Wireless electrical–molecular quantum signalling for cancer cell apoptosis
<p>Quantum biological tunnelling for electron transfer is involved in</p><p>controlling essential functions for life such as cellular respiration and</p><p>homoeostasis. Understanding and controlling the quantum effects in</p><p>biology has the potential to...
| Autores: | , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/208249 |
| Acceso en línea: | https://hdl.handle.net/2445/208249 |
| Access Level: | acceso abierto |
| Palabra clave: | Nanotecnologia Electroquímica Bioelectrònica Nanotechnology Electrochemistry Bioelectronics |
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Wireless electrical–molecular quantum signalling for cancer cell apoptosisSmith, StuartJain, AkhilGosling, JonathanLiu, ShaochuangWang, HanStone, Eloise M.Chakraborty, SajibJayaraman, Padma-SheelaAmabilino, David B.Fromhold, MarkLong, Yi-TaoPérez García, M. Lluïsa (Maria Lluïsa)Turyanska, LyudmilaRahman, RumanRawson, Frankie J.NanotecnologiaElectroquímicaBioelectrònicaNanotechnologyElectrochemistryBioelectronics<p>Quantum biological tunnelling for electron transfer is involved in</p><p>controlling essential functions for life such as cellular respiration and</p><p>homoeostasis. Understanding and controlling the quantum effects in</p><p>biology has the potential to modulate biological functions. Here we merge</p><p>wireless nano-electrochemical tools with cancer cells for control over</p><p>electron transfer to trigger cancer cell death. Gold bipolar nanoelectrodes</p><p>functionalized with redox-active cytochrome c and a redox mediator</p><p>zinc porphyrin are developed as electric-field-stimulating bio-actuators,</p><p>termed bio-nanoantennae. We show that a remote electrical input regulates</p><p>electron transport between these redox molecules, which results in</p><p>quantum biological tunnelling for electron transfer to trigger apoptosis</p><p>in patient-derived cancer cells in a selective manner. Transcriptomics</p><p>data show that the electric-field-induced bio-nanoantenna targets the</p><p>cancer cells in a unique manner, representing electrically induced control</p><p>of molecular signalling. The work shows the potential of quantum-based</p><p>medical diagnostics and treatments.</p>Nature Publishing Group2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/208249Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a:Nature Nanotechnology, 2024, vol. 19, num.1, p. 106-114(c) Akhil Jain, et al., 2024http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2082492026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Wireless electrical–molecular quantum signalling for cancer cell apoptosis |
| title |
Wireless electrical–molecular quantum signalling for cancer cell apoptosis |
| spellingShingle |
Wireless electrical–molecular quantum signalling for cancer cell apoptosis Smith, Stuart Nanotecnologia Electroquímica Bioelectrònica Nanotechnology Electrochemistry Bioelectronics |
| title_short |
Wireless electrical–molecular quantum signalling for cancer cell apoptosis |
| title_full |
Wireless electrical–molecular quantum signalling for cancer cell apoptosis |
| title_fullStr |
Wireless electrical–molecular quantum signalling for cancer cell apoptosis |
| title_full_unstemmed |
Wireless electrical–molecular quantum signalling for cancer cell apoptosis |
| title_sort |
Wireless electrical–molecular quantum signalling for cancer cell apoptosis |
| dc.creator.none.fl_str_mv |
Smith, Stuart Jain, Akhil Gosling, Jonathan Liu, Shaochuang Wang, Han Stone, Eloise M. Chakraborty, Sajib Jayaraman, Padma-Sheela Amabilino, David B. Fromhold, Mark Long, Yi-Tao Pérez García, M. Lluïsa (Maria Lluïsa) Turyanska, Lyudmila Rahman, Ruman Rawson, Frankie J. |
| author |
Smith, Stuart |
| author_facet |
Smith, Stuart Jain, Akhil Gosling, Jonathan Liu, Shaochuang Wang, Han Stone, Eloise M. Chakraborty, Sajib Jayaraman, Padma-Sheela Amabilino, David B. Fromhold, Mark Long, Yi-Tao Pérez García, M. Lluïsa (Maria Lluïsa) Turyanska, Lyudmila Rahman, Ruman Rawson, Frankie J. |
| author_role |
author |
| author2 |
Jain, Akhil Gosling, Jonathan Liu, Shaochuang Wang, Han Stone, Eloise M. Chakraborty, Sajib Jayaraman, Padma-Sheela Amabilino, David B. Fromhold, Mark Long, Yi-Tao Pérez García, M. Lluïsa (Maria Lluïsa) Turyanska, Lyudmila Rahman, Ruman Rawson, Frankie J. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Nanotecnologia Electroquímica Bioelectrònica Nanotechnology Electrochemistry Bioelectronics |
| topic |
Nanotecnologia Electroquímica Bioelectrònica Nanotechnology Electrochemistry Bioelectronics |
| description |
<p>Quantum biological tunnelling for electron transfer is involved in</p><p>controlling essential functions for life such as cellular respiration and</p><p>homoeostasis. Understanding and controlling the quantum effects in</p><p>biology has the potential to modulate biological functions. Here we merge</p><p>wireless nano-electrochemical tools with cancer cells for control over</p><p>electron transfer to trigger cancer cell death. Gold bipolar nanoelectrodes</p><p>functionalized with redox-active cytochrome c and a redox mediator</p><p>zinc porphyrin are developed as electric-field-stimulating bio-actuators,</p><p>termed bio-nanoantennae. We show that a remote electrical input regulates</p><p>electron transport between these redox molecules, which results in</p><p>quantum biological tunnelling for electron transfer to trigger apoptosis</p><p>in patient-derived cancer cells in a selective manner. Transcriptomics</p><p>data show that the electric-field-induced bio-nanoantenna targets the</p><p>cancer cells in a unique manner, representing electrically induced control</p><p>of molecular signalling. The work shows the potential of quantum-based</p><p>medical diagnostics and treatments.</p> |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024 2024 2024 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/208249 |
| url |
https://hdl.handle.net/2445/208249 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: Nature Nanotechnology, 2024, vol. 19, num.1, p. 106-114 |
| dc.rights.none.fl_str_mv |
(c) Akhil Jain, et al., 2024 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) Akhil Jain, et al., 2024 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
9 p. application/pdf |
| dc.publisher.none.fl_str_mv |
Nature Publishing Group |
| publisher.none.fl_str_mv |
Nature Publishing Group |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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15.811543 |