Rev1 wbdR tagged vaccines against Brucella ovis

Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B....

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Detalles Bibliográficos
Autores: Aragón-Aranda, B. (Beatriz)|||/items/66f8021d-2d13-4715-add1-c9ffb8fecee0, Miguel, M.J. (María Jesús) de|||/items/4968c547-5897-4fb3-86c1-d860c9ba4861, Martinez-Gomez, E. (Estrella)|||/items/eef0c320-cc26-4081-af8e-217387c740e7, Zuñiga-Ripa, A. (Amaia)|||/items/9aa6da2e-e507-4319-a12c-092436f70feb, Salvador-Bescós, M. (Miriam)|||/items/a4486903-a513-490f-a527-2eb66eac4388, Moriyon, I. (Ignacio)|||/items/834b4ce9-a879-4ba7-8884-39d0ddd88c7b, Muñoz, P. (Pilar)|||/items/4e98f4c8-d3e4-4fb3-b781-07a0bcb652bc, Conde-Álvarez, R. (Raquel)|||/items/7a805559-3962-434b-9df9-ec243d61b5aa, Iriarte-Cilveti, M. (Maite)|||/items/5b20b123-3967-4f07-b577-13d13aa57363
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/61550
Acceso en línea:https://hdl.handle.net/10171/61550
Access Level:acceso abierto
Palabra clave:Materias Investigacion::Ciencias de la vida::Inmunología
Descripción
Sumario:Sheep brucellosis is a worldwide extended disease caused by B. melitensis and B. ovis, two species respectively carrying smooth or rough lipopolysaccharide. Vaccine B. melitensis Rev1 is used against B. melitensis and B. ovis but induces an anti-smooth-lipopolysaccharide response interfering with B. melitensis serodiagnosis, which precludes its use against B. ovis where B. melitensis is absent. In mice, Rev1 deleted in wbkC (Brucella lipopolysaccharide formyltransferase) and carrying wbdR (E. coli acetyl-transferase) triggered antibodies that could be diferentiated from those evoked by wild-type strains, was comparatively attenuated and protected against B. ovis, suggesting its potential as a B. ovis vaccine.

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