Nanoparticles in Endodontics Disinfection: State of the Art

Endodontic-related diseases constitute the fourth most expensive pathologies in industrialized countries. Specifically, endodontics is the part of dentistry focused on treating disorders of the dental pulp and its consequences. In order to treat these problems, especially endodontic infections, dent...

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Autores: Roig-Soriano, Xavier, Souto, Eliana B., Elmsmari, Firas, Garcia, Maria Luisa, Espina, Marta, Duran-Sindreu, Fernando, Sánchez-López, Elena, González Sánchez, Jose Antonio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/279616
Acceso en línea:http://hdl.handle.net/10261/279616
https://api.elsevier.com/content/abstract/scopus_id/85137295267
Access Level:acceso abierto
Palabra clave:Nanoparticles
PLGA
Dentistry
Endodontics
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spelling Nanoparticles in Endodontics Disinfection: State of the ArtRoig-Soriano, XavierSouto, Eliana B.Elmsmari, FirasGarcia, Maria LuisaEspina, MartaDuran-Sindreu, FernandoSánchez-López, ElenaGonzález Sánchez, Jose AntonioNanoparticlesPLGADentistryEndodonticsEndodontic-related diseases constitute the fourth most expensive pathologies in industrialized countries. Specifically, endodontics is the part of dentistry focused on treating disorders of the dental pulp and its consequences. In order to treat these problems, especially endodontic infections, dental barriers and complex root canal anatomy should be overcome. This constitutes an unmet medical need since the rate of successful disinfection with the currently marketed drugs is around 85%. Therefore, nanoparticles constitute a suitable alternative in order to deliver active compounds effectively to the target site, increasing their therapeutic efficacy. Therefore, in the present review, an overview of dental anatomy and the barriers that should be overcome for effective disinfection will be summarized. In addition, the versatility of nanoparticles for drug delivery and their specific uses in dentistry are comprehensively discussed. Finally, the latest findings, potential applications and state of the art nanoparticles with special emphasis on biodegradable nanoparticles used for endodontic disinfection are also reviewed.This work was funded by the F2I-PdC_2021-002 project (FBG6000324), and also supported by the Grants for the Requalification of the Spanish University System, granted to E.S.L.Peer reviewedMultidisciplinary Digital Publishing Institute0000-0002-9737-60170000-0003-1269-38470000-0003-2571-108X0000-0001-8684-835XConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/279616https://api.elsevier.com/content/abstract/scopus_id/85137295267reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésPharmaceuticshttps://doi.org/10.3390/pharmaceutics14071519Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2796162026-05-22T06:33:51Z
dc.title.none.fl_str_mv Nanoparticles in Endodontics Disinfection: State of the Art
title Nanoparticles in Endodontics Disinfection: State of the Art
spellingShingle Nanoparticles in Endodontics Disinfection: State of the Art
Roig-Soriano, Xavier
Nanoparticles
PLGA
Dentistry
Endodontics
title_short Nanoparticles in Endodontics Disinfection: State of the Art
title_full Nanoparticles in Endodontics Disinfection: State of the Art
title_fullStr Nanoparticles in Endodontics Disinfection: State of the Art
title_full_unstemmed Nanoparticles in Endodontics Disinfection: State of the Art
title_sort Nanoparticles in Endodontics Disinfection: State of the Art
dc.creator.none.fl_str_mv Roig-Soriano, Xavier
Souto, Eliana B.
Elmsmari, Firas
Garcia, Maria Luisa
Espina, Marta
Duran-Sindreu, Fernando
Sánchez-López, Elena
González Sánchez, Jose Antonio
author Roig-Soriano, Xavier
author_facet Roig-Soriano, Xavier
Souto, Eliana B.
Elmsmari, Firas
Garcia, Maria Luisa
Espina, Marta
Duran-Sindreu, Fernando
Sánchez-López, Elena
González Sánchez, Jose Antonio
author_role author
author2 Souto, Eliana B.
Elmsmari, Firas
Garcia, Maria Luisa
Espina, Marta
Duran-Sindreu, Fernando
Sánchez-López, Elena
González Sánchez, Jose Antonio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv 0000-0002-9737-6017
0000-0003-1269-3847
0000-0003-2571-108X
0000-0001-8684-835X
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Nanoparticles
PLGA
Dentistry
Endodontics
topic Nanoparticles
PLGA
Dentistry
Endodontics
description Endodontic-related diseases constitute the fourth most expensive pathologies in industrialized countries. Specifically, endodontics is the part of dentistry focused on treating disorders of the dental pulp and its consequences. In order to treat these problems, especially endodontic infections, dental barriers and complex root canal anatomy should be overcome. This constitutes an unmet medical need since the rate of successful disinfection with the currently marketed drugs is around 85%. Therefore, nanoparticles constitute a suitable alternative in order to deliver active compounds effectively to the target site, increasing their therapeutic efficacy. Therefore, in the present review, an overview of dental anatomy and the barriers that should be overcome for effective disinfection will be summarized. In addition, the versatility of nanoparticles for drug delivery and their specific uses in dentistry are comprehensively discussed. Finally, the latest findings, potential applications and state of the art nanoparticles with special emphasis on biodegradable nanoparticles used for endodontic disinfection are also reviewed.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/279616
https://api.elsevier.com/content/abstract/scopus_id/85137295267
url http://hdl.handle.net/10261/279616
https://api.elsevier.com/content/abstract/scopus_id/85137295267
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Pharmaceutics
https://doi.org/10.3390/pharmaceutics14071519
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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