Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling

The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55...

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Detalles Bibliográficos
Autores: Moreno Guillén, Estefanía, Andradas, Clara, Medrano Moya, Mireia, Caffarel, María M., Pérez-Gómez, Eduardo, Blasco-Benito, Sandra, Gómez-Cañas, María, Pazos, M. Ruth, Irving, Andrew J., Lluís i Biset, Carme, Canela Campos, Enric I. (Enric Isidre), 1949-, Fernández-Ruiz, Javier, Guzmán, Manuel, McCormick, Peter J., Sánchez Mora, Cristina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/122587
Acceso en línea:https://hdl.handle.net/2445/122587
Access Level:acceso abierto
Palabra clave:Transducció de senyal cel·lular
Càncer
Cellular signal transduction
Cancer
Descripción
Sumario:The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.

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