New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes

Electrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and molecular weight by reaction of phosgene with...

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Autores: Díaz Andrade, Angélica María, Valle Mendoza, Luis Javier del|||0000-0001-9916-1741, Tugushi, David, Katsarava, Ramaz, Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/103928
Acceso en línea:https://hdl.handle.net/2117/103928
https://dx.doi.org/10.1016/j.msec.2014.10.055
Access Level:acceso abierto
Palabra clave:Polyesters
Polymers--Biodegradation
Poly(ester urea)
L-Leucine
Electrospinning
Scaffold
Enzymatic degradation
Biocompatibility
Biguanide
Drug release
alpha
omega-alkylene diesters
polyhexamethylene biguanide
polymer nanofibers
cellulose-acetate
chlorhexidine
polylactide
release
fibers
surfaces
degradation
Polímers -- Biocompatibilitat
Polièsters
Àrees temàtiques de la UPC::Enginyeria química
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spelling New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymesDíaz Andrade, Angélica MaríaValle Mendoza, Luis Javier del|||0000-0001-9916-1741Tugushi, DavidKatsarava, RamazPuiggalí Bellalta, Jordi|||0000-0002-0640-4474PolyestersPolymers--BiodegradationPoly(ester urea)L-LeucineElectrospinningScaffoldEnzymatic degradationBiocompatibilityBiguanideDrug releasealphaomega-alkylene diesterspolyhexamethylene biguanidepolymer nanofiberscellulose-acetatechlorhexidinepolylactidereleasefiberssurfacesdegradationPolímers -- BiocompatibilitatPolièstersÀrees temàtiques de la UPC::Enginyeria químicaElectrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and molecular weight by reaction of phosgene with a bis(alpha-aminoacy1)-alpha,omega-dioldiester monomer. The polymer having L-Ieucine, 1,6-hexanediol and carbonic acid units had a semicrystalline character and relatively high glass transition and melting temperatures. Furthermore it was highly soluble in most organic solvents, an interesting feature that facilitated the electrospinning process and the effective incorporation of drugs with bactericidal activity (e.g. biguanide derivatives such as clorhexidine and polyhexamethylenebiguanide) and enzymes (e.g. alpha-chymotrypsin) that accelerated the degradation process. Continuous micro/nanofibers were obtained under a wide range of processing conditions, being diameters of electrospun fibers dependent on the drug and solvent used.; Poly(ester urea) samples were degradable in media containing lipases and proteinases but the degradation rate was highly dependent on the surface area, being specifically greater for scaffolds with respect to films. The high hydrophobicity of new scaffolds had repercussions on enzymatic degradability since different weight loss rates were found depending on how samples were exposed to the medium (e.g. forced or non-forced immersion). New scaffolds were biocompatible, as demonstrated by adhesion and proliferation assays performed with fibroblast and epithelial cells. (C) 2014 Elsevier B.V. All rights reserved.Peer ReviewedElsevier20152015-01-0120172017-05-03journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/103928https://dx.doi.org/10.1016/j.msec.2014.10.055reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1039282026-05-27T15:37:01Z
dc.title.none.fl_str_mv New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes
title New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes
spellingShingle New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes
Díaz Andrade, Angélica María
Polyesters
Polymers--Biodegradation
Poly(ester urea)
L-Leucine
Electrospinning
Scaffold
Enzymatic degradation
Biocompatibility
Biguanide
Drug release
alpha
omega-alkylene diesters
polyhexamethylene biguanide
polymer nanofibers
cellulose-acetate
chlorhexidine
polylactide
release
fibers
surfaces
degradation
Polímers -- Biocompatibilitat
Polièsters
Àrees temàtiques de la UPC::Enginyeria química
title_short New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes
title_full New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes
title_fullStr New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes
title_full_unstemmed New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes
title_sort New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes
dc.creator.none.fl_str_mv Díaz Andrade, Angélica María
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Tugushi, David
Katsarava, Ramaz
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
author Díaz Andrade, Angélica María
author_facet Díaz Andrade, Angélica María
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Tugushi, David
Katsarava, Ramaz
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
author_role author
author2 Valle Mendoza, Luis Javier del|||0000-0001-9916-1741
Tugushi, David
Katsarava, Ramaz
Puiggalí Bellalta, Jordi|||0000-0002-0640-4474
author2_role author
author
author
author
dc.subject.none.fl_str_mv Polyesters
Polymers--Biodegradation
Poly(ester urea)
L-Leucine
Electrospinning
Scaffold
Enzymatic degradation
Biocompatibility
Biguanide
Drug release
alpha
omega-alkylene diesters
polyhexamethylene biguanide
polymer nanofibers
cellulose-acetate
chlorhexidine
polylactide
release
fibers
surfaces
degradation
Polímers -- Biocompatibilitat
Polièsters
Àrees temàtiques de la UPC::Enginyeria química
topic Polyesters
Polymers--Biodegradation
Poly(ester urea)
L-Leucine
Electrospinning
Scaffold
Enzymatic degradation
Biocompatibility
Biguanide
Drug release
alpha
omega-alkylene diesters
polyhexamethylene biguanide
polymer nanofibers
cellulose-acetate
chlorhexidine
polylactide
release
fibers
surfaces
degradation
Polímers -- Biocompatibilitat
Polièsters
Àrees temàtiques de la UPC::Enginyeria química
description Electrospun scaffolds from an amino acid containing poly(ester urea) (PEU) were developed as promising materials in the biomedical field and specifically in tissue engineering applications. The selected poly(ester urea) was obtained with a high yield and molecular weight by reaction of phosgene with a bis(alpha-aminoacy1)-alpha,omega-dioldiester monomer. The polymer having L-Ieucine, 1,6-hexanediol and carbonic acid units had a semicrystalline character and relatively high glass transition and melting temperatures. Furthermore it was highly soluble in most organic solvents, an interesting feature that facilitated the electrospinning process and the effective incorporation of drugs with bactericidal activity (e.g. biguanide derivatives such as clorhexidine and polyhexamethylenebiguanide) and enzymes (e.g. alpha-chymotrypsin) that accelerated the degradation process. Continuous micro/nanofibers were obtained under a wide range of processing conditions, being diameters of electrospun fibers dependent on the drug and solvent used.; Poly(ester urea) samples were degradable in media containing lipases and proteinases but the degradation rate was highly dependent on the surface area, being specifically greater for scaffolds with respect to films. The high hydrophobicity of new scaffolds had repercussions on enzymatic degradability since different weight loss rates were found depending on how samples were exposed to the medium (e.g. forced or non-forced immersion). New scaffolds were biocompatible, as demonstrated by adhesion and proliferation assays performed with fibroblast and epithelial cells. (C) 2014 Elsevier B.V. All rights reserved.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01
2017
2017-05-03
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/103928
https://dx.doi.org/10.1016/j.msec.2014.10.055
url https://hdl.handle.net/2117/103928
https://dx.doi.org/10.1016/j.msec.2014.10.055
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411847469268992
score 15,300724

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