none.fl_str_mv Dove Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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