Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease

Villacieros Álvarez, Javier; Espejo Ruiz, Carmen; Arrambide, Georgina; Dinoto, Alessandro; Mulero Carrillo, Patricia; Rubio Flores, Laura; Nieto González, Pablo; Alcalá, Carmen; Meca Lallana, José E.; Millan Pascual, Jorge; Martínez García, Pedro; Bernard Valnet, Raphael; González Suárez, Inés; Orviz García, Aída; Téllez Pérez, Raquel; Navarro Cantó, Laura; Presas Rodríguez, Silvia; Martínez Yélamos, Sergio; Cuello, Juan Pablo; Alonso Torres, Ana María; Piñar Morales, Raquel; Álvarez Bravo, Gary; Benyahya, Lakhdar; Trouillet Assant, Sophie; Dyon Tafan, Virginie; Froment Tilikete, Caroline; Ruet, Aurélie; Bourre, Bertrand; Deschamps, Romain; Papeix, Caroline; Maillart, Elisabeth; Kerschen, Philippe; Ayrignac, Xavier; Rovira, Àlex; Auger Acosta, Cristina; Audoin, Bertrand; Montalbán Gairín, Xavier; Tintoré Subirana, Mar; Mariotto, Sara; Cobo Calvo, Álvaro; Marignier, Romain

Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease

Objectives To characterize the serum cytokine profile in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at onset and during follow-up and assess their utility for predicting relapses and disability. Methods This retrospective multicentric cohort study included patients aged...

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Autores:	Villacieros Álvarez, Javier, Espejo Ruiz, Carmen, Arrambide, Georgina, Dinoto, Alessandro, Mulero Carrillo, Patricia, Rubio Flores, Laura, Nieto González, Pablo, Alcalá, Carmen, Meca Lallana, José E., Millan Pascual, Jorge, Martínez García, Pedro, Bernard Valnet, Raphael, González Suárez, Inés, Orviz García, Aída, Téllez Pérez, Raquel, Navarro Cantó, Laura, Presas Rodríguez, Silvia, Martínez Yélamos, Sergio, Cuello, Juan Pablo, Alonso Torres, Ana María, Piñar Morales, Raquel, Álvarez Bravo, Gary, Benyahya, Lakhdar, Trouillet Assant, Sophie, Dyon Tafan, Virginie, Froment Tilikete, Caroline, Ruet, Aurélie, Bourre, Bertrand, Deschamps, Romain, Papeix, Caroline, Maillart, Elisabeth, Kerschen, Philippe, Ayrignac, Xavier, Rovira, Àlex, Auger Acosta, Cristina, Audoin, Bertrand, Montalbán Gairín, Xavier, Tintoré Subirana, Mar, Mariotto, Sara, Cobo Calvo, Álvaro, Marignier, Romain
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2025
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/221373
Acceso en línea:	https://hdl.handle.net/2445/221373
Access Level:	acceso abierto
Palabra clave:	Neuroimmunologia Autoanticossos Neuroimmunology Autoantibodies

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spelling	Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated DiseaseVillacieros Álvarez, JavierEspejo Ruiz, CarmenArrambide, GeorginaDinoto, AlessandroMulero Carrillo, PatriciaRubio Flores, LauraNieto González, PabloAlcalá, CarmenMeca Lallana, José E.Millan Pascual, JorgeMartínez García, PedroBernard Valnet, RaphaelGonzález Suárez, InésOrviz García, AídaTéllez Pérez, RaquelNavarro Cantó, LauraPresas Rodríguez, SilviaMartínez Yélamos, SergioCuello, Juan PabloAlonso Torres, Ana MaríaPiñar Morales, RaquelÁlvarez Bravo, GaryBenyahya, LakhdarTrouillet Assant, SophieDyon Tafan, VirginieFroment Tilikete, CarolineRuet, AurélieBourre, BertrandDeschamps, RomainPapeix, CarolineMaillart, ElisabethKerschen, PhilippeAyrignac, XavierRovira, ÀlexAuger Acosta, CristinaAudoin, BertrandMontalbán Gairín, XavierTintoré Subirana, MarMariotto, SaraCobo Calvo, ÁlvaroMarignier, RomainNeuroimmunologiaAutoanticossosNeuroimmunologyAutoantibodiesObjectives To characterize the serum cytokine profile in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at onset and during follow-up and assess their utility for predicting relapses and disability. Methods This retrospective multicentric cohort study included patients aged 16 years and older meeting MOGAD 2023 criteria, with serum samples collected at baseline (<= 3 months from disease onset) and follow-up (>= 6 months from the baseline), and age-matched and time to sampling-matched patients with multiple sclerosis (MS). Eleven cytokines were assessed using the ELLA system. Data comparisons and statistical analyses between cytokine levels and clinical outcomes were performed. Results Eighty-eight patients with MOGAD and 32 patients with MS were included. Patients with MOGAD showed higher IL6 (p = 0.036), IL8 (p = 0.012), and IL18 (p = 0.026) baseline levels compared with those with MS, in non-optic neuritis (ON) presentations. BAFF values increased over time, especially in patients with MOGAD treated with anti-CD20 (p = 0.002). Baseline BAFF, CXCL10, IL10, and IL8 levels correlated with disease severity at MOGAD onset (all p < 0.05). Finally, higher baseline BAFF levels predicted lower risk of relapses (hazard ratio 0.41 [0.19; 0.89], p = 0.024). Discussion This study suggests a proinflammatory Th17-dominant profile in non-ON MOGAD patients, with a novel finding of a potential protective role of BAFF on relapses. These results shed new light on the pathogenesis of MOGAD, potentially guiding therapeutic decisions.Ovid Technologies (Wolters Kluwer Health)2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/221373Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1212/NXI.0000000000200362Neurology Neuroimmunology & Neuroinflammation, 2025, vol. 12, num. 2https://doi.org/10.1212/NXI.0000000000200362cc-by (c) Villacieros Álvarez et al., 2025http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2213732026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease
title	Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease
spellingShingle	Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease Villacieros Álvarez, Javier Neuroimmunologia Autoanticossos Neuroimmunology Autoantibodies
title_short	Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease
title_full	Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease
title_fullStr	Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease
title_full_unstemmed	Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease
title_sort	Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease
dc.creator.none.fl_str_mv	Villacieros Álvarez, Javier Espejo Ruiz, Carmen Arrambide, Georgina Dinoto, Alessandro Mulero Carrillo, Patricia Rubio Flores, Laura Nieto González, Pablo Alcalá, Carmen Meca Lallana, José E. Millan Pascual, Jorge Martínez García, Pedro Bernard Valnet, Raphael González Suárez, Inés Orviz García, Aída Téllez Pérez, Raquel Navarro Cantó, Laura Presas Rodríguez, Silvia Martínez Yélamos, Sergio Cuello, Juan Pablo Alonso Torres, Ana María Piñar Morales, Raquel Álvarez Bravo, Gary Benyahya, Lakhdar Trouillet Assant, Sophie Dyon Tafan, Virginie Froment Tilikete, Caroline Ruet, Aurélie Bourre, Bertrand Deschamps, Romain Papeix, Caroline Maillart, Elisabeth Kerschen, Philippe Ayrignac, Xavier Rovira, Àlex Auger Acosta, Cristina Audoin, Bertrand Montalbán Gairín, Xavier Tintoré Subirana, Mar Mariotto, Sara Cobo Calvo, Álvaro Marignier, Romain
author	Villacieros Álvarez, Javier
author_facet	Villacieros Álvarez, Javier Espejo Ruiz, Carmen Arrambide, Georgina Dinoto, Alessandro Mulero Carrillo, Patricia Rubio Flores, Laura Nieto González, Pablo Alcalá, Carmen Meca Lallana, José E. Millan Pascual, Jorge Martínez García, Pedro Bernard Valnet, Raphael González Suárez, Inés Orviz García, Aída Téllez Pérez, Raquel Navarro Cantó, Laura Presas Rodríguez, Silvia Martínez Yélamos, Sergio Cuello, Juan Pablo Alonso Torres, Ana María Piñar Morales, Raquel Álvarez Bravo, Gary Benyahya, Lakhdar Trouillet Assant, Sophie Dyon Tafan, Virginie Froment Tilikete, Caroline Ruet, Aurélie Bourre, Bertrand Deschamps, Romain Papeix, Caroline Maillart, Elisabeth Kerschen, Philippe Ayrignac, Xavier Rovira, Àlex Auger Acosta, Cristina Audoin, Bertrand Montalbán Gairín, Xavier Tintoré Subirana, Mar Mariotto, Sara Cobo Calvo, Álvaro Marignier, Romain
author_role	author
author2	Espejo Ruiz, Carmen Arrambide, Georgina Dinoto, Alessandro Mulero Carrillo, Patricia Rubio Flores, Laura Nieto González, Pablo Alcalá, Carmen Meca Lallana, José E. Millan Pascual, Jorge Martínez García, Pedro Bernard Valnet, Raphael González Suárez, Inés Orviz García, Aída Téllez Pérez, Raquel Navarro Cantó, Laura Presas Rodríguez, Silvia Martínez Yélamos, Sergio Cuello, Juan Pablo Alonso Torres, Ana María Piñar Morales, Raquel Álvarez Bravo, Gary Benyahya, Lakhdar Trouillet Assant, Sophie Dyon Tafan, Virginie Froment Tilikete, Caroline Ruet, Aurélie Bourre, Bertrand Deschamps, Romain Papeix, Caroline Maillart, Elisabeth Kerschen, Philippe Ayrignac, Xavier Rovira, Àlex Auger Acosta, Cristina Audoin, Bertrand Montalbán Gairín, Xavier Tintoré Subirana, Mar Mariotto, Sara Cobo Calvo, Álvaro Marignier, Romain
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Neuroimmunologia Autoanticossos Neuroimmunology Autoantibodies
topic	Neuroimmunologia Autoanticossos Neuroimmunology Autoantibodies
description	Objectives To characterize the serum cytokine profile in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) at onset and during follow-up and assess their utility for predicting relapses and disability. Methods This retrospective multicentric cohort study included patients aged 16 years and older meeting MOGAD 2023 criteria, with serum samples collected at baseline (<= 3 months from disease onset) and follow-up (>= 6 months from the baseline), and age-matched and time to sampling-matched patients with multiple sclerosis (MS). Eleven cytokines were assessed using the ELLA system. Data comparisons and statistical analyses between cytokine levels and clinical outcomes were performed. Results Eighty-eight patients with MOGAD and 32 patients with MS were included. Patients with MOGAD showed higher IL6 (p = 0.036), IL8 (p = 0.012), and IL18 (p = 0.026) baseline levels compared with those with MS, in non-optic neuritis (ON) presentations. BAFF values increased over time, especially in patients with MOGAD treated with anti-CD20 (p = 0.002). Baseline BAFF, CXCL10, IL10, and IL8 levels correlated with disease severity at MOGAD onset (all p < 0.05). Finally, higher baseline BAFF levels predicted lower risk of relapses (hazard ratio 0.41 [0.19; 0.89], p = 0.024). Discussion This study suggests a proinflammatory Th17-dominant profile in non-ON MOGAD patients, with a novel finding of a potential protective role of BAFF on relapses. These results shed new light on the pathogenesis of MOGAD, potentially guiding therapeutic decisions.
publishDate	2025
dc.date.none.fl_str_mv	2025 2025 2025 2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/221373
url	https://hdl.handle.net/2445/221373
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1212/NXI.0000000000200362 Neurology Neuroimmunology & Neuroinflammation, 2025, vol. 12, num. 2 https://doi.org/10.1212/NXI.0000000000200362
dc.rights.none.fl_str_mv	cc-by (c) Villacieros Álvarez et al., 2025 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Villacieros Álvarez et al., 2025 http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	7 p. application/pdf
dc.publisher.none.fl_str_mv	Ovid Technologies (Wolters Kluwer Health)
publisher.none.fl_str_mv	Ovid Technologies (Wolters Kluwer Health)
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,811543

Profile and Usefulness of Serum Cytokines to Predict Prognosis in Myelin Oligodendrocyte Glycoprotein Antibody−Associated Disease

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