Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy

Magnetic Fluid Hyperthermia mediated by iron oxide nanoparticles is one of the most promising therapies for cancer treatment. Among the different candidates, magnetite and maghemite nanoparticles have revealed to be some of the most promising candidates due to both their performance and their biocom...

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Autores: Martín Jefremovas, Elizabeth|||0000-0001-8501-058X, Gandarias, Lucía, Rodrigo, Irati, Marcano, Lourdes, Grüttner, Cordula, García, José Ángel, Garayo, Eneko, Orue, Iñaki, García-Prieto, Ana, Muela, Alicia, Fernández-Gubieda, María Luisa, Alonso Masa, Javier|||0000-0003-0045-5390, Fernández Barquín, Luis|||0000-0003-4722-3722
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/23070
Acceso en línea:http://hdl.handle.net/10902/23070
Access Level:acceso abierto
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spelling Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia TherapyMartín Jefremovas, Elizabeth|||0000-0001-8501-058X Gandarias, LucíaRodrigo, IratiMarcano, LourdesGrüttner, CordulaGarcía, José ÁngelGarayo, EnekoOrue, IñakiGarcía-Prieto, AnaMuela, AliciaFernández-Gubieda, María LuisaAlonso Masa, Javier|||0000-0003-0045-5390Fernández Barquín, Luis|||0000-0003-4722-3722Magnetic Fluid Hyperthermia mediated by iron oxide nanoparticles is one of the most promising therapies for cancer treatment. Among the different candidates, magnetite and maghemite nanoparticles have revealed to be some of the most promising candidates due to both their performance and their biocompatibility. Nonetheless, up to date, the literature comparing the heating ef ciency of magnetite and maghemite nanoparticles of similar size is scarce. To ll this gap, here we provide a comparison between commercial Synomag Nano owers (pure maghemite) and bacterial magnetosomes (pure magnetite) synthesized by the magnetotactic bacterium Magnetospirillum gryphiswaldense of hDi 40 45 nm. Both types of nanoparticles exhibit a high degree of crystallinity and an excellent degree of chemical purity and stability. The structural and magnetic properties in both nanoparticle ensembles have been studied by means of X Ray Diffraction, Transmission Electron Microscopy, X Ray Absorption Spectroscopy, and SQUID magnetometry. The heating ef ciency has been analyzed in both systems using AC magnetometry at several eld amplitudes (0 88 mT) and frequencies (130, 300, and 530 kHz).This work was supported in part by the Spanish "Ministerio de Ciencia, Investigación y Universidades'' under Project MAT2017-83631-C3-R, and in part by the Nanotechnology in Translational Hyperthermia (HIPERNANO) under Grant RED2018-102626-T. The work of Elizabeth M. Jefremovas was supported by the Beca Concepción Arenal through the Gobierno de Cantabria-Universidad de Cantabria under Grant BDNS: 406333. The work of Irati Rodrigo was supported by the Programa de Perfeccionamiento de Personal Investigador Doctor (Gobierno Vasco) under Grant POS-2020-1-0028 and Grant IT-1005-16. The work of Lourdes Marcano was supported by the Postdoctoral Fellowship from the Basque Government under Grant POS-2019-2-0017.Institute of Electrical and Electronics Engineers, Inc.Universidad de Cantabria20212021-07-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/23070IEEE Access, vol. 9, pp. 99552-99561, 2021reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/230702026-06-02T12:39:31Z
dc.title.none.fl_str_mv Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy
title Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy
spellingShingle Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy
Martín Jefremovas, Elizabeth|||0000-0001-8501-058X
title_short Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy
title_full Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy
title_fullStr Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy
title_full_unstemmed Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy
title_sort Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy
dc.creator.none.fl_str_mv Martín Jefremovas, Elizabeth|||0000-0001-8501-058X
Gandarias, Lucía
Rodrigo, Irati
Marcano, Lourdes
Grüttner, Cordula
García, José Ángel
Garayo, Eneko
Orue, Iñaki
García-Prieto, Ana
Muela, Alicia
Fernández-Gubieda, María Luisa
Alonso Masa, Javier|||0000-0003-0045-5390
Fernández Barquín, Luis|||0000-0003-4722-3722
author Martín Jefremovas, Elizabeth|||0000-0001-8501-058X
author_facet Martín Jefremovas, Elizabeth|||0000-0001-8501-058X
Gandarias, Lucía
Rodrigo, Irati
Marcano, Lourdes
Grüttner, Cordula
García, José Ángel
Garayo, Eneko
Orue, Iñaki
García-Prieto, Ana
Muela, Alicia
Fernández-Gubieda, María Luisa
Alonso Masa, Javier|||0000-0003-0045-5390
Fernández Barquín, Luis|||0000-0003-4722-3722
author_role author
author2 Gandarias, Lucía
Rodrigo, Irati
Marcano, Lourdes
Grüttner, Cordula
García, José Ángel
Garayo, Eneko
Orue, Iñaki
García-Prieto, Ana
Muela, Alicia
Fernández-Gubieda, María Luisa
Alonso Masa, Javier|||0000-0003-0045-5390
Fernández Barquín, Luis|||0000-0003-4722-3722
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
description Magnetic Fluid Hyperthermia mediated by iron oxide nanoparticles is one of the most promising therapies for cancer treatment. Among the different candidates, magnetite and maghemite nanoparticles have revealed to be some of the most promising candidates due to both their performance and their biocompatibility. Nonetheless, up to date, the literature comparing the heating ef ciency of magnetite and maghemite nanoparticles of similar size is scarce. To ll this gap, here we provide a comparison between commercial Synomag Nano owers (pure maghemite) and bacterial magnetosomes (pure magnetite) synthesized by the magnetotactic bacterium Magnetospirillum gryphiswaldense of hDi 40 45 nm. Both types of nanoparticles exhibit a high degree of crystallinity and an excellent degree of chemical purity and stability. The structural and magnetic properties in both nanoparticle ensembles have been studied by means of X Ray Diffraction, Transmission Electron Microscopy, X Ray Absorption Spectroscopy, and SQUID magnetometry. The heating ef ciency has been analyzed in both systems using AC magnetometry at several eld amplitudes (0 88 mT) and frequencies (130, 300, and 530 kHz).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-07-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/23070
url http://hdl.handle.net/10902/23070
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers, Inc.
publisher.none.fl_str_mv Institute of Electrical and Electronics Engineers, Inc.
dc.source.none.fl_str_mv IEEE Access, vol. 9, pp. 99552-99561, 2021
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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