Characteristics of Patients with Heart Failure and Advanced Chronic Kidney Disease (Stages 4-5) Not Undergoing Renal Replacement Therapy (ERCA-IC Study)

Background: Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. Methods: A retrospective study of 217 patients with advanced CKD (stages 4 and 5) wh...

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Authors: Valdivielso Moré, Sandra|||0000-0002-0400-3247, Vicente Elcano, Miren, Garcia Alonso, Anna, Pascual Sanchez, Sergi, Galceran Herrera, Isabel, Barbosa, Francesc, Belarte Tornero, Laia Carla|||0000-0003-2774-1290, Ruiz Bustillo, Sonia|||0000-0002-6074-914X, Morales, Ronald O., Barrios, Clara|||0000-0003-0492-4107, Vime Jubany, Joan, Farré, Núria|||0000-0003-3110-6572
Format: article
Publication Date:2023
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:326666
Online Access:https://ddd.uab.cat/record/326666
https://dx.doi.org/urn:doi:10.3390/jcm12062339
Access Level:Open access
Keyword:Advanced chronic kidney disease
Cardiorenal
Heart failure
Kidney dysfunction
Prognosis
Description
Summary:Background: Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. Methods: A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo renal replacement therapy (RRT). The patients were followed up for two years. The primary outcome was all-cause death or the need for RRT. Results: Forty percent of patients had a history of HF. The mean age was 78.2 ± 8.8 years and the mean eGFR was 18.4 ± 5.5 mL/min/1.73 m. The presence of previous HF identified a subgroup of high-risk patients with a high prevalence of cardiovascular comorbidities and was significantly associated with the composite endpoint of all-cause hospitalization or need for RRT (66.7% vs. 53.1%, HR 95% CI 1.62 (1.04-2.52), p = 0.034). No differences were found in the need for RRT (27.6% vs. 32.2%, p = 0.46). Nineteen patients without HF at baseline developed HF during the follow-up and all-cause death was numerically higher (36.8 vs. 19.8%, p = 0.1). Conclusions: Patients with advanced CKD have a high prevalence of HF. The presence of previous HF identified a high-risk population with a worse prognosis that required close follow-up.

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