Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia

Animals acquire behaviors through instrumental conditioning. Brain-machine interfaces have used instrumental conditioning to reinforce patterns of neural activity directly, especially in frontal and motor cortices, which are a rich source of signals for voluntary action. However, evidence suggests t...

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Detalles Bibliográficos
Autores: Neely, Ryan M., Koralek, Aaron C., Athalye, Vivek R., Costa, Rui M., Carmena Ramón, José Miguel
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/7045
Acceso en línea:https://hdl.handle.net/20.500.12466/7045
Access Level:acceso abierto
Palabra clave:Brain-machine interface
Instrumental conditioning
Learning
Optogenetics
Striatum
Visual cortex
32 Ciencias Médicas
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spelling Volitional Modulation of Primary Visual Cortex Activity Requires the Basal GangliaNeely, Ryan M.Koralek, Aaron C.Athalye, Vivek R.Costa, Rui M.Carmena Ramón, José MiguelBrain-machine interfaceInstrumental conditioningLearningOptogeneticsStriatumVisual cortex32 Ciencias MédicasAnimals acquire behaviors through instrumental conditioning. Brain-machine interfaces have used instrumental conditioning to reinforce patterns of neural activity directly, especially in frontal and motor cortices, which are a rich source of signals for voluntary action. However, evidence suggests that activity in primary sensory cortices may also reflect internally driven processes, instead of purely encoding antecedent stimuli. Here, we show that rats and mice can learn to produce arbitrary patterns of neural activity in their primary visual cortex to control an auditory cursor and obtain reward. Furthermore, learning was prevented when neurons in the dorsomedial striatum (DMS), which receives input from visual cortex, were optogenetically inhibited, but not during inhibition of nearby neurons in the dorsolateral striatum. After learning, DMS inhibition did not affect production of the rewarded patterns. These data demonstrate that cortico-basal ganglia circuits play a general role in learning to produce cortical activity that leads to desirable outcomes.20252025-11-2620182018-03-2120182018-03-21journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12466/7045reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/70452026-06-19T08:32:07Z
dc.title.none.fl_str_mv Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia
title Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia
spellingShingle Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia
Neely, Ryan M.
Brain-machine interface
Instrumental conditioning
Learning
Optogenetics
Striatum
Visual cortex
32 Ciencias Médicas
title_short Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia
title_full Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia
title_fullStr Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia
title_full_unstemmed Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia
title_sort Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia
dc.creator.none.fl_str_mv Neely, Ryan M.
Koralek, Aaron C.
Athalye, Vivek R.
Costa, Rui M.
Carmena Ramón, José Miguel
author Neely, Ryan M.
author_facet Neely, Ryan M.
Koralek, Aaron C.
Athalye, Vivek R.
Costa, Rui M.
Carmena Ramón, José Miguel
author_role author
author2 Koralek, Aaron C.
Athalye, Vivek R.
Costa, Rui M.
Carmena Ramón, José Miguel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Brain-machine interface
Instrumental conditioning
Learning
Optogenetics
Striatum
Visual cortex
32 Ciencias Médicas
topic Brain-machine interface
Instrumental conditioning
Learning
Optogenetics
Striatum
Visual cortex
32 Ciencias Médicas
description Animals acquire behaviors through instrumental conditioning. Brain-machine interfaces have used instrumental conditioning to reinforce patterns of neural activity directly, especially in frontal and motor cortices, which are a rich source of signals for voluntary action. However, evidence suggests that activity in primary sensory cortices may also reflect internally driven processes, instead of purely encoding antecedent stimuli. Here, we show that rats and mice can learn to produce arbitrary patterns of neural activity in their primary visual cortex to control an auditory cursor and obtain reward. Furthermore, learning was prevented when neurons in the dorsomedial striatum (DMS), which receives input from visual cortex, were optogenetically inhibited, but not during inhibition of nearby neurons in the dorsolateral striatum. After learning, DMS inhibition did not affect production of the rewarded patterns. These data demonstrate that cortico-basal ganglia circuits play a general role in learning to produce cortical activity that leads to desirable outcomes.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-03-21
2018
2018-03-21
2025
2025-11-26
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12466/7045
url https://hdl.handle.net/20.500.12466/7045
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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