Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression

Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differenc...

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Autores: Argyelan, Miklos|||0000-0002-7254-1776, Deng, Zhi-De|||0000-0001-8925-0871, Ousdal, Olga Therese|||0000-0002-0728-3141, Oltedal, Leif|||0000-0003-3316-7950, Angulo, Brian, Baradits, Mate, Spitzberg, Andrew J.|||0000-0001-9379-2075, Kessler, Ute, Sartorius, Alexander|||0000-0002-1243-3693, Dols, Annemiek, Narr, Katherine L.|||0000-0002-9396-7936, Espinoza, Randall|||0000-0003-2895-4212, van Waarde, Jeroen A.|||0000-0001-6792-5727, Tendolkar, Indira|||0000-0003-3171-3671, van Eijndhoven, Philip, van Wingen, Guido|||0000-0003-3076-5891, Takamiya, Akihiro|||0000-0003-2985-6673, Kishimoto, Taishiro, Jorgensen, Martin Balslev|||0000-0002-1321-8901, Jorgensen, Anders, Paulson, Olaf B.|||0000-0001-7712-8596, Yrondi, Antoine|||0000-0002-2650-6080, Péran, Patrice, Soriano-Mas, Carles|||0000-0003-4574-6597, Cardoner, Narcís|||0000-0001-9633-0888, Cano, Marta|||0000-0003-0675-9483, van Diermen, Linda|||0000-0002-3178-4974, Schrijvers, Didier, Belge, Jean-Baptiste, Emsell, Louise|||0000-0003-0011-4158, Bouckaert, Filip, Vandenbulcke, Mathieu, Kiebs, Maximilian|||0000-0002-4216-2679, Hurlemann, René|||0000-0003-2628-565X, Mulders, Peter CR.|||0000-0002-7867-5513, Redlich, Ronny, Dannlowski, Udo|||0000-0002-0623-3759, Kavakbasi, Erhan, Kritzer, Michael D., Ellard, Kristen K., Camprodon, Joan Albert|||0000-0003-1282-9257, Petrides, Georgios, Malhotra, Anil K., Abbott, Christopher|||0000-0001-6884-2464
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:293135
Acceso en línea:https://ddd.uab.cat/record/293135
https://dx.doi.org/urn:doi:10.1038/s41380-023-02318-2
Access Level:acceso abierto
Palabra clave:Depression
Predictive markers
Descripción
Sumario:Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this causal depression network (CDN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis Principal Component Analysis (PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CDN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CDN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes (t = -2.35, p = 0.019). This evidence further supports that treatment interventions converge on a CDN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.

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