Reversible effects of the SARS-CoV-2 on semen parameters

Despite that the SARS-CoV-2 pandemic has been controlled, it has affected a large proportion of the population, raising some concerns about potential sequelae in men at reproductive age. To contribute to the clarification of this issue, we performed a retrospective study comparing semen parameters v...

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Detalles Bibliográficos
Autores: Jodar Bifet, Meritxell, Barral, Yasmina, Leiva, Marina, Castillo Corullón, Judit, Barrio, Ruth, Agustí, Inés, Borràs, Aina, Carrillo, Pilar, Matheu, Roger, Ferretti, Roberta, Herrero, Julio, Reimundo, Pilar, Navero-Castillejos, Jessica, Casals, Gemma, Guimerà, Marta, Corral, Juan Manuel, Martinez, Mikel, Carbonell, Melchor, Bassas, Lluís, Manau Trullàs, Dolors, Oliva Virgili, Rafael
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/218988
Acceso en línea:https://hdl.handle.net/2445/218988
Access Level:acceso abierto
Palabra clave:COVID-19
Andrologia
Esterilitat masculina
SARS-CoV-2
Semen
Andrology
Male sterility
Descripción
Sumario:Despite that the SARS-CoV-2 pandemic has been controlled, it has affected a large proportion of the population, raising some concerns about potential sequelae in men at reproductive age. To contribute to the clarification of this issue, we performed a retrospective study comparing semen parameters values before and after confirmed SARS-CoV-2 infection in a large cohort of infertile men, compared to a control group that did not undergo SARS-CoV-2 infection. Wilcoxon test on paired samples and general linear regression model showed that SARS-CoV-2 infection has a detrimental effect on semen volume values (p < 0.005). However, semen volume seems to be significantly lower only during the first spermatogenic cycle after SARS-COV-2 infection (p < 0.005) and mainly in unvaccinated patients (p < 0.05). In addition, we detected alterations in progressive motility in patients infected with the alpha SARS-COV-2 strain (p < 0.05). In conclusion, our results show that although SARS-CoV-2 has a small effect on semen volume and sperm motility in infertile men, depending on the infectious strain or vaccination status, pre-infection values of semen parameters appear to be restored over one spermatogenic cycle after infection.

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