Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)

To investigate whether physical activity (PA) is a protective factor for the incidence of Parkinson’s disease (PD) and parkinsonism after three years of follow-up. All participants of this study were obtained from the Neurological Disorders in Central Spain (NEDICES), a prospective population-based...

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Detalles Bibliográficos
Autores: Villarejo Galende, Alberto, Llamas-Velasco S,, Contador I,, Méndez-Guerrero A,, Romero Ferreiro C, ., Benito León, Julián, Bermejo Pareja, Félix
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/117648
Acceso en línea:https://hdl.handle.net/20.500.14352/117648
Access Level:acceso abierto
Palabra clave:616.858
Brain maintenance
Parkinsonism
Parkinson’s disease
Physical activity
Risk factor
Ciencias Biomédicas
32 Ciencias Médicas
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oai_identifier_str oai:docta.ucm.es:20.500.14352/117648
network_acronym_str ES
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repository_id_str
spelling Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)Villarejo Galende, AlbertoLlamas-Velasco S,Contador I,Méndez-Guerrero A,Romero Ferreiro C, .Benito León, JuliánBermejo Pareja, Félix616.858Brain maintenanceParkinsonismParkinson’s diseasePhysical activityRisk factorCiencias Biomédicas32 Ciencias MédicasTo investigate whether physical activity (PA) is a protective factor for the incidence of Parkinson’s disease (PD) and parkinsonism after three years of follow-up. All participants of this study were obtained from the Neurological Disorders in Central Spain (NEDICES), a prospective population-based cohort survey of older subjects (≥65 years) that comprised 5278 census-based participants at baseline (1994–1995). A modified version of Rosow-Breslau questionnaire was applied to categorize PA into active versus sedentary group. The final diagnosis of PD and parkinsonism was made by an expert neurologist. Cox regression models (CRM) adjusted for several covariates (sex, age, education, alcohol consumption, tobacco, stroke, hypertension and body mass index) were used to calculate the association between PA (active group vs. sedentary) and risk of PD and parkinsonism after three years. 22 incident PD and 25 incident parkinsonism cases were identified among 2943 participants with available PA information (57.1% female; mean age = 73.28 ± 6.24 years) after three years of follow-up. The CRM showed that the active group (vs. sedentary) showed a lower risk of parkinsonism (Hazard ratio (HR) = 0.18; 95% CI [0.07–0.51]; p = 0.0001). However, this effect was restricted to men (HR = 0.34; 95% CI [0.11–0.99], p < 0.05) for incident PD. PA may be a protective factor for incident parkinsonism, whereas this effect was only significant for men in the case of PD. The mechanisms implicated for brain maintenance in active individuals and the neurophysiological differences behind the role of sex on PD are discussed.ElsevierUniversidad Complutense de Madrid20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/117648reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1176482026-06-02T12:44:21Z
dc.title.none.fl_str_mv Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)
title Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)
spellingShingle Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)
Villarejo Galende, Alberto
616.858
Brain maintenance
Parkinsonism
Parkinson’s disease
Physical activity
Risk factor
Ciencias Biomédicas
32 Ciencias Médicas
title_short Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)
title_full Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)
title_fullStr Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)
title_full_unstemmed Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)
title_sort Physical activity and risk of Parkinson's disease and parkinsonism in a prospective population-based study (NEDICES)
dc.creator.none.fl_str_mv Villarejo Galende, Alberto
Llamas-Velasco S,
Contador I,
Méndez-Guerrero A,
Romero Ferreiro C, .
Benito León, Julián
Bermejo Pareja, Félix
author Villarejo Galende, Alberto
author_facet Villarejo Galende, Alberto
Llamas-Velasco S,
Contador I,
Méndez-Guerrero A,
Romero Ferreiro C, .
Benito León, Julián
Bermejo Pareja, Félix
author_role author
author2 Llamas-Velasco S,
Contador I,
Méndez-Guerrero A,
Romero Ferreiro C, .
Benito León, Julián
Bermejo Pareja, Félix
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.858
Brain maintenance
Parkinsonism
Parkinson’s disease
Physical activity
Risk factor
Ciencias Biomédicas
32 Ciencias Médicas
topic 616.858
Brain maintenance
Parkinsonism
Parkinson’s disease
Physical activity
Risk factor
Ciencias Biomédicas
32 Ciencias Médicas
description To investigate whether physical activity (PA) is a protective factor for the incidence of Parkinson’s disease (PD) and parkinsonism after three years of follow-up. All participants of this study were obtained from the Neurological Disorders in Central Spain (NEDICES), a prospective population-based cohort survey of older subjects (≥65 years) that comprised 5278 census-based participants at baseline (1994–1995). A modified version of Rosow-Breslau questionnaire was applied to categorize PA into active versus sedentary group. The final diagnosis of PD and parkinsonism was made by an expert neurologist. Cox regression models (CRM) adjusted for several covariates (sex, age, education, alcohol consumption, tobacco, stroke, hypertension and body mass index) were used to calculate the association between PA (active group vs. sedentary) and risk of PD and parkinsonism after three years. 22 incident PD and 25 incident parkinsonism cases were identified among 2943 participants with available PA information (57.1% female; mean age = 73.28 ± 6.24 years) after three years of follow-up. The CRM showed that the active group (vs. sedentary) showed a lower risk of parkinsonism (Hazard ratio (HR) = 0.18; 95% CI [0.07–0.51]; p = 0.0001). However, this effect was restricted to men (HR = 0.34; 95% CI [0.11–0.99], p < 0.05) for incident PD. PA may be a protective factor for incident parkinsonism, whereas this effect was only significant for men in the case of PD. The mechanisms implicated for brain maintenance in active individuals and the neurophysiological differences behind the role of sex on PD are discussed.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/117648
url https://hdl.handle.net/20.500.14352/117648
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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