Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression

Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differenc...

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Autores: Argyelan, Miklos|||0000-0002-7254-1776, Deng, Zhi-De|||0000-0001-8925-0871, Ousdal, Olga Therese|||0000-0002-0728-3141, Oltedal, Leif|||0000-0003-3316-7950, Angulo, Brian, Baradits, Mate, Spitzberg, Andrew J.|||0000-0001-9379-2075, Kessler, Ute, Sartorius, Alexander|||0000-0002-1243-3693, Dols, Annemiek, Narr, Katherine L.|||0000-0002-9396-7936, Espinoza, Randall|||0000-0003-2895-4212, van Waarde, Jeroen A.|||0000-0001-6792-5727, Tendolkar, Indira|||0000-0003-3171-3671, van Eijndhoven, Philip, van Wingen, Guido|||0000-0003-3076-5891, Takamiya, Akihiro|||0000-0003-2985-6673, Kishimoto, Taishiro, Jorgensen, Martin Balslev|||0000-0002-1321-8901, Jorgensen, Anders, Paulson, Olaf B.|||0000-0001-7712-8596, Yrondi, Antoine|||0000-0002-2650-6080, Péran, Patrice, Soriano-Mas, Carles|||0000-0003-4574-6597, Cardoner, Narcís|||0000-0001-9633-0888, Cano, Marta|||0000-0003-0675-9483, van Diermen, Linda|||0000-0002-3178-4974, Schrijvers, Didier, Belge, Jean-Baptiste, Emsell, Louise|||0000-0003-0011-4158, Bouckaert, Filip, Vandenbulcke, Mathieu, Kiebs, Maximilian|||0000-0002-4216-2679, Hurlemann, René|||0000-0003-2628-565X, Mulders, Peter CR.|||0000-0002-7867-5513, Redlich, Ronny, Dannlowski, Udo|||0000-0002-0623-3759, Kavakbasi, Erhan, Kritzer, Michael D., Ellard, Kristen K., Camprodon, Joan Albert|||0000-0003-1282-9257, Petrides, Georgios, Malhotra, Anil K., Abbott, Christopher|||0000-0001-6884-2464
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:293135
Acesso em linha:https://ddd.uab.cat/record/293135
https://dx.doi.org/urn:doi:10.1038/s41380-023-02318-2
Access Level:acceso abierto
Palavra-chave:Depression
Predictive markers
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spelling Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depressionArgyelan, Miklos|||0000-0002-7254-1776Deng, Zhi-De|||0000-0001-8925-0871Ousdal, Olga Therese|||0000-0002-0728-3141Oltedal, Leif|||0000-0003-3316-7950Angulo, BrianBaradits, MateSpitzberg, Andrew J.|||0000-0001-9379-2075Kessler, UteSartorius, Alexander|||0000-0002-1243-3693Dols, AnnemiekNarr, Katherine L.|||0000-0002-9396-7936Espinoza, Randall|||0000-0003-2895-4212van Waarde, Jeroen A.|||0000-0001-6792-5727Tendolkar, Indira|||0000-0003-3171-3671van Eijndhoven, Philipvan Wingen, Guido|||0000-0003-3076-5891Takamiya, Akihiro|||0000-0003-2985-6673Kishimoto, TaishiroJorgensen, Martin Balslev|||0000-0002-1321-8901Jorgensen, AndersPaulson, Olaf B.|||0000-0001-7712-8596Yrondi, Antoine|||0000-0002-2650-6080Péran, PatriceSoriano-Mas, Carles|||0000-0003-4574-6597Cardoner, Narcís|||0000-0001-9633-0888Cano, Marta|||0000-0003-0675-9483van Diermen, Linda|||0000-0002-3178-4974Schrijvers, DidierBelge, Jean-BaptisteEmsell, Louise|||0000-0003-0011-4158Bouckaert, FilipVandenbulcke, MathieuKiebs, Maximilian|||0000-0002-4216-2679Hurlemann, René|||0000-0003-2628-565XMulders, Peter CR.|||0000-0002-7867-5513Redlich, RonnyDannlowski, Udo|||0000-0002-0623-3759Kavakbasi, ErhanKritzer, Michael D.Ellard, Kristen K.Camprodon, Joan Albert|||0000-0003-1282-9257Petrides, GeorgiosMalhotra, Anil K.Abbott, Christopher|||0000-0001-6884-2464DepressionPredictive markersNeurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this causal depression network (CDN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis Principal Component Analysis (PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CDN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CDN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes (t = -2.35, p = 0.019). This evidence further supports that treatment interventions converge on a CDN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/293135https://dx.doi.org/urn:doi:10.1038/s41380-023-02318-2reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2931352026-06-06T12:50:31Z
dc.title.none.fl_str_mv Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
title Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
spellingShingle Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
Argyelan, Miklos|||0000-0002-7254-1776
Depression
Predictive markers
title_short Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
title_full Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
title_fullStr Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
title_full_unstemmed Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
title_sort Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
dc.creator.none.fl_str_mv Argyelan, Miklos|||0000-0002-7254-1776
Deng, Zhi-De|||0000-0001-8925-0871
Ousdal, Olga Therese|||0000-0002-0728-3141
Oltedal, Leif|||0000-0003-3316-7950
Angulo, Brian
Baradits, Mate
Spitzberg, Andrew J.|||0000-0001-9379-2075
Kessler, Ute
Sartorius, Alexander|||0000-0002-1243-3693
Dols, Annemiek
Narr, Katherine L.|||0000-0002-9396-7936
Espinoza, Randall|||0000-0003-2895-4212
van Waarde, Jeroen A.|||0000-0001-6792-5727
Tendolkar, Indira|||0000-0003-3171-3671
van Eijndhoven, Philip
van Wingen, Guido|||0000-0003-3076-5891
Takamiya, Akihiro|||0000-0003-2985-6673
Kishimoto, Taishiro
Jorgensen, Martin Balslev|||0000-0002-1321-8901
Jorgensen, Anders
Paulson, Olaf B.|||0000-0001-7712-8596
Yrondi, Antoine|||0000-0002-2650-6080
Péran, Patrice
Soriano-Mas, Carles|||0000-0003-4574-6597
Cardoner, Narcís|||0000-0001-9633-0888
Cano, Marta|||0000-0003-0675-9483
van Diermen, Linda|||0000-0002-3178-4974
Schrijvers, Didier
Belge, Jean-Baptiste
Emsell, Louise|||0000-0003-0011-4158
Bouckaert, Filip
Vandenbulcke, Mathieu
Kiebs, Maximilian|||0000-0002-4216-2679
Hurlemann, René|||0000-0003-2628-565X
Mulders, Peter CR.|||0000-0002-7867-5513
Redlich, Ronny
Dannlowski, Udo|||0000-0002-0623-3759
Kavakbasi, Erhan
Kritzer, Michael D.
Ellard, Kristen K.
Camprodon, Joan Albert|||0000-0003-1282-9257
Petrides, Georgios
Malhotra, Anil K.
Abbott, Christopher|||0000-0001-6884-2464
author Argyelan, Miklos|||0000-0002-7254-1776
author_facet Argyelan, Miklos|||0000-0002-7254-1776
Deng, Zhi-De|||0000-0001-8925-0871
Ousdal, Olga Therese|||0000-0002-0728-3141
Oltedal, Leif|||0000-0003-3316-7950
Angulo, Brian
Baradits, Mate
Spitzberg, Andrew J.|||0000-0001-9379-2075
Kessler, Ute
Sartorius, Alexander|||0000-0002-1243-3693
Dols, Annemiek
Narr, Katherine L.|||0000-0002-9396-7936
Espinoza, Randall|||0000-0003-2895-4212
van Waarde, Jeroen A.|||0000-0001-6792-5727
Tendolkar, Indira|||0000-0003-3171-3671
van Eijndhoven, Philip
van Wingen, Guido|||0000-0003-3076-5891
Takamiya, Akihiro|||0000-0003-2985-6673
Kishimoto, Taishiro
Jorgensen, Martin Balslev|||0000-0002-1321-8901
Jorgensen, Anders
Paulson, Olaf B.|||0000-0001-7712-8596
Yrondi, Antoine|||0000-0002-2650-6080
Péran, Patrice
Soriano-Mas, Carles|||0000-0003-4574-6597
Cardoner, Narcís|||0000-0001-9633-0888
Cano, Marta|||0000-0003-0675-9483
van Diermen, Linda|||0000-0002-3178-4974
Schrijvers, Didier
Belge, Jean-Baptiste
Emsell, Louise|||0000-0003-0011-4158
Bouckaert, Filip
Vandenbulcke, Mathieu
Kiebs, Maximilian|||0000-0002-4216-2679
Hurlemann, René|||0000-0003-2628-565X
Mulders, Peter CR.|||0000-0002-7867-5513
Redlich, Ronny
Dannlowski, Udo|||0000-0002-0623-3759
Kavakbasi, Erhan
Kritzer, Michael D.
Ellard, Kristen K.
Camprodon, Joan Albert|||0000-0003-1282-9257
Petrides, Georgios
Malhotra, Anil K.
Abbott, Christopher|||0000-0001-6884-2464
author_role author
author2 Deng, Zhi-De|||0000-0001-8925-0871
Ousdal, Olga Therese|||0000-0002-0728-3141
Oltedal, Leif|||0000-0003-3316-7950
Angulo, Brian
Baradits, Mate
Spitzberg, Andrew J.|||0000-0001-9379-2075
Kessler, Ute
Sartorius, Alexander|||0000-0002-1243-3693
Dols, Annemiek
Narr, Katherine L.|||0000-0002-9396-7936
Espinoza, Randall|||0000-0003-2895-4212
van Waarde, Jeroen A.|||0000-0001-6792-5727
Tendolkar, Indira|||0000-0003-3171-3671
van Eijndhoven, Philip
van Wingen, Guido|||0000-0003-3076-5891
Takamiya, Akihiro|||0000-0003-2985-6673
Kishimoto, Taishiro
Jorgensen, Martin Balslev|||0000-0002-1321-8901
Jorgensen, Anders
Paulson, Olaf B.|||0000-0001-7712-8596
Yrondi, Antoine|||0000-0002-2650-6080
Péran, Patrice
Soriano-Mas, Carles|||0000-0003-4574-6597
Cardoner, Narcís|||0000-0001-9633-0888
Cano, Marta|||0000-0003-0675-9483
van Diermen, Linda|||0000-0002-3178-4974
Schrijvers, Didier
Belge, Jean-Baptiste
Emsell, Louise|||0000-0003-0011-4158
Bouckaert, Filip
Vandenbulcke, Mathieu
Kiebs, Maximilian|||0000-0002-4216-2679
Hurlemann, René|||0000-0003-2628-565X
Mulders, Peter CR.|||0000-0002-7867-5513
Redlich, Ronny
Dannlowski, Udo|||0000-0002-0623-3759
Kavakbasi, Erhan
Kritzer, Michael D.
Ellard, Kristen K.
Camprodon, Joan Albert|||0000-0003-1282-9257
Petrides, Georgios
Malhotra, Anil K.
Abbott, Christopher|||0000-0001-6884-2464
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
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author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Depression
Predictive markers
topic Depression
Predictive markers
description Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this causal depression network (CDN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis Principal Component Analysis (PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CDN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CDN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes (t = -2.35, p = 0.019). This evidence further supports that treatment interventions converge on a CDN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/293135
https://dx.doi.org/urn:doi:10.1038/s41380-023-02318-2
url https://ddd.uab.cat/record/293135
https://dx.doi.org/urn:doi:10.1038/s41380-023-02318-2
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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