N-Heterocyclic Carbene-Carbodiimide (NHC-CDI) Betaines as Organocatalysts for β-Butyrolactone Polymerization: Synthesis of Green PHB Plasticizers with Tailored Molecular Weights

The manufacture of poly(3-hydroxybutyrate) (PHB) stands out as a promising alternative to traditional plastics. This polymer is usually produced by bacteria-based biotechnology or metal-catalyzed ring-opening polymerization (ROP) of β-butyrolactone (β-BL). Nevertheless, commercial PHB suffers from d...

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Detalles Bibliográficos
Autores: Sánchez-Roa, David, Sessini, Valentina, Mosquera, Marta E.G., Cámpora, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/356363
Acceso en línea:http://hdl.handle.net/10261/356363
https://api.elsevier.com/content/abstract/scopus_id/85184811821
Access Level:acceso abierto
Palabra clave:betaines
Flory−Schulz MW distribution
organocatalysis
ring-opening polymerization
PHB
plasticizers
Descripción
Sumario:The manufacture of poly(3-hydroxybutyrate) (PHB) stands out as a promising alternative to traditional plastics. This polymer is usually produced by bacteria-based biotechnology or metal-catalyzed ring-opening polymerization (ROP) of β-butyrolactone (β-BL). Nevertheless, commercial PHB suffers from different issues, from poor processability to high production costs. Herein, we report the chemical synthesis of PHB from the ROP of rac-β-butyrolactone promoted by a zwitterionic organocatalyst, an N-heterocyclic carbene-carbodiimide (NHC-CDI) betaine adduct. This reaction has been investigated by a combination of experimental and computational methods. The catalyst cleaves the β-BL via nucleophilic displacement of the C-O(carboxyl) bond followed by intramolecular elimination to give protonated betaine-crotonate ion pairs, the active polymerization initiators. Polymer growth is propagated and controlled by these betaine ion pairs, which render amorphous low-molecular-weight PHBs by an unusual mechanism with rapid chain transfer to the monomer regime, analogous to the well-known mechanism of ethylene oligomerization with late transition-metal catalysts. The resulting material is suitable as a biodegradable and biocompatible plasticizer for commercial bacterial or synthetic PHB. Perfect compatibility between the matrix and the additive and a significant reduction of the crystallinity resulted in a more flexible and resilient material.