Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothers

This article belongs to the Special Issue New Challenges and Opportunities of Food Digestion.

Detalles Bibliográficos
Autores: Sánchez-Hernández, Silvia, Théron, Laëtitia, Jiménez-Barrios, Pablo, Olalla-Herrera, Manuel, Recio, Isidra, Miralles, Beatriz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/263345
Acceso en línea:http://hdl.handle.net/10261/263345
Access Level:acceso abierto
Palabra clave:Human milk
Bioactive proteins
MALDI mass spectrometry
In vitro infant digestion
Body mass index
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spelling Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothersSánchez-Hernández, SilviaThéron, LaëtitiaJiménez-Barrios, PabloOlalla-Herrera, ManuelRecio, IsidraMiralles, BeatrizHuman milkBioactive proteinsMALDI mass spectrometryIn vitro infant digestionBody mass indexThis article belongs to the Special Issue New Challenges and Opportunities of Food Digestion.Human milk proteins have shown to vary in concentration and distribution through lactation. However, while some regulatory components, such as hormones, have shown associations with regard to the mothers’ body mass index, there is limited information on the possible influence of this condition on the whole protein distribution. The objective of this study was to evaluate the protein profile of human milk from normal weight and overweight or obese mothers to identify differences in protein expression in colostrum, transitional and mature milk. The mass spectrometry analysis showed the ability to class with a high degree of confidence the lactation state and the milk profile according to the mother’s condition. Individual milk samples were subjected to a digestion in vitro model that takes into account the specificities of the gastrointestinal conditions of full-term newborn infants. The digestion products were compared with available data from the digestive contents in newborns. The behavior of the most abundant proteins and the overall peptide generation and survival, showed good correspondence with in vivo data.This project was supported by project PID2019-107663RB-I00 from Ministry of Science and Innovation (MICINN). S.S.-H. is the recipient of FPU grant (FPU15-04549) from the Spanish Ministry of Education, Culture and Sports.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Ministerio de Educación, Cultura y Deporte (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/263345reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107663RB-I00https://doi.org/10.3390/foods10040887Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2633452026-05-22T06:33:51Z
dc.title.none.fl_str_mv Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothers
title Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothers
spellingShingle Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothers
Sánchez-Hernández, Silvia
Human milk
Bioactive proteins
MALDI mass spectrometry
In vitro infant digestion
Body mass index
title_short Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothers
title_full Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothers
title_fullStr Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothers
title_full_unstemmed Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothers
title_sort Protein profile and simulated digestive behavior of breast milk from overweight and normal weight mothers
dc.creator.none.fl_str_mv Sánchez-Hernández, Silvia
Théron, Laëtitia
Jiménez-Barrios, Pablo
Olalla-Herrera, Manuel
Recio, Isidra
Miralles, Beatriz
author Sánchez-Hernández, Silvia
author_facet Sánchez-Hernández, Silvia
Théron, Laëtitia
Jiménez-Barrios, Pablo
Olalla-Herrera, Manuel
Recio, Isidra
Miralles, Beatriz
author_role author
author2 Théron, Laëtitia
Jiménez-Barrios, Pablo
Olalla-Herrera, Manuel
Recio, Isidra
Miralles, Beatriz
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Ministerio de Educación, Cultura y Deporte (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Human milk
Bioactive proteins
MALDI mass spectrometry
In vitro infant digestion
Body mass index
topic Human milk
Bioactive proteins
MALDI mass spectrometry
In vitro infant digestion
Body mass index
description This article belongs to the Special Issue New Challenges and Opportunities of Food Digestion.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/263345
url http://hdl.handle.net/10261/263345
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-107663RB-I00
https://doi.org/10.3390/foods10040887
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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