Microfibres of conducting polythiophene and biodegradable poly(ester urea) for scaffolds
Hybrid scaffolds constituted of a mixture of conducting and biodegradable polymers are obtained by the electrospinning technique. Specifically, poly(3-thiophene methyl acetate) (P3TMA) and a copolymer derived from L-leucine, which bears ester, urea and amide groups (PEU-co-PEA), have been employed....
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/28354 |
| Acceso en línea: | https://hdl.handle.net/2117/28354 https://dx.doi.org/10.1039/c4py01243g |
| Access Level: | acceso abierto |
| Palabra clave: | Polymers--Biodegradation TISSUE ENGINEERING APPLICATIONS BIOMEDICAL APPLICATIONS ALPHA OMEGA-ALKYLENE DIESTERS DICARBOXYLIC-ACIDS POLYMERS NANOFIBERS NANOMEMBRANES AMIDE)S POLYPYRROLE DEGRADATION Polímers -- Biodegradació Àrees temàtiques de la UPC::Enginyeria química |
| Sumario: | Hybrid scaffolds constituted of a mixture of conducting and biodegradable polymers are obtained by the electrospinning technique. Specifically, poly(3-thiophene methyl acetate) (P3TMA) and a copolymer derived from L-leucine, which bears ester, urea and amide groups (PEU-co-PEA), have been employed. Both polymers were selected because of their intrinsic properties and their high solubility in organic solvents. The biodegradable polymer renders continuous and homogeneous microfibers under most of the electrospinning conditions tested, appearing to be an ideal carrier for the polythiophene derivative. A spontaneous phase separation has been observed for concentrated solutions of PEU-co-PEA and P3TMA in chloroform-methanol mixtures. An enriched dense phase results on the conducting polymer and can be successfully electrospun, giving rise to scaffolds with up to 90 wt% of P3TMA. Morphological observations have indicated that continuous and regular microfibers are attained despite the high conducting polymer content. P3TMA presents a high doping level and leads to stable electrospun scaffolds by the simple addition of a low percentage of a high molecular weight carrier. The resulting scaffolds are practically amorphous and thermally stable, also presenting a pronounced electrochemical response and being electrochemically active. Thus, the formation of polarons and bipolarons at specific positions, the ability to exchange charge reversibly and the electrical stability of hybrid PEU-co-PEA/P3TMA electrospun scaffolds and P3TMA alone are practically the same. biodegradability for their use as scaffolds. Different strategies |
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