MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population

Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consu...

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Authors: Barragán, Rocío, Coltell, Óscar, Asensio, Eva M., Francés, Francesc, Sorlí, José V., Estruch Riba, Ramon, Salas-Huetos, Albert, Ordovás, José María, Corella Piquer, Dolores
Format: article
Status:Published version
Publication Date:2016
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/111023
Online Access:https://hdl.handle.net/2445/111023
Access Level:Open access
Keyword:Micro RNAs
Cuina mediterrània
Consum d'alcohol
Genètica molecular
MicroRNAs
Mediterranean cooking
Drinking of alcoholic beverages
Molecular genetics
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spelling MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean populationBarragán, RocíoColtell, ÓscarAsensio, Eva M.Francés, FrancescSorlí, José V.Estruch Riba, RamonSalas-Huetos, AlbertOrdovás, José MaríaCorella Piquer, DoloresMicro RNAsCuina mediterràniaConsum d'alcoholGenètica molecularMicroRNAsMediterranean cookingDrinking of alcoholic beveragesMolecular geneticsRecently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvención con DIeta MEDiterránea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 ± 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake, this being higher in GG subjects (5.2 ± 0.4 in AA, 5.9 ± 0.5 in AG and 9.1 ± 1.8 g/day in GG; padjusted = 0.019). We also found a statistically-significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (>2 drinks/day in men and >1 in women): 5.9% in AA versus 17.5% in GG; padjusted < 0.001. In the sensitivity analysis, this association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption.MDPI2017201720162017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion18 p.application/pdfhttps://hdl.handle.net/2445/111023Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms17081338International Journal of Molecular Sciences, 2016, vol. 17, num. 8, p. E1338https://doi.org/10.3390/ijms17081338cc-by (c) Barragán, Rocío et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1110232026-05-29T05:05:01Z
dc.title.none.fl_str_mv MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population
title MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population
spellingShingle MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population
Barragán, Rocío
Micro RNAs
Cuina mediterrània
Consum d'alcohol
Genètica molecular
MicroRNAs
Mediterranean cooking
Drinking of alcoholic beverages
Molecular genetics
title_short MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population
title_full MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population
title_fullStr MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population
title_full_unstemmed MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population
title_sort MicroRNAs and drinking: association between the Pre-miR-27a rs895819 polymorphism and alcohol consumption in a Mediterranean population
dc.creator.none.fl_str_mv Barragán, Rocío
Coltell, Óscar
Asensio, Eva M.
Francés, Francesc
Sorlí, José V.
Estruch Riba, Ramon
Salas-Huetos, Albert
Ordovás, José María
Corella Piquer, Dolores
author Barragán, Rocío
author_facet Barragán, Rocío
Coltell, Óscar
Asensio, Eva M.
Francés, Francesc
Sorlí, José V.
Estruch Riba, Ramon
Salas-Huetos, Albert
Ordovás, José María
Corella Piquer, Dolores
author_role author
author2 Coltell, Óscar
Asensio, Eva M.
Francés, Francesc
Sorlí, José V.
Estruch Riba, Ramon
Salas-Huetos, Albert
Ordovás, José María
Corella Piquer, Dolores
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Micro RNAs
Cuina mediterrània
Consum d'alcohol
Genètica molecular
MicroRNAs
Mediterranean cooking
Drinking of alcoholic beverages
Molecular genetics
topic Micro RNAs
Cuina mediterrània
Consum d'alcohol
Genètica molecular
MicroRNAs
Mediterranean cooking
Drinking of alcoholic beverages
Molecular genetics
description Recently, microRNAs (miRNA) have been proposed as regulators in the different processes involved in alcohol intake, and differences have been found in the miRNA expression profile in alcoholics. However, no study has focused on analyzing polymorphisms in genes encoding miRNAs and daily alcohol consumption at the population level. Our aim was to investigate the association between a functional polymorphism in the pre-miR-27a (rs895819 A>G) gene and alcohol consumption in an elderly population. We undertook a cross-sectional study of PREvención con DIeta MEDiterránea (PREDIMED)-Valencia participants (n = 1007, including men and women aged 67 ± 7 years) and measured their alcohol consumption (total and alcoholic beverages) through a validated questionnaire. We found a strong association between the pre-miR-27a polymorphism and total alcohol intake, this being higher in GG subjects (5.2 ± 0.4 in AA, 5.9 ± 0.5 in AG and 9.1 ± 1.8 g/day in GG; padjusted = 0.019). We also found a statistically-significant association of the pre-miR-27a polymorphism with the risk of having a high alcohol intake (>2 drinks/day in men and >1 in women): 5.9% in AA versus 17.5% in GG; padjusted < 0.001. In the sensitivity analysis, this association was homogeneous for sex, obesity and Mediterranean diet adherence. In conclusion, we report for the first time a significant association between a miRNA polymorphism (rs895819) and daily alcohol consumption.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/111023
url https://hdl.handle.net/2445/111023
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms17081338
International Journal of Molecular Sciences, 2016, vol. 17, num. 8, p. E1338
https://doi.org/10.3390/ijms17081338
dc.rights.none.fl_str_mv cc-by (c) Barragán, Rocío et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Barragán, Rocío et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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