Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experience

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, p...

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Authors: Domínguez-Moreno, Marta, Chimenea, Ángel, García-Díaz, Lutgardo, Antiñolo, Guillermo
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/351423
Online Access:http://hdl.handle.net/10261/351423
Access Level:Open access
Keyword:Fetal surgery
Ex utero intrapartum treatment
Maternal outcomes
Neonatal outcomes
id ES_823aa229bdd7b4cd54bd8a5ad6fdde57
oai_identifier_str oai:digital.csic.es:10261/351423
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experience
title Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experience
spellingShingle Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experience
Domínguez-Moreno, Marta
Fetal surgery
Ex utero intrapartum treatment
Maternal outcomes
Neonatal outcomes
title_short Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experience
title_full Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experience
title_fullStr Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experience
title_full_unstemmed Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experience
title_sort Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experience
dc.creator.none.fl_str_mv Domínguez-Moreno, Marta
Chimenea, Ángel
García-Díaz, Lutgardo
Antiñolo, Guillermo
author Domínguez-Moreno, Marta
author_facet Domínguez-Moreno, Marta
Chimenea, Ángel
García-Díaz, Lutgardo
Antiñolo, Guillermo
author_role author
author2 Chimenea, Ángel
García-Díaz, Lutgardo
Antiñolo, Guillermo
author2_role author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Fetal surgery
Ex utero intrapartum treatment
Maternal outcomes
Neonatal outcomes
topic Fetal surgery
Ex utero intrapartum treatment
Maternal outcomes
Neonatal outcomes
description © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/351423
url http://hdl.handle.net/10261/351423
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1186/s12884-023-06129-9

dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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spelling Maternal and obstetric outcomes after Ex-Utero Intrapartum Treatment (EXIT): a single center experienceDomínguez-Moreno, MartaChimenea, ÁngelGarcía-Díaz, LutgardoAntiñolo, GuillermoFetal surgeryEx utero intrapartum treatmentMaternal outcomesNeonatal outcomes© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.[Background] The Ex-utero Intrapartum Treatment (EXIT) is a procedure developed to manage a range of fetal conditions, aiming to ensure the maintenance of neonatal airway and preserving the feto-placental circulation. Its goal is to enhance the neonatal ability to successfully transition and adapt to postnatal life, thereby reducing perinatal morbidity and mortality. However, EXIT has been associated with a high risk of maternal complications. This paper provides an overview of the indications and characteristics of the EXIT procedure, as well as the obstetric outcomes and maternal complications.[Methods] A retrospective analysis was conducted on a cohort of patients undergoing EXIT at our center between January 2007 and December 2022. Maternal outcomes, including demographic information, data related to the surgical procedure, surgical complications, and postoperative complications were analyzed. To assess the severity of the surgical complications, a modified Clavien-Dindo classification was used. Comparative analysis was performed by randomly selecting a sample from elective cesarean deliveries performed at our center.[Results] A total of 34 EXIT procedures were performed. According to the modified Clavien-Dindo classification, we observed no major complications, while minor maternal complications were present in 2.94% of cases. Compared to elective cesarean deliveries (n = 350), there were no significant differences in terms of maternal complications, highlighting the similarity observed in the mean decrease in postoperative hemoglobin (1.15 g/dL in EXIT vs. 1.2 g/dL in elective cesarean deliveries, p = 0.94). In EXIT group, there was a higher rate of polyhydramnios (26.47% vs 6.59%, p < 0.001), as well as the need for amnioreduction (14.71% vs 0%, p = 0.001) and preterm delivery (32.35% vs 6.02%, p = 0.001). There were no cases of endometritis, post-procedural fever, or abruptio placentae following EXIT.[Conclusions] EXIT can be considered a safe procedure when performed under adequate conditions, including appropriate uterine access and proper anesthetic management. In our series, EXIT procedure was not associated with a higher incidence of maternal complications when compared to elective cesarean delivery.[Trial registration] Retrospectively registered.Peer reviewedBioMed CentralConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/351423reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1186/s12884-023-06129-9Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3514232026-05-22T06:33:51Z
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