Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy
Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in aging. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated aging in adipose tissue. We compared systemic and adipose tiss...
| Autores: | , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/219067 |
| Acceso en línea: | https://hdl.handle.net/2445/219067 |
| Access Level: | acceso abierto |
| Palabra clave: | Síndrome de lipodistròfia associada a VIH Inflamació Autofàgia Teixit adipós HIV-associated lipodystrophy syndrome Inflammation Autophagy Adipose tissues |
| Sumario: | Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in aging. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated aging in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 year-old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that aging of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH. |
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