Characteristics of patients with heart failure and advanced chronic kidney disease (Stages 4–5) not undergoing renal replacement therapy (ERCA-IC Study)

Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo ren...

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Detalles Bibliográficos
Autores: Valdivielso Moré, Sandra, Vicente Elcano, Miren, García Alonso, Anna, Pascual Sanchez, Sergi, Galceran Herrera, Isabel, Barbosa Puig, Francisco, Belarte Tornero, Laia Carla, Ruiz-Bustillo, Sonia, Morales Murillo, Ronald Octavio, Barrios Barrera, Clara, Vime-Jubany, Joan, Farré López, Núria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/57254
Acceso en línea:http://hdl.handle.net/10230/57254
http://dx.doi.org/10.3390/jcm12062339
Access Level:acceso abierto
Palabra clave:Advanced chronic kidney disease
Cardiorenal
Heart failure
Kidney dysfunction
Prognosis
Mortality
Descripción
Sumario:Despite the frequent coexistence of heart failure (HF) in patients with advanced chronic kidney disease (CKD), it has been understudied, and little is known about its prevalence and prognostic relevance. A retrospective study of 217 patients with advanced CKD (stages 4 and 5) who did not undergo renal replacement therapy (RRT). The patients were followed up for two years. The primary outcome was all-cause death or the need for RRT. Forty percent of patients had a history of HF. The mean age was 78.2 ± 8.8 years and the mean eGFR was 18.4 ± 5.5 mL/min/1.73 m2. The presence of previous HF identified a subgroup of high-risk patients with a high prevalence of cardiovascular comorbidities and was significantly associated with the composite endpoint of all-cause hospitalization or need for RRT (66.7% vs. 53.1%, HR 95% CI 1.62 (1.04–2.52), p = 0.034). No differences were found in the need for RRT (27.6% vs. 32.2%, p = 0.46). Nineteen patients without HF at baseline developed HF during the follow-up and all-cause death was numerically higher (36.8 vs. 19.8%, p = 0.1). Patients with advanced CKD have a high prevalence of HF. The presence of previous HF identified a high-risk population with a worse prognosis that required close follow-up.

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