Nanoflowers Versus Magnetosomes: Comparison Between Two Promising Candidates for Magnetic Hyperthermia Therapy

Magnetic Fluid Hyperthermia mediated by iron oxide nanoparticles is one of the most promising therapies for cancer treatment. Among the different candidates, magnetite and maghemite nanoparticles have revealed to be some of the most promising candidates due to both their performance and their biocom...

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Detalles Bibliográficos
Autores: Martín Jefremovas, Elizabeth|||0000-0001-8501-058X, Gandarias, Lucía, Rodrigo, Irati, Marcano, Lourdes, Grüttner, Cordula, García, José Ángel, Garayo, Eneko, Orue, Iñaki, García-Prieto, Ana, Muela, Alicia, Fernández-Gubieda, María Luisa, Alonso Masa, Javier|||0000-0003-0045-5390, Fernández Barquín, Luis|||0000-0003-4722-3722
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/23070
Acceso en línea:http://hdl.handle.net/10902/23070
Access Level:acceso abierto
Descripción
Sumario:Magnetic Fluid Hyperthermia mediated by iron oxide nanoparticles is one of the most promising therapies for cancer treatment. Among the different candidates, magnetite and maghemite nanoparticles have revealed to be some of the most promising candidates due to both their performance and their biocompatibility. Nonetheless, up to date, the literature comparing the heating ef ciency of magnetite and maghemite nanoparticles of similar size is scarce. To ll this gap, here we provide a comparison between commercial Synomag Nano owers (pure maghemite) and bacterial magnetosomes (pure magnetite) synthesized by the magnetotactic bacterium Magnetospirillum gryphiswaldense of hDi 40 45 nm. Both types of nanoparticles exhibit a high degree of crystallinity and an excellent degree of chemical purity and stability. The structural and magnetic properties in both nanoparticle ensembles have been studied by means of X Ray Diffraction, Transmission Electron Microscopy, X Ray Absorption Spectroscopy, and SQUID magnetometry. The heating ef ciency has been analyzed in both systems using AC magnetometry at several eld amplitudes (0 88 mT) and frequencies (130, 300, and 530 kHz).