Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype

The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8.5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. The aim of this study was to find the optimized cognitive composites (CCs...

Descripción completa

Detalles Bibliográficos
Autores: Espinosa, Ana|||0000-0001-7399-3267, Alegret, Montserrat|||0000-0002-8164-9500, Pesini, Pedro|||0000-0002-0656-2384, Valero Ventura, Sergi, Lafuente, Asunción, Buendía, Mar, San José, Itziar, Ibarria, Marta, Tejero, Miguel Ángel, Giménez Ruiz, Joan, Ruiz, Susana, Hernández, Isabel|||0000-0001-8119-393X, Pujadas, Francesc|||0000-0003-3569-2601, Martínez Lage, Pablo, Munuera, Josep|||0000-0001-5154-1796, Arbizu, Javier|||0000-0002-8370-5510, Tárraga, Lluís|||0000-0002-8423-946X, Hendrix, Suzanne B., Ruiz Laza, Agustín|||0000-0003-2633-2495, Becker, James T.|||0000-0003-4425-4726, Landau, Susan M., Sotolongo Grau, Oscar|||0000-0002-9679-0670, Sarasa, Manuel, Boada, Mercè|||0000-0003-2617-3009
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:186174
Acceso en línea:https://ddd.uab.cat/record/186174
https://dx.doi.org/urn:doi:10.3233/JAD-161223
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Amnestic mild cognitive impairment
Amyloid
Cognition
Hippocampus
Magnetic resonance imaging
Memory
Positron emission tomography
Descripción
Sumario:The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8.5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. The aim of this study was to find the optimized cognitive composites (CCs) domain scores most related to neuroimaging biomarkers within Pr-aMCI-storage subtype patients. The Fundació ACE (ACE) study with 20 Pr-aMCI-storage subtype subjects (MCI) were analyzed. All subjects underwent a neuropsychological assessment, a structural MRI, FDG-PET, and PIB-PET. The adjusted hippocampal volume (aHV) on MRI, the standard uptake value ratio (SUVR) on FDG-PET and PIB-PET SUVR measures were analyzed. The construction of the CCs domain scores, and the aHV on MRI and FDG-PET SUVR measures, were replicated in the parental AB255 study database (n = 133 MCI). Partial correlations adjusted by age, gender, and education were calculated with the associated p -value among every CC domain score and the neuroimaging biomarkers. The results were replicated in the "MCI due to AD" with memory storage impairments from ADNI. Delayed Recall CC domain score was significantly correlated with PIB-PET SUVR (β= -0.61, p = 0.003) in the ACE study and also with aHV on MRI (β= 0.27, p = 0.01) and FDG-PET SUVR (β= 0.27, p = 0.01) in the AB255 study. After a median survival time of 20.6 months, 85% from the ACE MCI converted to AD. The replication of our results in the ADNI dataset also confirmed our findings. Delayed Recall is the CC domain score best correlated with neuroimaging biomarkers associated with prodromal AD diagnosis.

Similares en LA Referencia