Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling

Moreno Guillén, Estefanía; Andradas, Clara; Medrano Moya, Mireia; Caffarel, María M.; Pérez-Gómez, Eduardo; Blasco-Benito, Sandra; Gómez-Cañas, María; Pazos, M. Ruth; Irving, Andrew J.; Lluís i Biset, Carme; Canela Campos, Enric I. (Enric Isidre), 1949-; Fernández-Ruiz, Javier; Guzmán, Manuel; McCormick, Peter J.; Sánchez Mora, Cristina

Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling

The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55...

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Detalles Bibliográficos
Autores:	Moreno Guillén, Estefanía, Andradas, Clara, Medrano Moya, Mireia, Caffarel, María M., Pérez-Gómez, Eduardo, Blasco-Benito, Sandra, Gómez-Cañas, María, Pazos, M. Ruth, Irving, Andrew J., Lluís i Biset, Carme, Canela Campos, Enric I. (Enric Isidre), 1949-, Fernández-Ruiz, Javier, Guzmán, Manuel, McCormick, Peter J., Sánchez Mora, Cristina
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2014
País:	España
Institución:	Universidad de Barcelona
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/122587
Acceso en línea:	https://hdl.handle.net/2445/122587
Access Level:	acceso abierto
Palabra clave:	Transducció de senyal cel·lular Càncer Cellular signal transduction Cancer

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spelling	Targeting CB2-GPR55 receptor heteromers modulates cancer cell signalingMoreno Guillén, EstefaníaAndradas, ClaraMedrano Moya, MireiaCaffarel, María M.Pérez-Gómez, EduardoBlasco-Benito, SandraGómez-Cañas, MaríaPazos, M. RuthIrving, Andrew J.Lluís i Biset, CarmeCanela Campos, Enric I. (Enric Isidre), 1949-Fernández-Ruiz, JavierGuzmán, ManuelMcCormick, Peter J.Sánchez Mora, CristinaTransducció de senyal cel·lularCàncerCellular signal transductionCancerThe G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.American Society for Biochemistry and Molecular Biology2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/122587Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1074/jbc.M114.561761Journal of Biological Chemistry, 2014, vol. 289, num. 32, p. 21960-21972https://doi.org/10.1074/jbc.M114.561761(c) American Society for Biochemistry and Molecular Biology, 2014info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1225872026-05-27T06:46:51Z
dc.title.none.fl_str_mv	Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title	Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
spellingShingle	Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling Moreno Guillén, Estefanía Transducció de senyal cel·lular Càncer Cellular signal transduction Cancer
title_short	Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title_full	Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title_fullStr	Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title_full_unstemmed	Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
title_sort	Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
dc.creator.none.fl_str_mv	Moreno Guillén, Estefanía Andradas, Clara Medrano Moya, Mireia Caffarel, María M. Pérez-Gómez, Eduardo Blasco-Benito, Sandra Gómez-Cañas, María Pazos, M. Ruth Irving, Andrew J. Lluís i Biset, Carme Canela Campos, Enric I. (Enric Isidre), 1949- Fernández-Ruiz, Javier Guzmán, Manuel McCormick, Peter J. Sánchez Mora, Cristina
author	Moreno Guillén, Estefanía
author_facet	Moreno Guillén, Estefanía Andradas, Clara Medrano Moya, Mireia Caffarel, María M. Pérez-Gómez, Eduardo Blasco-Benito, Sandra Gómez-Cañas, María Pazos, M. Ruth Irving, Andrew J. Lluís i Biset, Carme Canela Campos, Enric I. (Enric Isidre), 1949- Fernández-Ruiz, Javier Guzmán, Manuel McCormick, Peter J. Sánchez Mora, Cristina
author_role	author
author2	Andradas, Clara Medrano Moya, Mireia Caffarel, María M. Pérez-Gómez, Eduardo Blasco-Benito, Sandra Gómez-Cañas, María Pazos, M. Ruth Irving, Andrew J. Lluís i Biset, Carme Canela Campos, Enric I. (Enric Isidre), 1949- Fernández-Ruiz, Javier Guzmán, Manuel McCormick, Peter J. Sánchez Mora, Cristina
author2_role	author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Transducció de senyal cel·lular Càncer Cellular signal transduction Cancer
topic	Transducció de senyal cel·lular Càncer Cellular signal transduction Cancer
description	The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.
publishDate	2014
dc.date.none.fl_str_mv	2014
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/122587
url	https://hdl.handle.net/2445/122587
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1074/jbc.M114.561761 Journal of Biological Chemistry, 2014, vol. 289, num. 32, p. 21960-21972 https://doi.org/10.1074/jbc.M114.561761
dc.rights.none.fl_str_mv	(c) American Society for Biochemistry and Molecular Biology, 2014 info:eu-repo/semantics/openAccess
rights_invalid_str_mv	(c) American Society for Biochemistry and Molecular Biology, 2014
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	American Society for Biochemistry and Molecular Biology
publisher.none.fl_str_mv	American Society for Biochemistry and Molecular Biology
dc.source.none.fl_str_mv	Articles publicats en revistes (Bioquímica i Biomedicina Molecular) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling

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