Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients
The question whether information extracted from the electroencephalogram ~EEG! of epilepsy patients can be used for the prediction of seizures has recently attracted much attention. Several studies have reported evidence for the existence of a preseizure state that can be detected using different me...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2003 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/43633 |
| Acceso en línea: | http://hdl.handle.net/10230/43633 http://dx.doi.org/10.1103/PhysRevE.67.021912 |
| Access Level: | acceso abierto |
| Palabra clave: | Nonlinear signal analysis Synchronization Electroencephalographic recordings Epilepsy Seizure prediction |
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Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patientsMormann, FlorianAndrzejak, Ralph GregorKreuz, ThomasRieke, ChristophDavid, PeterElger, Christian E.Lehnertz, KlausNonlinear signal analysisSynchronizationElectroencephalographic recordingsEpilepsySeizure predictionThe question whether information extracted from the electroencephalogram ~EEG! of epilepsy patients can be used for the prediction of seizures has recently attracted much attention. Several studies have reported evidence for the existence of a preseizure state that can be detected using different measures derived from the theory of dynamical systems. Most of these studies, however, have neglected to sufficiently investigate the specificity of the observed effects or suffer from other methodological shortcomings. In this paper we present an automated technique for the detection of a preseizure state from EEG recordings using two different measures for synchronization between recording sites, namely, the mean phase coherence as a measure for phase synchronization and the maximum linear cross correlation as a measure for lag synchronization. Based on the observation of characteristic drops in synchronization prior to seizure onset, we used this phenomenon for the characterization of a preseizure state and its distinction from the remaining seizure-free interval. After optimizing our technique on a group of 10 patients with temporal lobe epilepsy we obtained a successful detection of a preseizure state prior to 12 out of 14 analyzed seizures for both measures at a very high specificity as tested on recordings from the seizure-free interval. After checking for in-sample overtraining via cross validation, we applied a surrogate test to validate the observed predictability. Based on our results, we discuss the differences of the two synchronization measures in terms of the dynamics underlying seizure generation in focal epilepsies.This work was supported by the Deutsche Forschungsgemeinschaft.American Physical Society202020202003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/43633http://dx.doi.org/10.1103/PhysRevE.67.021912reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPhysical Review E. 2003;67:021912info:eu-repo/semantics/openAccessoai:recercat.cat:10230/436332026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients |
| title |
Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients |
| spellingShingle |
Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients Mormann, Florian Nonlinear signal analysis Synchronization Electroencephalographic recordings Epilepsy Seizure prediction |
| title_short |
Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients |
| title_full |
Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients |
| title_fullStr |
Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients |
| title_full_unstemmed |
Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients |
| title_sort |
Automated detection of a preseizure state based on a decrease in synchronization in intracranial electroencephalogram recordings from epilepsy patients |
| dc.creator.none.fl_str_mv |
Mormann, Florian Andrzejak, Ralph Gregor Kreuz, Thomas Rieke, Christoph David, Peter Elger, Christian E. Lehnertz, Klaus |
| author |
Mormann, Florian |
| author_facet |
Mormann, Florian Andrzejak, Ralph Gregor Kreuz, Thomas Rieke, Christoph David, Peter Elger, Christian E. Lehnertz, Klaus |
| author_role |
author |
| author2 |
Andrzejak, Ralph Gregor Kreuz, Thomas Rieke, Christoph David, Peter Elger, Christian E. Lehnertz, Klaus |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Nonlinear signal analysis Synchronization Electroencephalographic recordings Epilepsy Seizure prediction |
| topic |
Nonlinear signal analysis Synchronization Electroencephalographic recordings Epilepsy Seizure prediction |
| description |
The question whether information extracted from the electroencephalogram ~EEG! of epilepsy patients can be used for the prediction of seizures has recently attracted much attention. Several studies have reported evidence for the existence of a preseizure state that can be detected using different measures derived from the theory of dynamical systems. Most of these studies, however, have neglected to sufficiently investigate the specificity of the observed effects or suffer from other methodological shortcomings. In this paper we present an automated technique for the detection of a preseizure state from EEG recordings using two different measures for synchronization between recording sites, namely, the mean phase coherence as a measure for phase synchronization and the maximum linear cross correlation as a measure for lag synchronization. Based on the observation of characteristic drops in synchronization prior to seizure onset, we used this phenomenon for the characterization of a preseizure state and its distinction from the remaining seizure-free interval. After optimizing our technique on a group of 10 patients with temporal lobe epilepsy we obtained a successful detection of a preseizure state prior to 12 out of 14 analyzed seizures for both measures at a very high specificity as tested on recordings from the seizure-free interval. After checking for in-sample overtraining via cross validation, we applied a surrogate test to validate the observed predictability. Based on our results, we discuss the differences of the two synchronization measures in terms of the dynamics underlying seizure generation in focal epilepsies. |
| publishDate |
2003 |
| dc.date.none.fl_str_mv |
2003 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/43633 http://dx.doi.org/10.1103/PhysRevE.67.021912 |
| url |
http://hdl.handle.net/10230/43633 http://dx.doi.org/10.1103/PhysRevE.67.021912 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Physical Review E. 2003;67:021912 |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
American Physical Society |
| publisher.none.fl_str_mv |
American Physical Society |
| dc.source.none.fl_str_mv |
reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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