Obesity and the gut microbiota: implications of neuroendocrine and immune signaling

Obesity is a major health challenge due to its high prevalence and associated comorbidities. The excessive intake of a diet rich in fat and sugars leads to a persistent imbalance between energy intake and energy expenditure, which increases adiposity. Here, we provide an update on relevant diet-micr...

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Autores: Romaní Pérez, Marina, Líebana García, Rebeca, Flor Duro, Alejandra, Bonillo Jiménez, Daniel, Bullich Vilarrubias, Clara, Olivares, Marta, Sanz Herranz, Yolanda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/366369
Acceso en línea:http://hdl.handle.net/10261/366369
https://api.elsevier.com/content/abstract/scopus_id/85201413065
Access Level:acceso abierto
Palabra clave:Diet
Enteroendocrine hormones
Gut microbiota
Inflammation
Obesity
obesity
inflammation
diet
gastrointestinal hormones
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spelling Obesity and the gut microbiota: implications of neuroendocrine and immune signalingRomaní Pérez, MarinaLíebana García, RebecaFlor Duro, AlejandraBonillo Jiménez, DanielBullich Vilarrubias, ClaraOlivares, MartaSanz Herranz, YolandaDietEnteroendocrine hormonesGut microbiotaInflammationObesityobesityinflammationdietgastrointestinal hormonesObesity is a major health challenge due to its high prevalence and associated comorbidities. The excessive intake of a diet rich in fat and sugars leads to a persistent imbalance between energy intake and energy expenditure, which increases adiposity. Here, we provide an update on relevant diet-microbe-host interactions contributing to or protecting from obesity. In particular, we focus on how unhealthy diets shape the gut microbiota and thus impact crucial intestinal neuroendocrine and immune system functions. We describe how these interactions promote dysfunction in gut-to-brain neuroendocrine pathways involved in food intake control and postprandial metabolism and elevate the intestinal proinflammatory tone, promoting obesity and metabolic complications. In addition, we provide examples of how this knowledge may inspire microbiome-based interventions, such as fecal microbiota transplants, probiotics, and biotherapeutics, to effectively combat obesity-related disorders. We also discuss the current limitations and gaps in knowledge of gut microbiota research in obesity.This study has been funded by the Spanish Ministry of Science and Innovation (Grant PID2020-119536RB-I00), the European Commission – NextGeneration EU, through the CSIC Interdisciplinary Thematic Platform (PTI+) NEURO-AGINGl+. “(PTI-NEURO-AGING+)” and the “Severo Ochoa” grant of National Agency for Research (AEI)- Spanish Ministry of Science and Innovation (Ref. CEX2021-001189-S). The FPI contract to D. Bonillo from MICIN is acknowledged.Peer reviewedFederation of European Biochemical SocietiesMinisterio de Ciencia e Innovación (España)European CommissionConsejo Superior de Investigaciones Científicas (España)Agencia Estatal de Investigación (España)Sanz Herranz, Yolanda [0000-0002-1615-1976]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/366369https://api.elsevier.com/content/abstract/scopus_id/85201413065reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119536RB-I00The FEBS journalhttps://doi.org/10.1111/febs.17249Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3663692026-05-22T06:33:51Z
dc.title.none.fl_str_mv Obesity and the gut microbiota: implications of neuroendocrine and immune signaling
title Obesity and the gut microbiota: implications of neuroendocrine and immune signaling
spellingShingle Obesity and the gut microbiota: implications of neuroendocrine and immune signaling
Romaní Pérez, Marina
Diet
Enteroendocrine hormones
Gut microbiota
Inflammation
Obesity
obesity
inflammation
diet
gastrointestinal hormones
title_short Obesity and the gut microbiota: implications of neuroendocrine and immune signaling
title_full Obesity and the gut microbiota: implications of neuroendocrine and immune signaling
title_fullStr Obesity and the gut microbiota: implications of neuroendocrine and immune signaling
title_full_unstemmed Obesity and the gut microbiota: implications of neuroendocrine and immune signaling
title_sort Obesity and the gut microbiota: implications of neuroendocrine and immune signaling
dc.creator.none.fl_str_mv Romaní Pérez, Marina
Líebana García, Rebeca
Flor Duro, Alejandra
Bonillo Jiménez, Daniel
Bullich Vilarrubias, Clara
Olivares, Marta
Sanz Herranz, Yolanda
author Romaní Pérez, Marina
author_facet Romaní Pérez, Marina
Líebana García, Rebeca
Flor Duro, Alejandra
Bonillo Jiménez, Daniel
Bullich Vilarrubias, Clara
Olivares, Marta
Sanz Herranz, Yolanda
author_role author
author2 Líebana García, Rebeca
Flor Duro, Alejandra
Bonillo Jiménez, Daniel
Bullich Vilarrubias, Clara
Olivares, Marta
Sanz Herranz, Yolanda
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
European Commission
Consejo Superior de Investigaciones Científicas (España)
Agencia Estatal de Investigación (España)
Sanz Herranz, Yolanda [0000-0002-1615-1976]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Diet
Enteroendocrine hormones
Gut microbiota
Inflammation
Obesity
obesity
inflammation
diet
gastrointestinal hormones
topic Diet
Enteroendocrine hormones
Gut microbiota
Inflammation
Obesity
obesity
inflammation
diet
gastrointestinal hormones
description Obesity is a major health challenge due to its high prevalence and associated comorbidities. The excessive intake of a diet rich in fat and sugars leads to a persistent imbalance between energy intake and energy expenditure, which increases adiposity. Here, we provide an update on relevant diet-microbe-host interactions contributing to or protecting from obesity. In particular, we focus on how unhealthy diets shape the gut microbiota and thus impact crucial intestinal neuroendocrine and immune system functions. We describe how these interactions promote dysfunction in gut-to-brain neuroendocrine pathways involved in food intake control and postprandial metabolism and elevate the intestinal proinflammatory tone, promoting obesity and metabolic complications. In addition, we provide examples of how this knowledge may inspire microbiome-based interventions, such as fecal microbiota transplants, probiotics, and biotherapeutics, to effectively combat obesity-related disorders. We also discuss the current limitations and gaps in knowledge of gut microbiota research in obesity.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/366369
https://api.elsevier.com/content/abstract/scopus_id/85201413065
url http://hdl.handle.net/10261/366369
https://api.elsevier.com/content/abstract/scopus_id/85201413065
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119536RB-I00
The FEBS journal
https://doi.org/10.1111/febs.17249
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Federation of European Biochemical Societies
publisher.none.fl_str_mv Federation of European Biochemical Societies
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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