Increased mortality after kidney transplantation in mildly frail recipients

Physical Frailty Phenotype (PFP) is the most used frailty instrument among kidney transplant recipients, classifying patients as pre-frail if they have 1-2 criteria and as frail if they have ≥3. However, different definitions of robustness have been used among renal patients, including only those wh...

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Detalles Bibliográficos
Autores: Pérez-Sáez, María José|||0000-0002-8601-2699, Arias Cabrales, Carlos E|||0000-0002-1729-8152, Redondo-Pachón, Dolores|||0000-0002-0458-0052, Burballa, Carla|||0000-0002-0091-1459, Buxeda, Anna|||0000-0001-7305-3259, Bach Pascual, Anna|||0000-0003-0571-6131, Faura, Anna|||0000-0002-1440-3922, Junyent, Ernestina, Marco, Ester|||0000-0002-3412-0356, Rodríguez-Mañas, Leocadio|||0000-0002-6551-1333, Crespo, Marta|||0000-0001-6992-6379, Pascual, Julio|||0000-0002-4735-7838
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:268236
Acceso en línea:https://ddd.uab.cat/record/268236
https://dx.doi.org/urn:doi:10.1093/ckj/sfac159
Access Level:acceso abierto
Palabra clave:Frailty phenotype
Fried
Survival
Transplant
Descripción
Sumario:Physical Frailty Phenotype (PFP) is the most used frailty instrument among kidney transplant recipients, classifying patients as pre-frail if they have 1-2 criteria and as frail if they have ≥3. However, different definitions of robustness have been used among renal patients, including only those who have 0 criteria, or those with 0-1 criteria. Our aim was to determine the impact of one PFP criterion on transplant outcomes. We undertook a retrospective study of 296 kidney transplant recipients who had been evaluated for frailty by PFP at the time of evaluating for transplantation. Only 30.4% of patients had 0 criteria, and an additional 42.9% showed one PFP criterion. As PFP score increased, a higher percentage of women and cerebrovascular disease were found. Recipients with 0-1 criteria had lower 1-year mortality after transplant than those with ≥2 (1.8% vs 10.1%), but this difference was already present when we only considered those who scored 0 (mortality 1.1%) and 1 (mortality 2.4%) separately. The multivariable analysis confirmed that one PFP criterion was associated to a higher risk of patient death after kidney transplantation [hazard ratio 3.52 (95% confidence interval 1.03-15.9)]. Listed kidney transplant candidates frequently show only one PFP frailty criterion. This has an independent impact on patient survival after transplantation.

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