Testing the null hypothesis of the nonexistence of a preseizure state

A rapidly growing number of studies deals with the prediction of epileptic seizures. For this purpose, various techniques derived from linear and nonlinear time series analysis have been applied to the electroencephalogram of epilepsy patients. In none of these works, however, the performance of the...

Descripción completa

Detalles Bibliográficos
Autores: Andrzejak, Ralph Gregor, Mormann, Florian, Kreuz, Thomas, Rieke, Christoph, Kraskov, Alexander, Elger, Christian E., Lehnertz, Klaus
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2003
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/43635
Acceso en línea:http://hdl.handle.net/10230/43635
http://dx.doi.org/10.1103/PhysRevE.67.010901
Access Level:acceso abierto
Palabra clave:Nonlinear signal analysis
Electroencephalographic recordings
Epilepsy
Seizure prediction
Descripción
Sumario:A rapidly growing number of studies deals with the prediction of epileptic seizures. For this purpose, various techniques derived from linear and nonlinear time series analysis have been applied to the electroencephalogram of epilepsy patients. In none of these works, however, the performance of the seizure prediction statistics is tested against a null hypothesis, an otherwise ubiquitous concept in science. In consequence, the evaluation of the reported performance values is problematic. Here, we propose the technique of seizure time surrogates based on a Monte Carlo simulation to remedy this deficit.