Tratamiento farmacológico del dolor en dos modelos experimentales de fibromialgia en ratón
ENG- Fibromyalgia syndrome is a chronic disease that presents chronic diffuse musculoskeletal pain combined with fatigue, sleep alterations and cognitive alterations. Currently, about 2.3% of the world's population suffers from this syndrome, being more prevalent in women than in men. Due to th...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/694761 |
| Acceso en línea: | http://hdl.handle.net/10803/694761 |
| Access Level: | acceso abierto |
| Palabra clave: | Dolor Pain Fibromiàlgia Fibromialgia Fibromyalgia Nociplàstic Nociplástico Nociplastic Reserpina Reserpine Sigma-1 616.8 |
| Sumario: | ENG- Fibromyalgia syndrome is a chronic disease that presents chronic diffuse musculoskeletal pain combined with fatigue, sleep alterations and cognitive alterations. Currently, about 2.3% of the world's population suffers from this syndrome, being more prevalent in women than in men. Due to the difficulty of diagnostic and treatment, animal models are required that present the most frequent symptoms that humans allow for the study of pathophysiology of the disease, research and treatment of animals. In the present thesis it has been observed that repeated subcutaneous administration of reserpine (RIM) and intramuscular injections of acidified saline solution (ASI) cause the appearance of pain as thermal hyperalgesia. These two models also show depressive behavior. When treating these animals with pregabalin, drug of use in the treatment of fibromyalgia, the pain symptoms were diminished but not permanently, while depressive ones were only reduced in the ASI model. The antagonist treatment of the Sigma-1 receptor (BD1063) will permanently reduce the pain symptoms in the RIM model and also the depressive symptoms in the long term. All of these painful and depressive changes could be caused by cellular alterations (astrogliosis and microgliosis), observed by the means of histological techniques in the spinal cord, since the treatment with these two drugs modulate the activation of these cells. In summary, the results obtained suggest that the two experimental models are suitable models for the disease of fibromyalgia, because the animals showed the main symptoms, and it is demonstrated that the sigma-1 receptor could be a very interesting therapeutic target to treat the symptoms of this illness |
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