Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions
Background Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied. Methods One-hundred sixteen individuals with FEP (mean age = 23.8 ± 6.9 yea...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/222897 |
| Acceso en línea: | https://hdl.handle.net/2445/222897 |
| Access Level: | acceso abierto |
| Palabra clave: | Psicosi en els infants Neuropsiquiatria pediàtrica Psychoses in children Pediatric neuropsychiatry |
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Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regionsFares Otero, Natalia ElenaVerdolini, NormaMelero, HelenaAndrés Camazón, PabloVilajosana, EnricCavone, VitoGarcía Bueno, BorjaRapado Castro, MartaIzquierdo, AnaMartín Hernández, DavidMola Cárdenes, PabloLeal Leturia, ItziarDompablo Tobar, MónicaOrtiz Tallo, AnaMartínez Gras, IsabelMuñoz Sanjose, AinoaLoeck de Lapuerta, CarmenRodriguez Jimenez, RobertoDíaz-Marsá, MarinaBravo Ortiz, María FeIbáñez Cuadrado, ÁngelaBaca García, EnriqueVieta i Pascual, Eduard, 1963-Ayuso Mateos, José LuisMalpica, NorbertoArango López, CelsoDíaz Caneja, Covadonga M.Radua, JoaquimPsicosi en els infantsNeuropsiquiatria pediàtricaPsychoses in childrenPediatric neuropsychiatryBackground Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied. Methods One-hundred sixteen individuals with FEP (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) and 98 healthy controls (HCs) (mean age = 24.4 ± 6.2 years, 43% females) reported the presence/absence of CA <17 years using an adapted version of the Childhood Experience of Care and Abuse (CECA.Q) and the Retrospective Bullying Questionnaire (RBQ) and underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used to assess associations between brain maps of CA and FEP effects. General linear models (GLMs) were performed to assess the interaction effects of CA and FEP on CT. Results Eighty-three individuals with FEP and 83 HCs reported exposure to at least one CA. CT alterations in FEP were similar to those found in participants exposed to separation from parents, bullying, parental discord, household poverty, and sexual abuse (r = 0.50 to 0.25). Exposure to neglect (β = −0.24, 95% CI [−0.37 to −0.12], p = 0.016) and overall maltreatment (β = −0.13, 95% CI [−0.20 to −0.06], p = 0.043) were associated with cortical thinning in the right medial orbitofrontal region. Conclusions Cortical alterations in individuals with FEP are similar to those observed in the context of socio-environmental adversity. Neglect and maltreatment may contribute to CT reductions in FEP. Our findings provide new insights into the specific neurobiological effects of CA in early psychosis.Cambridge University Press (CUP)2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/222897Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1017/S0033291724002393Psychological Medicine, 2024, vol. 54, num.16, p. 4561-4574https://doi.org/10.1017/S0033291724002393cc-by (c) Fares Otero, Natalia Elena et al., 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2228972026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions |
| title |
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions |
| spellingShingle |
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions Fares Otero, Natalia Elena Psicosi en els infants Neuropsiquiatria pediàtrica Psychoses in children Pediatric neuropsychiatry |
| title_short |
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions |
| title_full |
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions |
| title_fullStr |
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions |
| title_full_unstemmed |
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions |
| title_sort |
Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions |
| dc.creator.none.fl_str_mv |
Fares Otero, Natalia Elena Verdolini, Norma Melero, Helena Andrés Camazón, Pablo Vilajosana, Enric Cavone, Vito García Bueno, Borja Rapado Castro, Marta Izquierdo, Ana Martín Hernández, David Mola Cárdenes, Pablo Leal Leturia, Itziar Dompablo Tobar, Mónica Ortiz Tallo, Ana Martínez Gras, Isabel Muñoz Sanjose, Ainoa Loeck de Lapuerta, Carmen Rodriguez Jimenez, Roberto Díaz-Marsá, Marina Bravo Ortiz, María Fe Ibáñez Cuadrado, Ángela Baca García, Enrique Vieta i Pascual, Eduard, 1963- Ayuso Mateos, José Luis Malpica, Norberto Arango López, Celso Díaz Caneja, Covadonga M. Radua, Joaquim |
| author |
Fares Otero, Natalia Elena |
| author_facet |
Fares Otero, Natalia Elena Verdolini, Norma Melero, Helena Andrés Camazón, Pablo Vilajosana, Enric Cavone, Vito García Bueno, Borja Rapado Castro, Marta Izquierdo, Ana Martín Hernández, David Mola Cárdenes, Pablo Leal Leturia, Itziar Dompablo Tobar, Mónica Ortiz Tallo, Ana Martínez Gras, Isabel Muñoz Sanjose, Ainoa Loeck de Lapuerta, Carmen Rodriguez Jimenez, Roberto Díaz-Marsá, Marina Bravo Ortiz, María Fe Ibáñez Cuadrado, Ángela Baca García, Enrique Vieta i Pascual, Eduard, 1963- Ayuso Mateos, José Luis Malpica, Norberto Arango López, Celso Díaz Caneja, Covadonga M. Radua, Joaquim |
| author_role |
author |
| author2 |
Verdolini, Norma Melero, Helena Andrés Camazón, Pablo Vilajosana, Enric Cavone, Vito García Bueno, Borja Rapado Castro, Marta Izquierdo, Ana Martín Hernández, David Mola Cárdenes, Pablo Leal Leturia, Itziar Dompablo Tobar, Mónica Ortiz Tallo, Ana Martínez Gras, Isabel Muñoz Sanjose, Ainoa Loeck de Lapuerta, Carmen Rodriguez Jimenez, Roberto Díaz-Marsá, Marina Bravo Ortiz, María Fe Ibáñez Cuadrado, Ángela Baca García, Enrique Vieta i Pascual, Eduard, 1963- Ayuso Mateos, José Luis Malpica, Norberto Arango López, Celso Díaz Caneja, Covadonga M. Radua, Joaquim |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Psicosi en els infants Neuropsiquiatria pediàtrica Psychoses in children Pediatric neuropsychiatry |
| topic |
Psicosi en els infants Neuropsiquiatria pediàtrica Psychoses in children Pediatric neuropsychiatry |
| description |
Background Both childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied. Methods One-hundred sixteen individuals with FEP (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) and 98 healthy controls (HCs) (mean age = 24.4 ± 6.2 years, 43% females) reported the presence/absence of CA <17 years using an adapted version of the Childhood Experience of Care and Abuse (CECA.Q) and the Retrospective Bullying Questionnaire (RBQ) and underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used to assess associations between brain maps of CA and FEP effects. General linear models (GLMs) were performed to assess the interaction effects of CA and FEP on CT. Results Eighty-three individuals with FEP and 83 HCs reported exposure to at least one CA. CT alterations in FEP were similar to those found in participants exposed to separation from parents, bullying, parental discord, household poverty, and sexual abuse (r = 0.50 to 0.25). Exposure to neglect (β = −0.24, 95% CI [−0.37 to −0.12], p = 0.016) and overall maltreatment (β = −0.13, 95% CI [−0.20 to −0.06], p = 0.043) were associated with cortical thinning in the right medial orbitofrontal region. Conclusions Cortical alterations in individuals with FEP are similar to those observed in the context of socio-environmental adversity. Neglect and maltreatment may contribute to CT reductions in FEP. Our findings provide new insights into the specific neurobiological effects of CA in early psychosis. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2445/222897 |
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https://hdl.handle.net/2445/222897 |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1017/S0033291724002393 Psychological Medicine, 2024, vol. 54, num.16, p. 4561-4574 https://doi.org/10.1017/S0033291724002393 |
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cc-by (c) Fares Otero, Natalia Elena et al., 2024 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
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cc-by (c) Fares Otero, Natalia Elena et al., 2024 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Cambridge University Press (CUP) |
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Cambridge University Press (CUP) |
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Articles publicats en revistes (Medicina) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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