Cell responses to electrical pulse stimulation for anticancer drug release
Electrical stimulation is an attractive approach to tune on-demand drug release in the body as it relies on simple setups and requires typically 1 V or less. Although many studies have been focused on the development of potential smart materials for electrically controlled drug release, as well as o...
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/171811 |
| Acceso en línea: | https://hdl.handle.net/2117/171811 https://dx.doi.org/10.3390/ma12162633 |
| Access Level: | acceso abierto |
| Palabra clave: | Conducting polymers Copolymers Medical electronics Nanoparticles Anticancer activity Cell damage Conducting polymer Drug delivery Electrostimulation Polycaprolactone Polyesters Polímers conductors Copolímers Electrònica mèdica Nanopartícules Àrees temàtiques de la UPC::Enginyeria química |
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Cell responses to electrical pulse stimulation for anticancer drug releasePuiggalí Jou, Anna|||0000-0002-2234-9436Valle Mendoza, Luis Javier del|||0000-0001-9916-1741Alemán Llansó, Carlos|||0000-0003-4462-6075Conducting polymersCopolymersMedical electronicsNanoparticlesAnticancer activityCell damageConducting polymerDrug deliveryElectrostimulationNanoparticlesPolycaprolactonePolyestersPolímers conductorsCopolímersElectrònica mèdicaNanopartículesÀrees temàtiques de la UPC::Enginyeria químicaElectrical stimulation is an attractive approach to tune on-demand drug release in the body as it relies on simple setups and requires typically 1 V or less. Although many studies have been focused on the development of potential smart materials for electrically controlled drug release, as well as on the exploration of different delivery mechanisms, progress in the field is slow because the response of cells exposed to external electrical stimulus is frequently omitted from such investigations. In this work, we monitor the behavior of prostate and breast cancer cells (PC-3 and MCF7, respectively) exposed to electroactive platforms loaded with curcumin, a hydrophobic anticancer drug. These consist in conducting polymer nanoparticles, which release drug molecules by altering their interactions with polymer, and electrospun polyester microfibres that contain electroactive nanoparticles able to alter the porosity of the matrix through an electro-mechanical actuation mechanism. The response of the cells against different operating conditions has been examined considering their viability, metabolism, spreading and shape. Results have allowed us to differentiate the damage induced in the cell by the electrical stimulation from other effects, as for example, the anticancer activity of curcumin and/or the presence of curcumin-loaded nanoparticles or fibres, demonstrating that these kinds of platforms can be effective when the dosage of the drug occurs under restricted conditionsPeer ReviewedMultidisciplinary Digital Publishing Institute (MDPI)20192019-08-0120192019-11-06journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/171811https://dx.doi.org/10.3390/ma12162633reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1718112026-05-27T15:37:01Z |
| dc.title.none.fl_str_mv |
Cell responses to electrical pulse stimulation for anticancer drug release |
| title |
Cell responses to electrical pulse stimulation for anticancer drug release |
| spellingShingle |
Cell responses to electrical pulse stimulation for anticancer drug release Puiggalí Jou, Anna|||0000-0002-2234-9436 Conducting polymers Copolymers Medical electronics Nanoparticles Anticancer activity Cell damage Conducting polymer Drug delivery Electrostimulation Nanoparticles Polycaprolactone Polyesters Polímers conductors Copolímers Electrònica mèdica Nanopartícules Àrees temàtiques de la UPC::Enginyeria química |
| title_short |
Cell responses to electrical pulse stimulation for anticancer drug release |
| title_full |
Cell responses to electrical pulse stimulation for anticancer drug release |
| title_fullStr |
Cell responses to electrical pulse stimulation for anticancer drug release |
| title_full_unstemmed |
Cell responses to electrical pulse stimulation for anticancer drug release |
| title_sort |
Cell responses to electrical pulse stimulation for anticancer drug release |
| dc.creator.none.fl_str_mv |
Puiggalí Jou, Anna|||0000-0002-2234-9436 Valle Mendoza, Luis Javier del|||0000-0001-9916-1741 Alemán Llansó, Carlos|||0000-0003-4462-6075 |
| author |
Puiggalí Jou, Anna|||0000-0002-2234-9436 |
| author_facet |
Puiggalí Jou, Anna|||0000-0002-2234-9436 Valle Mendoza, Luis Javier del|||0000-0001-9916-1741 Alemán Llansó, Carlos|||0000-0003-4462-6075 |
| author_role |
author |
| author2 |
Valle Mendoza, Luis Javier del|||0000-0001-9916-1741 Alemán Llansó, Carlos|||0000-0003-4462-6075 |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Conducting polymers Copolymers Medical electronics Nanoparticles Anticancer activity Cell damage Conducting polymer Drug delivery Electrostimulation Nanoparticles Polycaprolactone Polyesters Polímers conductors Copolímers Electrònica mèdica Nanopartícules Àrees temàtiques de la UPC::Enginyeria química |
| topic |
Conducting polymers Copolymers Medical electronics Nanoparticles Anticancer activity Cell damage Conducting polymer Drug delivery Electrostimulation Nanoparticles Polycaprolactone Polyesters Polímers conductors Copolímers Electrònica mèdica Nanopartícules Àrees temàtiques de la UPC::Enginyeria química |
| description |
Electrical stimulation is an attractive approach to tune on-demand drug release in the body as it relies on simple setups and requires typically 1 V or less. Although many studies have been focused on the development of potential smart materials for electrically controlled drug release, as well as on the exploration of different delivery mechanisms, progress in the field is slow because the response of cells exposed to external electrical stimulus is frequently omitted from such investigations. In this work, we monitor the behavior of prostate and breast cancer cells (PC-3 and MCF7, respectively) exposed to electroactive platforms loaded with curcumin, a hydrophobic anticancer drug. These consist in conducting polymer nanoparticles, which release drug molecules by altering their interactions with polymer, and electrospun polyester microfibres that contain electroactive nanoparticles able to alter the porosity of the matrix through an electro-mechanical actuation mechanism. The response of the cells against different operating conditions has been examined considering their viability, metabolism, spreading and shape. Results have allowed us to differentiate the damage induced in the cell by the electrical stimulation from other effects, as for example, the anticancer activity of curcumin and/or the presence of curcumin-loaded nanoparticles or fibres, demonstrating that these kinds of platforms can be effective when the dosage of the drug occurs under restricted conditions |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-08-01 2019 2019-11-06 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2117/171811 https://dx.doi.org/10.3390/ma12162633 |
| url |
https://hdl.handle.net/2117/171811 https://dx.doi.org/10.3390/ma12162633 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
| publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
| dc.source.none.fl_str_mv |
reponame:UPCommons. Portal del coneixement obert de la UPC instname:Universitat Politècnica de Catalunya (UPC) |
| instname_str |
Universitat Politècnica de Catalunya (UPC) |
| reponame_str |
UPCommons. Portal del coneixement obert de la UPC |
| collection |
UPCommons. Portal del coneixement obert de la UPC |
| repository.name.fl_str_mv |
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| repository.mail.fl_str_mv |
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1869411690625368064 |
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15.301603 |