The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.

The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological strategies, activators of peroxisome proliferator-acti...

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Autores: Aguilar-Recarte D, Palomer X, Wahli W, Vázquez-Carrera M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p19991
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19991
Access Level:acceso abierto
Palabra clave:AMPK
GDF15
PPARß/d
insulin resistance
type 2 diabetes mellitus
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spelling The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.Aguilar-Recarte DPalomer XWahli WVázquez-Carrera MAMPKGDF15PPARß/dinsulin resistancetype 2 diabetes mellitusThe current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological strategies, activators of peroxisome proliferator-activated receptor (PPAR)ß/d show promise. Remarkably, most of the antidiabetic effects of PPARß/d agonists involve AMP-activated protein kinase (AMPK) activation. This review summarizes the recent mechanistic insights into the antidiabetic effects of the PPARß/d-AMPK pathway, including the upregulation of glucose uptake, muscle remodeling, enhanced fatty acid oxidation, and autophagy, as well as the inhibition of endoplasmic reticulum stress and inflammation. A better understanding of the mechanisms underlying the effects resulting from the PPARß/d-AMPK pathway may provide the basis for the development of new therapies in the prevention and treatment of insulin resistance and type 2 diabetes mellitus.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19991INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESISSN: 16616596ISSNe: 14220067reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p199912026-05-27T12:37:41Z
dc.title.none.fl_str_mv The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.
title The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.
spellingShingle The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.
Aguilar-Recarte D
AMPK
GDF15
PPARß/d
insulin resistance
type 2 diabetes mellitus
title_short The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.
title_full The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.
title_fullStr The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.
title_full_unstemmed The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.
title_sort The PPARß/d-AMPK Connection in the Treatment of Insulin Resistance.
dc.creator.none.fl_str_mv Aguilar-Recarte D
Palomer X
Wahli W
Vázquez-Carrera M
author Aguilar-Recarte D
author_facet Aguilar-Recarte D
Palomer X
Wahli W
Vázquez-Carrera M
author_role author
author2 Palomer X
Wahli W
Vázquez-Carrera M
author2_role author
author
author
dc.subject.none.fl_str_mv AMPK
GDF15
PPARß/d
insulin resistance
type 2 diabetes mellitus
topic AMPK
GDF15
PPARß/d
insulin resistance
type 2 diabetes mellitus
description The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological strategies, activators of peroxisome proliferator-activated receptor (PPAR)ß/d show promise. Remarkably, most of the antidiabetic effects of PPARß/d agonists involve AMP-activated protein kinase (AMPK) activation. This review summarizes the recent mechanistic insights into the antidiabetic effects of the PPARß/d-AMPK pathway, including the upregulation of glucose uptake, muscle remodeling, enhanced fatty acid oxidation, and autophagy, as well as the inhibition of endoplasmic reticulum stress and inflammation. A better understanding of the mechanisms underlying the effects resulting from the PPARß/d-AMPK pathway may provide the basis for the development of new therapies in the prevention and treatment of insulin resistance and type 2 diabetes mellitus.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19991
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=19991
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN: 16616596
ISSNe: 14220067
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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