Heart Failure after Cardiac Surgery: The Role of Halogenated Agents, Myocardial Conditioning and Oxidative Stress.
Heart disease requires a surgical approach sometimes. Cardiac-surgery patients develop heart failure associated with ischemia induced during extracorporeal circulation. This complication could be decreased with anesthetic drugs. The cardioprotective effects of halogenated agents are based on pre- an...
| Authors: | , , |
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| Format: | article |
| Publication Date: | 2022 |
| Country: | España |
| Institution: | Instituto de Salud Carlos III (ISCIII) |
| Repository: | Repisalud |
| Language: | English |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/18588 |
| Online Access: | http://hdl.handle.net/20.500.12105/18588 |
| Access Level: | Open access |
| Keyword: | ACDHUVV-16 halogenated heart failure postconditioning preconditioning Anesthetics, Inhalation Cardiac Surgical Procedures Cardiomyopathies Cardiotonic Agents Heart Failure Humans Hydrocarbons, Halogenated Isoflurane Myocardium Oxidative Stress Propofol Sevoflurane |
| Summary: | Heart disease requires a surgical approach sometimes. Cardiac-surgery patients develop heart failure associated with ischemia induced during extracorporeal circulation. This complication could be decreased with anesthetic drugs. The cardioprotective effects of halogenated agents are based on pre- and postconditioning (sevoflurane, desflurane, or isoflurane) compared to intravenous hypnotics (propofol). We tried to put light on the shadows walking through the line of the halogenated anesthetic drugs' effects in several enzymatic routes and oxidative stress, waiting for the final results of the ACDHUVV-16 clinical trial regarding the genetic modulation of this kind of drugs. |
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