Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes

Functional connectivity studies to detect neurophysiological correlates of amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer’s disease, have generated contradictory results in terms of compensation and deterioration, as most of the studies did not distinguish between the diff...

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Detalles Bibliográficos
Autores: Varela-López, Benxamín, Zurrón Ocio, Montserrat, Lindín Novo, Mónica, Díaz Fernández, Fernando, Galdo Álvarez, Santiago
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/38994
Acceso en línea:https://hdl.handle.net/10347/38994
Access Level:acceso abierto
Palabra clave:Resting-state functional magnetic resonance imaging
Amnestic MCI
Amnestic MCI subtypes
Default mode network
Fronto-parietal control network
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spelling Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypesVarela-López, BenxamínZurrón Ocio, MontserratLindín Novo, MónicaDíaz Fernández, FernandoGaldo Álvarez, SantiagoResting-state functional magnetic resonance imagingAmnestic MCIAmnestic MCI subtypesDefault mode networkFronto-parietal control networkFunctional connectivity studies to detect neurophysiological correlates of amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer’s disease, have generated contradictory results in terms of compensation and deterioration, as most of the studies did not distinguish between the different aMCI subtypes: single-domain aMCI (sd-aMCI) and multiple-domain aMCI (md-aMCI). The present study aimed to characterize the neurophysiological correlates of aMCI subtypes by using resting-state functional magnetic resonance imaging. The study included sd-aMCI (n = 29), md-aMCI (n = 26), and control (n = 30) participants. The data were subjected to independent component analysis (ICA) to explore the default mode network (DMN) and the fronto-parietal control network (FPCN). Additionally, seed-based and moderation analyses were conducted to investigate the connectivity of the medial temporal lobe and functional networks. aMCI subtypes presented differences in functional connectivity relative to the control group: sd-aMCI participants displayed increased FPCN connectivity and reduced connectivity between the posterior parahippocampal gyrus (PHG) and medial structures; md-aMCI participants exhibited lower FPCN connectivity, higher anterior PHG connectivity with frontal structures and lower posterior PHG connectivity with central-parietal and temporo-occipital areas. Additionally, md-aMCI participants showed higher posterior PHG connectivity with structures of the DMN than both control and sd-aMCI participants, potentially indicating more severe cognitive deficits. The results showed gradual and qualitative neurofunctional differences between the aMCI subgroups, suggesting the existence of compensatory (sd-aMCI) and deterioration (mdaMCI) mechanisms in functional networks, mainly originated in the DMN. The findings support consideration of the subgroups as different stages of MCI within the Alzheimer disease continuum.SpringerUniversidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e PsicobioloxíaUniversidade de Santiago de Compostela. Instituto de Psicoloxía (IPsiUS)20242024-10-0520242024-10-05journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/38994reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/389942026-06-15T12:47:27Z
dc.title.none.fl_str_mv Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
title Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
spellingShingle Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
Varela-López, Benxamín
Resting-state functional magnetic resonance imaging
Amnestic MCI
Amnestic MCI subtypes
Default mode network
Fronto-parietal control network
title_short Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
title_full Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
title_fullStr Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
title_full_unstemmed Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
title_sort Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes
dc.creator.none.fl_str_mv Varela-López, Benxamín
Zurrón Ocio, Montserrat
Lindín Novo, Mónica
Díaz Fernández, Fernando
Galdo Álvarez, Santiago
author Varela-López, Benxamín
author_facet Varela-López, Benxamín
Zurrón Ocio, Montserrat
Lindín Novo, Mónica
Díaz Fernández, Fernando
Galdo Álvarez, Santiago
author_role author
author2 Zurrón Ocio, Montserrat
Lindín Novo, Mónica
Díaz Fernández, Fernando
Galdo Álvarez, Santiago
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Psicoloxía Clínica e Psicobioloxía
Universidade de Santiago de Compostela. Instituto de Psicoloxía (IPsiUS)
dc.subject.none.fl_str_mv Resting-state functional magnetic resonance imaging
Amnestic MCI
Amnestic MCI subtypes
Default mode network
Fronto-parietal control network
topic Resting-state functional magnetic resonance imaging
Amnestic MCI
Amnestic MCI subtypes
Default mode network
Fronto-parietal control network
description Functional connectivity studies to detect neurophysiological correlates of amnestic mild cognitive impairment (aMCI), a prodromal stage of Alzheimer’s disease, have generated contradictory results in terms of compensation and deterioration, as most of the studies did not distinguish between the different aMCI subtypes: single-domain aMCI (sd-aMCI) and multiple-domain aMCI (md-aMCI). The present study aimed to characterize the neurophysiological correlates of aMCI subtypes by using resting-state functional magnetic resonance imaging. The study included sd-aMCI (n = 29), md-aMCI (n = 26), and control (n = 30) participants. The data were subjected to independent component analysis (ICA) to explore the default mode network (DMN) and the fronto-parietal control network (FPCN). Additionally, seed-based and moderation analyses were conducted to investigate the connectivity of the medial temporal lobe and functional networks. aMCI subtypes presented differences in functional connectivity relative to the control group: sd-aMCI participants displayed increased FPCN connectivity and reduced connectivity between the posterior parahippocampal gyrus (PHG) and medial structures; md-aMCI participants exhibited lower FPCN connectivity, higher anterior PHG connectivity with frontal structures and lower posterior PHG connectivity with central-parietal and temporo-occipital areas. Additionally, md-aMCI participants showed higher posterior PHG connectivity with structures of the DMN than both control and sd-aMCI participants, potentially indicating more severe cognitive deficits. The results showed gradual and qualitative neurofunctional differences between the aMCI subgroups, suggesting the existence of compensatory (sd-aMCI) and deterioration (mdaMCI) mechanisms in functional networks, mainly originated in the DMN. The findings support consideration of the subgroups as different stages of MCI within the Alzheimer disease continuum.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-10-05
2024
2024-10-05
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/38994
url https://hdl.handle.net/10347/38994
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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