Screening for natural anticancer agents using a fission yeast bioassay
A fission-yeast bioassay guided screening on several plant extracts is carried out to search for anticancer agents, and an extract from leaves of Corema album (L.) D. Don (Ericaceae) is found to have antiproliferative activity. Further fractionation afforded 2′,4′-dihydroxychalcone (DHC) as the main...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/167492 |
| Acceso en línea: | https://hdl.handle.net/11441/167492 https://doi.org/10.1016/j.phytol.2013.09.011 |
| Access Level: | acceso abierto |
| Palabra clave: | 2′ 4′-Dihydroxychalcone (DHC) Antiproliferative Corema album Ericaceae Fission yeast Flavonoid Schizosaccharomyces pombe |
| Sumario: | A fission-yeast bioassay guided screening on several plant extracts is carried out to search for anticancer agents, and an extract from leaves of Corema album (L.) D. Don (Ericaceae) is found to have antiproliferative activity. Further fractionation afforded 2′,4′-dihydroxychalcone (DHC) as the main cytotoxic compound present in the extract. Our detailed biological analysis shows that antiproliferative activity of this flavonoid is likely due to its ability to induce DNA damage which blocks cell cycle progression. |
|---|