A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma

Encinas, C; Hernandez-Rivas, JA; Oriol, A; Rosinol, L; Blanchard, MJ; Bellon, JM; Garcia-Sanz, R; de la Rubia, J; de la Guia, AL; Jimenez-Ubieto, A; Jarque, I; Inigo, B; Dourdil, V; de Arriba, F; Perez-Avila, CC; Gonzalez, Y; Hernandez, MT; Bargay, J; Granell, M; Rodriguez-Otero, P; Silvent, M; Cabrera, C; Rios, R; Alegre, A; Gironella, M; Gonzalez, MS; Sureda, A; Sampol, A; Ocio, EM; Krsnik, I; Garcia, A; Garcia-Mateo, A; Soler, JA; Martin, J; Arguinano, JM; Mateos, MV; Blade, J; San-Miguel, JF; Lahuerta, JJ; Martinez-Lopez, J

A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma

Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc a...

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Autores:	Encinas, C, Hernandez-Rivas, JA, Oriol, A, Rosinol, L, Blanchard, MJ, Bellon, JM, Garcia-Sanz, R, de la Rubia, J, de la Guia, AL, Jimenez-Ubieto, A, Jarque, I, Inigo, B, Dourdil, V, de Arriba, F, Perez-Avila, CC, Gonzalez, Y, Hernandez, MT, Bargay, J, Granell, M, Rodriguez-Otero, P, Silvent, M, Cabrera, C, Rios, R, Alegre, A, Gironella, M, Gonzalez, MS, Sureda, A, Sampol, A, Ocio, EM, Krsnik, I, Garcia, A, Garcia-Mateo, A, Soler, JA, Martin, J, Arguinano, JM, Mateos, MV, Blade, J, San-Miguel, JF, Lahuerta, JJ, Martinez-Lopez, J
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Institución:	Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:	oai:i3pt.fundanetsuite.com:p1369
Acceso en línea:	https://i3pt.portalinvestigacion.com/publicaciones/1369 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128796138&doi=10.1038%2fs41408-022-00652-2&partnerID=40&md5=e32bafd6508c2412c36c438218bc7ae9
Access Level:	acceso abierto
Palabra clave:	Antibiotic Prophylaxis Humans Male Multiple Myeloma antibiotic agent serum albumin adult antibiotic therapy Article cancer patient controlled study data analysis software disease severity ECOG Performance Status female high risk patient high risk population human incidence infection intermediate risk patient low risk patient major clinical study male middle aged multiple myeloma overall survival scoring system transplantation antibiotic prophylaxis complication

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spelling	A simple score to predict early severe infections in patients with newly diagnosed multiple myelomaEncinas, CHernandez-Rivas, JAOriol, ARosinol, LBlanchard, MJBellon, JMGarcia-Sanz, Rde la Rubia, Jde la Guia, ALJimenez-Ubieto, AJarque, IInigo, BDourdil, Vde Arriba, FPerez-Avila, CCGonzalez, YHernandez, MTBargay, JGranell, MRodriguez-Otero, PSilvent, MCabrera, CRios, RAlegre, AGironella, MGonzalez, MSSureda, ASampol, AOcio, EMKrsnik, IGarcia, AGarcia-Mateo, ASoler, JAMartin, JArguinano, JMMateos, MVBlade, JSan-Miguel, JFLahuerta, JJMartinez-Lopez, JAntibiotic ProphylaxisHumansMaleMultiple Myelomaantibiotic agentserum albuminadultantibiotic therapyArticlecancer patientcontrolled studydata analysis softwaredisease severityECOG Performance Statusfemalehigh risk patienthigh risk populationhumanincidenceinfectionintermediate risk patientlow risk patientmajor clinical studymalemiddle agedmultiple myelomaoverall survivalscoring systemtransplantationantibiotic prophylaxiscomplicationmultiple myelomaInfections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin <= 30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies.SPRINGERNATURE2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/1369https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128796138&doi=10.1038%2fs41408-022-00652-2&partnerID=40&md5=e32bafd6508c2412c36c438218bc7ae9Blood Cancer JournalISSN: 20445385reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p13692026-06-21T15:30:37Z
dc.title.none.fl_str_mv	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
spellingShingle	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma Encinas, C Antibiotic Prophylaxis Humans Male Multiple Myeloma antibiotic agent serum albumin adult antibiotic therapy Article cancer patient controlled study data analysis software disease severity ECOG Performance Status female high risk patient high risk population human incidence infection intermediate risk patient low risk patient major clinical study male middle aged multiple myeloma overall survival scoring system transplantation antibiotic prophylaxis complication multiple myeloma
title_short	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title_full	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title_fullStr	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title_full_unstemmed	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
title_sort	A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
dc.creator.none.fl_str_mv	Encinas, C Hernandez-Rivas, JA Oriol, A Rosinol, L Blanchard, MJ Bellon, JM Garcia-Sanz, R de la Rubia, J de la Guia, AL Jimenez-Ubieto, A Jarque, I Inigo, B Dourdil, V de Arriba, F Perez-Avila, CC Gonzalez, Y Hernandez, MT Bargay, J Granell, M Rodriguez-Otero, P Silvent, M Cabrera, C Rios, R Alegre, A Gironella, M Gonzalez, MS Sureda, A Sampol, A Ocio, EM Krsnik, I Garcia, A Garcia-Mateo, A Soler, JA Martin, J Arguinano, JM Mateos, MV Blade, J San-Miguel, JF Lahuerta, JJ Martinez-Lopez, J
author	Encinas, C
author_facet	Encinas, C Hernandez-Rivas, JA Oriol, A Rosinol, L Blanchard, MJ Bellon, JM Garcia-Sanz, R de la Rubia, J de la Guia, AL Jimenez-Ubieto, A Jarque, I Inigo, B Dourdil, V de Arriba, F Perez-Avila, CC Gonzalez, Y Hernandez, MT Bargay, J Granell, M Rodriguez-Otero, P Silvent, M Cabrera, C Rios, R Alegre, A Gironella, M Gonzalez, MS Sureda, A Sampol, A Ocio, EM Krsnik, I Garcia, A Garcia-Mateo, A Soler, JA Martin, J Arguinano, JM Mateos, MV Blade, J San-Miguel, JF Lahuerta, JJ Martinez-Lopez, J
author_role	author
author2	Hernandez-Rivas, JA Oriol, A Rosinol, L Blanchard, MJ Bellon, JM Garcia-Sanz, R de la Rubia, J de la Guia, AL Jimenez-Ubieto, A Jarque, I Inigo, B Dourdil, V de Arriba, F Perez-Avila, CC Gonzalez, Y Hernandez, MT Bargay, J Granell, M Rodriguez-Otero, P Silvent, M Cabrera, C Rios, R Alegre, A Gironella, M Gonzalez, MS Sureda, A Sampol, A Ocio, EM Krsnik, I Garcia, A Garcia-Mateo, A Soler, JA Martin, J Arguinano, JM Mateos, MV Blade, J San-Miguel, JF Lahuerta, JJ Martinez-Lopez, J
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Antibiotic Prophylaxis Humans Male Multiple Myeloma antibiotic agent serum albumin adult antibiotic therapy Article cancer patient controlled study data analysis software disease severity ECOG Performance Status female high risk patient high risk population human incidence infection intermediate risk patient low risk patient major clinical study male middle aged multiple myeloma overall survival scoring system transplantation antibiotic prophylaxis complication multiple myeloma
topic	Antibiotic Prophylaxis Humans Male Multiple Myeloma antibiotic agent serum albumin adult antibiotic therapy Article cancer patient controlled study data analysis software disease severity ECOG Performance Status female high risk patient high risk population human incidence infection intermediate risk patient low risk patient major clinical study male middle aged multiple myeloma overall survival scoring system transplantation antibiotic prophylaxis complication multiple myeloma
description	Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin <= 30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies.
publishDate	2022
dc.date.none.fl_str_mv	2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://i3pt.portalinvestigacion.com/publicaciones/1369 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128796138&doi=10.1038%2fs41408-022-00652-2&partnerID=40&md5=e32bafd6508c2412c36c438218bc7ae9
url	https://i3pt.portalinvestigacion.com/publicaciones/1369 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85128796138&doi=10.1038%2fs41408-022-00652-2&partnerID=40&md5=e32bafd6508c2412c36c438218bc7ae9
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	SPRINGERNATURE
publisher.none.fl_str_mv	SPRINGERNATURE
dc.source.none.fl_str_mv	Blood Cancer Journal ISSN: 20445385 reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str	Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
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A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma

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