Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome

It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort...

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Detalles Bibliográficos
Autores: Diaz-Lopez, Andres, Paz-Graniel, Indira, Ruiz-Pizarro, Virginia, Toledo, Estefanía, Becerra-Tomas, Nerea, Corella, Dolores, Castañer-Niño, Olga, Martinez, J. Alfredo, Alonso-Gomez, Angel M., Wärnberg, Julia, Vioque, Jesus, Romaguera, Dora, Lopez-Miranda, Jose, Estruch, Ramon, Tinahones, Francisco J, Lapetra, Jose, Serra-Majem, Lluis, Bueno-Cavanillas, Aurora, Tur, Josep A., Sanchez, Vicente Martin, Pinto, Xavier, Delgado-Rodriguez, Miguel, Matia-Martin, Pilar, Vidal, Josep, Vazquez, Clotilde, Daimiel, Lidia, Villa, Tania Fernandez, Ros, Emilio, Eguaras, Sonia, Babio, Nancy, Sorli, Jose V., Goday, Albert, Abete, Itziar, Tojal-Sierra, Lucas, Barón-López, Francisco Javier, Torres-Collado, Laura, Morey, Margalida, Garcia-Rios, Antonio, Casas, Rosa, Rosa Bernal-Lopez, Maria, Santos-Lozano, José Manuel, Navarro, Adela, Gonzalez, Jose I., Zomeño-Fajardo, María Dolores, Zulet, Maria Angeles, Luna, Jessica Vaquero, Ramallal, Raul, Fito, Montserrat, Salas-Salvado, Jordi
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/19512
Acceso en línea:https://hdl.handle.net/20.500.13003/19512
Access Level:acceso abierto
Palabra clave:Metabolic Syndrome
Aged
Drinking Behavior
Spain
Coffee
Humans
Kidney
Middle Aged
Caffeine
Male
Female
Cohort Studies
Glomerular Filtration Rate
Tea
Estudios de Cohortes
Té
Síndrome Metabólico
Femenino
Masculino
Cafeína
Riñón
Café
Conducta de Ingestión de Líquido
Humanos
Persona de Mediana Edad
Anciano
Tasa de Filtración Glomerular
España
Descripción
Sumario:It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and 1-year changes in glomerular filtration rate (eGFR) in a large Spanish cohort of overweight/obese elderly with metabolic syndrome (MetS). This prospective analysis includes 5851 overweight/obese adults (55-75 years) with MetS from the PREDIMED-Plus study. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation. Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Caffeinated coffee (> 2 cups/day) and tea (at least 1 cup/day) drinkers had 0.88 and 0.93 mL/min/1.73 m(2) greater eGFR decrease respectively, compared to those with less than 1 cup/day of coffee consumption or non-tea drinkers. Furthermore, caffeinated coffee consumption of > 2 cups/day was associated with 1.19-fold increased risk of rapid eGFR decline > 3 mL/min/1.73 m(2) (95% CI 1.01-1.41). Similarly, individuals in the highest (median, 51.2 mg/day) tertile of caffeine intake had a 0.87 mL/min/1.73 m(2) greater eGFR decrease. Decaffeinated coffee was not associated with eGFR changes. In conclusion, higher consumption of caffeinated coffee, tea, and caffeine was associated with a greater 1-year eGFR decline in overweight/obese adults with MetS.

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