Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy

Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in aging. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated aging in adipose tissue. We compared systemic and adipose tiss...

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Detalles Bibliográficos
Autores: Domingo, Pere (Domingo Pedrol), Giralt i Oms, Marta, Gavaldà i Navarro, Aleix, Blasco Roset, Albert, Delgado Anglés, Alejandro, Gallego Escuredo, José Miguel, Gutiérrez, Maria del Mar, Mateo, Maria Gracia, Cereijo Téllez, Rubén, Domingo i Pedrol, Joan Carles, Villarroya i Gombau, Francesc, Villarroya i Terrade, Joan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/219067
Acceso en línea:https://hdl.handle.net/2445/219067
Access Level:acceso abierto
Palabra clave:Síndrome de lipodistròfia associada a VIH
Inflamació
Autofàgia
Teixit adipós
HIV-associated lipodystrophy syndrome
Inflammation
Autophagy
Adipose tissues
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spelling Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophyDomingo, Pere (Domingo Pedrol)Giralt i Oms, MartaGavaldà i Navarro, AleixBlasco Roset, AlbertDelgado Anglés, AlejandroGallego Escuredo, José MiguelGutiérrez, Maria del MarMateo, Maria GraciaCereijo Téllez, RubénDomingo i Pedrol, Joan CarlesVillarroya i Gombau, FrancescVillarroya i Terrade, JoanSíndrome de lipodistròfia associada a VIHInflamacióAutofàgiaTeixit adipósHIV-associated lipodystrophy syndromeInflammationAutophagyAdipose tissuesLipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in aging. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated aging in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 year-old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that aging of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH.Taylor & Francis2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/219067Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1080/21623945.2022.2042962Adipocyte, 2022, vol. 11, num.1, p. 143-152https://doi.org/10.1080/21623945.2022.2042962cc-by (c) Domingo, P. et al., 2022http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2190672026-05-27T06:46:51Z
dc.title.none.fl_str_mv Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
title Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
spellingShingle Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
Domingo, Pere (Domingo Pedrol)
Síndrome de lipodistròfia associada a VIH
Inflamació
Autofàgia
Teixit adipós
HIV-associated lipodystrophy syndrome
Inflammation
Autophagy
Adipose tissues
title_short Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
title_full Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
title_fullStr Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
title_full_unstemmed Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
title_sort Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
dc.creator.none.fl_str_mv Domingo, Pere (Domingo Pedrol)
Giralt i Oms, Marta
Gavaldà i Navarro, Aleix
Blasco Roset, Albert
Delgado Anglés, Alejandro
Gallego Escuredo, José Miguel
Gutiérrez, Maria del Mar
Mateo, Maria Gracia
Cereijo Téllez, Rubén
Domingo i Pedrol, Joan Carles
Villarroya i Gombau, Francesc
Villarroya i Terrade, Joan
author Domingo, Pere (Domingo Pedrol)
author_facet Domingo, Pere (Domingo Pedrol)
Giralt i Oms, Marta
Gavaldà i Navarro, Aleix
Blasco Roset, Albert
Delgado Anglés, Alejandro
Gallego Escuredo, José Miguel
Gutiérrez, Maria del Mar
Mateo, Maria Gracia
Cereijo Téllez, Rubén
Domingo i Pedrol, Joan Carles
Villarroya i Gombau, Francesc
Villarroya i Terrade, Joan
author_role author
author2 Giralt i Oms, Marta
Gavaldà i Navarro, Aleix
Blasco Roset, Albert
Delgado Anglés, Alejandro
Gallego Escuredo, José Miguel
Gutiérrez, Maria del Mar
Mateo, Maria Gracia
Cereijo Téllez, Rubén
Domingo i Pedrol, Joan Carles
Villarroya i Gombau, Francesc
Villarroya i Terrade, Joan
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Síndrome de lipodistròfia associada a VIH
Inflamació
Autofàgia
Teixit adipós
HIV-associated lipodystrophy syndrome
Inflammation
Autophagy
Adipose tissues
topic Síndrome de lipodistròfia associada a VIH
Inflamació
Autofàgia
Teixit adipós
HIV-associated lipodystrophy syndrome
Inflammation
Autophagy
Adipose tissues
description Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in aging. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated aging in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 year-old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that aging of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219067
url https://hdl.handle.net/2445/219067
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1080/21623945.2022.2042962
Adipocyte, 2022, vol. 11, num.1, p. 143-152
https://doi.org/10.1080/21623945.2022.2042962
dc.rights.none.fl_str_mv cc-by (c) Domingo, P. et al., 2022
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Domingo, P. et al., 2022
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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