Rev1 wbdR tagged vaccines against Brucella ovis

Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B....

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Detalles Bibliográficos
Autores: Aragón-Aranda, B. (Beatriz)|||/items/66f8021d-2d13-4715-add1-c9ffb8fecee0, de-Miguel, M.J. (María Jesús)|||/items/cfc74851-e6d4-4126-a8f6-71e55b7e72f7, Martinez-Gomez, E. (Estrella)|||/items/eef0c320-cc26-4081-af8e-217387c740e7, Zuñiga-Ripa, A. (Amaia)|||/items/9aa6da2e-e507-4319-a12c-092436f70feb, Salvador-Bescós, M. (Miriam)|||/items/a4486903-a513-490f-a527-2eb66eac4388, Moriyon, I. (Ignacio)|||/items/834b4ce9-a879-4ba7-8884-39d0ddd88c7b, Iriarte-Cilveti, M. (Maite)|||/items/5b20b123-3967-4f07-b577-13d13aa57363, Muñoz, P. (Pilar)|||/items/4e98f4c8-d3e4-4fb3-b781-07a0bcb652bc, Conde-Álvarez, R. (Raquel)|||/items/7a805559-3962-434b-9df9-ec243d61b5aa
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/69674
Acceso en línea:https://hdl.handle.net/10171/69674
Access Level:acceso abierto
Palabra clave:B. melitensis
B. ovis
Rev1
WbkC
WbdR
id ES_7e4e3ca38ef9ea30ab018e00a5e37998
oai_identifier_str oai:dadun.unav.edu:10171/69674
network_acronym_str ES
network_name_str España
repository_id_str
spelling Rev1 wbdR tagged vaccines against Brucella ovisAragón-Aranda, B. (Beatriz)|||/items/66f8021d-2d13-4715-add1-c9ffb8fecee0de-Miguel, M.J. (María Jesús)|||/items/cfc74851-e6d4-4126-a8f6-71e55b7e72f7Martinez-Gomez, E. (Estrella)|||/items/eef0c320-cc26-4081-af8e-217387c740e7Zuñiga-Ripa, A. (Amaia)|||/items/9aa6da2e-e507-4319-a12c-092436f70febSalvador-Bescós, M. (Miriam)|||/items/a4486903-a513-490f-a527-2eb66eac4388Moriyon, I. (Ignacio)|||/items/834b4ce9-a879-4ba7-8884-39d0ddd88c7bIriarte-Cilveti, M. (Maite)|||/items/5b20b123-3967-4f07-b577-13d13aa57363Muñoz, P. (Pilar)|||/items/4e98f4c8-d3e4-4fb3-b781-07a0bcb652bcConde-Álvarez, R. (Raquel)|||/items/7a805559-3962-434b-9df9-ec243d61b5aaB. melitensisB. ovisRev1WbkCWbdRSheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.Dadun. Depósito Académico Digital Universidad de Navarra20242024-07-1720192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/69674reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/696742026-06-21T12:47:57Z
dc.title.none.fl_str_mv Rev1 wbdR tagged vaccines against Brucella ovis
title Rev1 wbdR tagged vaccines against Brucella ovis
spellingShingle Rev1 wbdR tagged vaccines against Brucella ovis
Aragón-Aranda, B. (Beatriz)|||/items/66f8021d-2d13-4715-add1-c9ffb8fecee0
B. melitensis
B. ovis
Rev1
WbkC
WbdR
title_short Rev1 wbdR tagged vaccines against Brucella ovis
title_full Rev1 wbdR tagged vaccines against Brucella ovis
title_fullStr Rev1 wbdR tagged vaccines against Brucella ovis
title_full_unstemmed Rev1 wbdR tagged vaccines against Brucella ovis
title_sort Rev1 wbdR tagged vaccines against Brucella ovis
dc.creator.none.fl_str_mv Aragón-Aranda, B. (Beatriz)|||/items/66f8021d-2d13-4715-add1-c9ffb8fecee0
de-Miguel, M.J. (María Jesús)|||/items/cfc74851-e6d4-4126-a8f6-71e55b7e72f7
Martinez-Gomez, E. (Estrella)|||/items/eef0c320-cc26-4081-af8e-217387c740e7
Zuñiga-Ripa, A. (Amaia)|||/items/9aa6da2e-e507-4319-a12c-092436f70feb
Salvador-Bescós, M. (Miriam)|||/items/a4486903-a513-490f-a527-2eb66eac4388
Moriyon, I. (Ignacio)|||/items/834b4ce9-a879-4ba7-8884-39d0ddd88c7b
Iriarte-Cilveti, M. (Maite)|||/items/5b20b123-3967-4f07-b577-13d13aa57363
Muñoz, P. (Pilar)|||/items/4e98f4c8-d3e4-4fb3-b781-07a0bcb652bc
Conde-Álvarez, R. (Raquel)|||/items/7a805559-3962-434b-9df9-ec243d61b5aa
author Aragón-Aranda, B. (Beatriz)|||/items/66f8021d-2d13-4715-add1-c9ffb8fecee0
author_facet Aragón-Aranda, B. (Beatriz)|||/items/66f8021d-2d13-4715-add1-c9ffb8fecee0
de-Miguel, M.J. (María Jesús)|||/items/cfc74851-e6d4-4126-a8f6-71e55b7e72f7
Martinez-Gomez, E. (Estrella)|||/items/eef0c320-cc26-4081-af8e-217387c740e7
Zuñiga-Ripa, A. (Amaia)|||/items/9aa6da2e-e507-4319-a12c-092436f70feb
Salvador-Bescós, M. (Miriam)|||/items/a4486903-a513-490f-a527-2eb66eac4388
Moriyon, I. (Ignacio)|||/items/834b4ce9-a879-4ba7-8884-39d0ddd88c7b
Iriarte-Cilveti, M. (Maite)|||/items/5b20b123-3967-4f07-b577-13d13aa57363
Muñoz, P. (Pilar)|||/items/4e98f4c8-d3e4-4fb3-b781-07a0bcb652bc
Conde-Álvarez, R. (Raquel)|||/items/7a805559-3962-434b-9df9-ec243d61b5aa
author_role author
author2 de-Miguel, M.J. (María Jesús)|||/items/cfc74851-e6d4-4126-a8f6-71e55b7e72f7
Martinez-Gomez, E. (Estrella)|||/items/eef0c320-cc26-4081-af8e-217387c740e7
Zuñiga-Ripa, A. (Amaia)|||/items/9aa6da2e-e507-4319-a12c-092436f70feb
Salvador-Bescós, M. (Miriam)|||/items/a4486903-a513-490f-a527-2eb66eac4388
Moriyon, I. (Ignacio)|||/items/834b4ce9-a879-4ba7-8884-39d0ddd88c7b
Iriarte-Cilveti, M. (Maite)|||/items/5b20b123-3967-4f07-b577-13d13aa57363
Muñoz, P. (Pilar)|||/items/4e98f4c8-d3e4-4fb3-b781-07a0bcb652bc
Conde-Álvarez, R. (Raquel)|||/items/7a805559-3962-434b-9df9-ec243d61b5aa
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv B. melitensis
B. ovis
Rev1
WbkC
WbdR
topic B. melitensis
B. ovis
Rev1
WbkC
WbdR
description Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyl-transferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be differentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
2024
2024-07-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/69674
url https://hdl.handle.net/10171/69674
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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